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All Journal MNJ (Malang Neurology Journal) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Dyson, Nathaniel Gilbert
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Health Professions Medicine & Pharmacology Neuroscience Public Health

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THE ASSOCIATION OF SOCIODEMOGRAPHIC FACTORS WITH MOTOR SYMPTOMS IN PATIENTS WITH PARKINSONISM Dyson, Nathaniel Gilbert; Tiksnadi, Amanda
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.20

Abstract

Background: Motor symptoms in patients with parkinsonism severely impair daily activities. Sociodemographic factors are known to play an important role in various chronic diseases, but their relationship with parkinsonism has not been studied yet. Objective: This study aims to determine the association between sociodemographic factors and motor symptoms among patients with parkinsonism. Methods: This cross-sectional study was conducted at Dr. Cipto Mangunkusumo National Hospital Jakarta by using the MDS Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II questionnaire about daily motor symptoms. The target sample in this study were patients with parkinsonism based on a doctor's diagnosis, fluent in Indonesian, and had internet access. Results: A total of 50 respondents were recruited with the most motor symptoms being difficulty dressing (90%), followed by writing, doing hobbies, tremors, and balance (88%). Bivariate analysis found that patients with low education, low income, and married had significantly worse motor symptoms (p<0.05). Multivariate analysis revealed that low education level and married status were significant risk factors, while high income level was a protective factor against poor motor symptoms. Conclusion: Sociodemographic factors were significantly associated with motor symptoms in parkinsonism patients. This study recommends personalized patient management based on the patient's sociodemographic factors.
EFIKASI TERAPI PERILAKU KOGNITIF BERBASIS DARING TERHADAP GEJALA DEPRESI DAN ANSIETAS PADA PASIEN PARKINSON: SEBUAH KAJIAN LITERATUR Dyson, Nathaniel Gilbert
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.526

Abstract

Background: Parkinson’s Disease (PD) is a chronic neurodegenerative disease with neuropsychiatric symptoms such as depression and anxiety, which are often overlooked or untreated. Psychiatric treatment which is tailored especially for PD patients is still limited. Objectives: To determine the efficacy of internet-based cognitive behavioral therapy (ICBT) in treating depression and anxiety in PD patients. Methods: Literature searching is done in online databases PubMed, Cochrane, SCOPUS, ScienceDirect, and EBSCOHost. Results: Significant improvement of depression and anxiety score in patients treated with ICBT. ICBT also has a higher adherence and completion rate because of its flexibility and convenience. Factors affecting ICBT include duration of disease, patients’ perception, and patient-clinician relationship. Conclusion: ICBT is an effective alternative therapy to treat neuropsychiatric symptoms in PD patients, especially depression and anxiety. Overall, studies show improvement of depression and anxiety measured with standardized questionnaires, and patients show good adherence and high completion rate with this therapy. Keywords: Internet-based cognitive behavioral therapy, neuropsychiatric symptoms, Parkinson’s Disease
POTENTIAL UTILIZATION OF SOLID LIPID NANOPARTICLES AS A SOLUTION TO OPTIMIZE THE BIOAVAILABILITY OF ANTIDEPRESSANT DRUG SSRI IN IMPROVING THE EFFECTIVENESS OF DEPRESSION TREATMENT: A LITERATURE REVIEW Dyson, Nathaniel Gilbert
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 2 (2024): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 2 Periode O
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i2.556

Abstract

Background: Currently, more than 264 million people globally suffer from major depressive disorder. Pharmacological treatments that are the main choice in cases of depression such as antidepressants are still constrained by low bioavailability, especially in the brain. Recent research shows the potential of solid lipid nanoparticles (SLN) as a specific antidepressant drug carrier agent and is able to increase bioavailability in the brain. Methods: This literature review was compiled based on article searches in international databases, such as PubMed, Scopus, and Cochrane for the last 10 years until November 11, 2022. Study inclusion criteria included clinical and in vitro studies that measured differences in bioavailability of antidepressant drugs with and without SLN. Discussion: In the research that has been conducted to date, it is known that SLN can carry duloxetine through the blood brain barrier effectively. This is evidenced by the behavioral despair test and BDNF concentrations that show a significant cure for depression and can match normal or control rats. In addition, in the biosafety test, SLN has also been shown to be safe for use in in vitro and in vivo experiments, namely through dermal administration mainly, and oral and parenteral, although it still requires further study. Conclusion: In conclusion, SLN is a very potential solution to optimize the bioavailability of SSRI antidepressant drugs. Further clinical research is needed to confirm the efficacy and safety of using SLN as a carrier for antidepressant drugs in humans, especially in oral and parenteral administration due to the lack of data to date.
Co-Authors Tiksnadi, Amanda