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GEJALA KLINIS SEBAGAI PREDIKTOR PADA KARSINOMA SEL BASAL Pramuningtyas, Ratih; Mawardi, Prasetyadi
Biomedika Vol 4, No 1 (2012): Biomedika Februari 2012
Publisher : Universitas Muhamadiyah Surakarta

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Basal Cell Carcinoma (BCC) incidence is 75% of all skin cancers. BCC rarely causing mortality, but morbidity is high. Clinical diagnostic is the early detection of BCC suspicion, therefore, we required specific criteria that help to establish the clinical diagnosis. The objective of this study was to know the clinical sign as a predictor of basal cell carcinoma. Ten patients with skin tumors who came to dermatovenereological department of Dr. Moewardi hospital were included in this study. Clinical diagnosis using clinical criteria from keratinocyte carcinoma in A Cancer Journal For Clinicians in 2011 (Teleangiectasion, raise border, erythematous with bleeding, pigmentation, translucent appearance, and scarlike appearance) was used as reference of clinical diagnostic criteria. Histopathological examination was performed as a gold standard. All 10 subjects had histopathological finding consistent to BCC. The clinical examination like pigmentation were found in all subjects while teleangiectasia, raise border, erythema with bleeding were found on 9 subject. Translucent appearance was found on 6 subjects. While scarlike appearance was absent in all subjects. The criteria from keratinocyte carcinoma in A Cancer Journal For Clinicians in 2011 can be used to diagnosed BCC clinicallyKeywords : Basal cell carcinoma, Clinical Diagnostic Criteria

GEJALA KLINIS SEBAGAI PREDIKTOR PADA KARSINOMA SEL BASAL Pramuningtyas, Ratih; Mawardi, Prasetyadi
Biomedika Vol 4, No 1 (2012): Biomedika Februari 2012
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v4i1.261

Basal Cell Carcinoma (BCC) incidence is 75% of all skin cancers. BCC rarely causing mortality, but morbidity is high. Clinical diagnostic is the early detection of BCC suspicion, therefore, we required specific criteria that help to establish the clinical diagnosis. The objective of this study was to know the clinical sign as a predictor of basal cell carcinoma. Ten patients with skin tumors who came to dermatovenereological department of Dr. Moewardi hospital were included in this study. Clinical diagnosis using clinical criteria from keratinocyte carcinoma in A Cancer Journal For Clinicians in 2011 (Teleangiectasion, raise border, erythematous with bleeding, pigmentation, translucent appearance, and scarlike appearance) was used as reference of clinical diagnostic criteria. Histopathological examination was performed as a gold standard. All 10 subjects had histopathological finding consistent to BCC. The clinical examination like pigmentation were found in all subjects while teleangiectasia, raise border, erythema with bleeding were found on 9 subject. Translucent appearance was found on 6 subjects. While scarlike appearance was absent in all subjects. The criteria from keratinocyte carcinoma in A Cancer Journal For Clinicians in 2011 can be used to diagnosed BCC clinicallyKeywords : Basal cell carcinoma, Clinical Diagnostic Criteria

Dermal Filler Trisnarizki, Leonardo; Negara, Wisuda Putra; Mochtar, Moerbono; Julianto, Indah; Mawardi, Prasetyadi
Cermin Dunia Kedokteran Vol 46, No 9 (2019): Neuropati
Publisher : PT. Kalbe Farma Tbk.

Penggunaan filler untuk salah satu terapi rejuvenasi modern wajah banyak dilakukan di bidang dermatologi dan makin populer karena aman, efektif dan minimal invasif. Saat ini tersedia berbagai jenis filler yang bervariasi dalam durasi, kegunaan, potensi alergenik, keamanan dan cara aplikasi.The use of filler as one of the modern face rejuvenation therapies is widely performed in dermatology and become popular because it is safe, effective and minimally invasive. Various types of fillers are available, varying in duration, use, allergenic potential, safety and application mode.

Terapi Topikal Kombinasi Krim AsamTraneksamat 3%, Nikotinamid 3% Dan Microneedling Pada Pasien Melasma (Pilot Study) Tri Irfanti, Rakhma; Damayanti, Willa; Fatiharani Dewi, Putty; Oktriana, Putri; Mulianto, Nurrachmat; Mawardi, Prasetyadi
Cermin Dunia Kedokteran Vol 48, No 3 (2021): Obstetri dan Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Latar belakang : Melasma adalah hiperpigmentasi wajah pada wanita di area yang sering terpapar sinar matahari, bersifat kronis kambuhan. Saat ini formula Kligman masih menjadi pilihan terapi efektif tetapi mempunyai efek samping terutama pada pemakaian jangka lama. Kombinasi terapi asam traneksamat, nikotinamid dan microneedling merupakan terapi alternatif yang aman dan efektif untuk jangka lama. Tujuan : Untuk mengetahui keberhasilan terapi kombinasi topikal krim asam traneksamat 3%, nikotinamid 3% dan microneedling dalam menurunkan skor MASI dan indeks melanin pasien melasma. Kasus : Dua pasien perempuan umur 45 dan 44 tahun dengan keluhan utama bercak hitam di wajah. Pasien 1 dengan melasma tipe campuran dan pasien 2 dengan melasma tipe epidermal. Pasien diterapi topikal menggunakan krim kombinasi asam traneksamat 3% dan nikotinamid 3% dengan microneedling. Microneedling dilakukan pada minggu ke-0, ke-4 dan ke-8. Evaluasi terapi saat minggu ke-0, 4, 8 dan 12, dengan skor MASI dan indeks melanin menggunakan MexameterÂ®. Hasil : Terdapat penurunan nilai skor MASI dan indeks melanin. Simpulan : Terapi kombinasi krim asam traneksamat 3%, nikotinamid 3% dan microneedling dapat menurunkan skor MASI dan indeks melanin.Melasma is chronic and recurrent facial hyperpigmentation common in women and in areas frequently exposed to sunlight. Kligman formula therapy is still the effective treatment but has several side effects especially in long-term use. Combination of tranexamic acid, nicotinamide and microneedling is a safe and effective alternative for the long term therapy.Objective: To measure the effectiveness of topical combination therapy of 3% tranexamic acid cream, nicotinamide 3% and microneedling in reducing MASI score and melanin index in melasma patients. Cases: Two females aged 45 and 44 years with facial black spots. First patient diagnosed as mixed type melasma and 2nd patient with epidermal type melasma. Patients were treated with topical combination of 3% tranexamic acid and 3% nicotinamide cream with microneedling. Microneedling were done in the 0th, 4th and 8th weeks. Evaluation and measurement was done at weeks 0, 4, 8 and 12, with MASI scores and melanin index using MexameterÂ®. Results: There was a decrease in MASI score and melanin index.Conclusion: Combination therapy of tranexamic acid cream 3%, nicotinamide 3% and microneedling could reduce MASI score and melanin index.

The effect of face washing frequency on acne vulgaris patients Hastuti, Rini; Mustifah, Etty Farida; Ulya, Imroatul; Risman, Muhammad; Mawardi, Prasetyadi
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

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Background: Patients with acne often wash their faces twice a day, but there are not many studies supporting this practice. Methods: A single-blind randomized clinical trial was conducted in 38 subjects, divided into three groups based on face washing frequency (once, twice, and thrice a day). All groups used the same cleanser. The acne vulgaris severity and the number of lesions were assessed prior to study. After eight weeks, we re-assessed the acne severity, the number of lesions, the adverse event and patient’s self-evaluation. SPSS 17 was used to analyze the face washing frequency and the number of acne lesions. Results: Reduction in the average number of acne lesions was found in once and twice face washing groups, while the thrice group had increased number of acne lesions. The frequency of face washing with the number of lesions provided significant result in group 1, but it only reduced the number of comedones (p value = 0.041). Conclusion: Acne patients with only comedones lesions can be advised to wash their faces once a day.

Prevalence and risk factors of bacterial vaginosis among female sex workers in Surakarta Hastuti, Rini; Yuliarto, Danu; Triana, Agung; Damayanti, Willa; Irfanti, Rakhma Tri; Mardiana, Mardiana; Dewi, Putti Fatiharani; Aliwardani, Ambar; Abas, Ervianti; Sulistyo, Sulistyo; Mawardi, Prasetyadi; Ellistasari, Endra Yustin
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

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Background: Bacterial vaginosis (BV) is the most common vaginal infection in women of reproductive age and increases the risk of acquiring human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs). Data regarding the association between sexual activity and BV acquisition is contradictory. Thus, tracking the prevalence and associated risk factors of BV among female sex workers (FSWs) is necessary to improve our understanding and control of STDs and the HIV epidemic. Methods: The subjects of this study were FSWs in Surakarta. This study adopted a cross-sectional design, and diagnosis was established using Amsel criteria. Interviews were conducted using questionnaires to collect data of risk factors, including demographic factors (age, education level, daily income, marital status, location of sex), sociologic factors (age of first intercourse; age of first FSW encounter; duration of work as an FSW; number of clients/day; condom, contraceptive, and vaginal douching use; violence experienced as an FSW; smoking habits; alcohol consumption; and drug use), and knowledge factors (knowledge of STDs and HIV). Statistical analysis was performed by using bivariate analysis. Results: We interviewed 175 FSWs with an average age of 40.66 years. BV was detected in 28 subjects (16%). Risk factors associated with BV include alcohol (p = 0.022) and drug use (p = 0.022). Conclusion: Other than routine screening for STDs and HIV, FSWs should be encouraged to participate in prevention programs aiming to regulate alcohol and drug use to decrease the incidence of BV infection.

Prognostic Factor of H-Zone Area in Basal Cell Carcinoma Mawardi, Prasetyadi; Prihadi, Irfany Arafiasetyanto; Irawanto, Muhammad Eko
Budapest International Research and Critics Institute-Journal (BIRCI-Journal) Vol 4, No 4 (2021): Budapest International Research and Critics Institute November
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v4i4.3210

The study data were taken from secondary data obtained from medical records of BCC patients in Dr. Moewardi Hospital. The data were categorized based on gender, age, occupation, predilection/ location of tumor based on Baxter criteria, which divided the area into H-zone dan non-H-zone. H-zone was described to cover temporal, auricular, orbital, nasal, upper mandibular. Whereas the tumor size was divided into two, less than 2 cm and more than 2 cm. H-zone is a predilection with a high risk toward tumor biological characteristics, such as recurrence risk, aggressivity risk, and tumor infiltrative. The study obtained an ethics clearance from Health Research Ethics Committee of Dr. Moewardi Hospital with number 762/VIII/HREC/2021. The analysis was conducted to test whether there was a correlation or effect between two variables or more. In the study, the researcher also conducted statistics test to measure the correlation intensity of two variables or more by using Chi-square (X2), statistics test was conducted by using SPSS 22 for Windows. 99 patients were obtained from the medical records however only 70 patients who met the study requirements, who were subsequently categorized based on gender, age, occupation, BCC location and size, disease duration. 29 patients were excluded due to incomplete medical records (BCC location, BCC size, and treatment history were not found) non-primary BCC, data duplication, patients with more than one medical records, the result of histopathological test did not indicate seborrheic keratosis and Squamosa Cell Carcinoma. Based on the study there were more female patients compared to male patients. it discovered 45 female patients and 25 male patients (64,3% compared to 35,7%), with the age range was from 22-90 years, the BCC tumor was endured for more than 2 years, based on the education most of the patients had primary education background (elementary school and junior high school), the majority occupation of the patients was farmer (30%), followed by housewife (28,57%).

Cutaneus T-Cell Lymphoma in 53 Years Old Woman: Histopathological Features Ivani, Ivani; Murasmita, Alamanda; Mawardi, Prasetyadi; Oktavriana, Triasari
Journal La Medihealtico Vol. 5 No. 4 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i4.1495

Cutaneous T-cell lymphomas (CTCLs) are clinically heterogeneous T-cell lymphomas that arise in the skin and are characterized by their clinical and pathological features. The pathogenesis of CTCL is not fully understood. The incidence of CTCL increases significantly with age, with a median age at diagnosis at about 55 years of age and a four-fold increase in incidence appreciated in patients over 70. A 53 year old woman presented with complaints of reddish spots and lumps on her left forearm and back which spread to her chest, stomach and legs. On examination, a lump the size of a golf ball was found on the left forearm and back as well as reddish spots that felt itchy and painful. Histopathological examination with HE staining showed proliferation of lymphoid follicles without a germinal center and monotonous cells of small to medium size partially surrounding the tubular glands in the dermis layer. Immunohistochemical examination revealed positive for CD 45 as well as CD 3 and negative for CD 20. A case of CTCL has been reported in a 53-year-old woman. Histopathological examination and immunohistochemistry are important to diagnose this disease.

Koinsidensi Vaginosis Bakterial pada Pasien dengan Kandidiasis Vulvovaginalis Kronis Pradestine, Sesia; Mawardi, Prasetyadi
Health and Medical Journal Vol 6, No 3 (2024): HEME September 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i3.1620

Vaginosis bakterial (VB) dan kandidiasis vulvovaginal (KVV) adalah infeksi vagina yang umum terjadi dengan etiologi yang berbeda, namun dapat terjadi bersamaan dan mempersulit pengobatan. Ketidakseimbangan dalam mikrobiota vagina menjadi ciri khas VB, sedangkan KVV adalah infeksi jamur yang disebabkan oleh Candida spp. Interaksi antara infeksi ini dapat mempengaruhi hasil pengobatan. Kami melaporkan seorang wanita berusia 19 tahun yang datang dengan keputihan berwarna putih kental, berbau, dan gatal. Dia memiliki riwayat gejala yang berulang dan sering menggunakan antibiotik. Pemeriksaan fisik menunjukkan beberapa papula dan cairan putih susu. Pemeriksaan mikroskopis menunjukkan adanya pseudohifa, sel tunas, dan bakteri batang gram negatif dengan sel petunjuk. Pasien didiagnosis dengan VB bersamaan dengan KVV kronis dan diobati dengan metronidazol dan flukonazol, diikuti dengan itrakonazol, yang menghasilkan perbaikan. Terjadinya VB dan KVV secara bersamaan mempersulit pengobatan karena mikrobiota vagina yang berubah. Antibiotik untuk VB dapat meningkatkan pertumbuhan Candida, yang menyebabkan KVV. KVV kronis pada pasien membutuhkan terapi antijamur yang lebih lama. Memahami interaksi antara VB dan KVV sangat penting untuk manajemen yang efektif, terutama pada kasus-kasus kronis. Kesimpulannya adalah manajemen VB dan KVV yang efektif secara bersamaan membutuhkan pemahaman yang komprehensif tentang interaksi keduanya dan strategi pengobatan yang disesuaikan. Penelitian lebih lanjut diperlukan untuk mengeksplorasi mekanisme interaksi ini dan meningkatkan pendekatan terapeutik.

Correlation of CD4+ levels and caspase-3 in condyloma acuminata with HIV reactive patients Nurfaiqoh, Elok; Mawardi, Prasetyadi; Dharmawan, Nugrohoaji; Julianto, Indah; Ellistasari, Endra Yustin
MEDISAINS Vol 22, No 1 (2024)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v22i1.21501

Background: Human papillomavirus is an infection that causes malignancy because of persistency and modulation of apoptotic pathways, especially caspase-3. Factors that can increase persistency, recurrency, and malignancy of HPV infection include HIV infection with low CD4 levels. There is disagreement or deep molecular understanding of the induction and modulation of apoptosis in HIV-mediated CD4+ T cell depletion, especially in CA. However, it is necessary to see how CD4+ levels can influence caspase-3, so it may open up new avenues for supporting investigation to consider the presence of malignancy or therapeutic strategies regarding CD4+ can induce apoptosis.Purpose: This study aimed to determine whether there is a correlation between CD4+ levels and caspase-3 expression in condyloma acuminata with HIV reactive patients.Methods: This is an analytic observational study with a cross-sectional design. The research was conducted at Dr. Moewardi General Hospital from August to December 2023. Nineteen patients with condyloma acuminata and HIV reactive were included in this study with a consecutive sampling technique. The expression of caspase-3 was assessed using immunohistochemical staining, looking at the percentage of stained cell nuclei and cytoplasm and CD4+ levels with flow cytometry examination—data analysis using Pearson correlation.Results: Respondents in this study were primarily men, self-employed with heterosexual orientation and genito-genital-oral sexual intercourse. The statistical analysis showed no significant relationship (p: 0.300, r: -0.251) between CD4+ levels and caspase-3 expression.Conclusions: While not statistically significant, CD4+ level is reduced in correlation with increased caspase-3 expressions.

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