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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia
Daniek Viviandhari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Other

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Aktivitas Achyranthes Aspera Linn. dalam Menurunkan Kadar Kolesterol dan Glukosa Darah Hewan Uji Resistensi Insulin Daniek Viviandhari; Maharadingga Maharadingga; Farah Zahria; Putri Hardiyanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.964

Abstract

The most common causative factor in patients with type 2 diabetes is insulin resistance. Achyranthes Aspera Linn. is known as a medicinal plant which has been shown based on previous research to reduce total cholesterol, triglyceride, and blood glucose levels, but the effective dose is not yet known in insulin resistance rats. Further study is necessary to ensure the effect and also the dose. The purpose of the research was to determine the activity of the extract in reducing levels of total cholesterol, triglycerides, blood glucose, and OGTT in insulin resistance rats. 7 groups (each group consist of 4 animals) were divided, i.e. normal control (not induced), negative group (given with Na-CMC 0.5%), positive group 1 (fenofibrate), positive group 2 (metformin HCl), extract group dose 250, 500, and 750 mg / kg BW for 14 days of treatment. Induction of insulin resistance using streptozotocin. Total cholesterol, triglyceride, blood glucose, and OGTT levels were measured using a clinical spectrophotometer. Oneway ANOVA followed by the Tukey test were used to analyze the data. Data indicated that the third dose extract (750 mg/kg BW) could lower total cholesterol, triglycerides, blood glucose, and OGTT with the percentages of reduction of 48.83%, 48.95%, and 61.31%, respectively, and at OGTT the smallest AUC value was 23,991 mg/dL per minute.
Efek Antifertilitas dari Ekstrak Daun Pepaya (Carica papaya L.) pada Tikus Putih Jantan Galur Sprague Dawley Ema Dewanti; Daniek Viviandhari; Nitia Lonica; Safitri Mutia Isnarningtyas
Jurnal Jamu Indonesia Vol. 5 No. 1 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1095.144 KB) | DOI: 10.29244/jji.v5i1.182

Abstract

Daun pepaya mengandung senyawa alkaloid, flavonoid, saponin, dan tanin yang diduga memiliki efek antifertilitas. Tujuan penelitian ini adalah untuk mengetahui efek antifertilitas dari ekstrak daun pepaya dengan parameter kualitas sperma serta bobot testis dan vesikula seminalis pada tikus putih jantan galur Sprague Dawley. Penelitian ini dibagi menjadi 2 tahap yaitu ekstraksi dan uji antifertilitas. Ekstraksi dilakukan dengan metoda maserasi bertingkat menggunakan pelarut etanol, etil asetat dan n-heksana. Perlakuan uji antifertilitas terbagi menjadi delapan kelompok yaitu 2 kelompok kontrol dan 6 kelompok perlakuan (ekstrak etanol 100 dan 150 mg/kg BB, ekstrak etil asetat 100 dan 150 mg/kg BB, ekstrak n-heksana 100 dan 150 mg/kg BB). Ekstrak daun pepaya diberikan secara oral selama 20 hari. Pada hari ke-21 tikus dibedah dan dianalisa kualitas spermatozoa serta diukur bobot testis dan vesikula seminalis. Data yang didapat diuji secara statistik dengan ANOVA satu arah dan dilanjutkan dengan uji Tukey HSD. Hasil penelitian menunjukkan ekstrak n-heksana, ekstrak etil asetat dan ekstrak etanol 70% daun pepaya dapat menurunkan jumlah dan viabilitas spermatozoa serta menurunkan bobot testis dan vesikula seminalis. Ekstrak yang paling baik dalam mempengaruhi efek antifertilitas adalah ekstrak etanol 70% dosis 150 mg/kgBB.
Co-Authors Ema Dewanti Farah Zahria Maharadingga Maharadingga Nitia Lonica Putri Hardiyanti Safitri Mutia Isnarningtyas