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All Journal Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Dwi Saryanti
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Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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FOTOPROTEKSI DAN AKTIVITAS ANTIOKSIDAN NANOENKAPSULASI EKSTRAK ETANOL BUAH KERSEN (Muntingia calabura L.) Kusumawardany, Sony Febri; Nastiti Utami; Dwi Saryanti
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.24892

Abstract

Senyawa aktif dalam buah kersen memiliki potensi sebagai antioksidan dan dapat berfungsi sebagai fotoprotektif diantaranya flavonoid dan senyawa fenolik lainnya. Kelemahan senyawa dari bahan alam bersifat termolabil, sehingga memerlukan modifikasi enkapsulasi untuk memperoleh potensi yang maksimal.  Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan efek fotoproteksi nanoenkapsulasi ekstrak etanol buah kersen (Muntingia calabura L.) dengan variasi konsentrasi kitosan. Ekstraksi simplisia menggunakan metode maserasi dengan etanol 96% dan formulasi nanoenkapsulasi menggunakan metode gelasi ionik dengan kitosan 0,1%; 0,15%; dan 0,2%. Pengujian yang dilakukan yaitu skrining fitokimia, uji ukuran partikel dengan Particle Size Analysis (PSA), analisis gugus dengan FTIR, aktivitas antioksidan dengan metode DPPH, dan penentuan nilai Sun Protection Factor (SPF). Hasil yang didapatkan pada uji ukuran partikel dari ketiga formula masuk dalam rentang ukuran nanoenkapsulasi 1-1000 nm dan ukuran yang paling baik pada Formula II yaitu 152,8±9,5 nm. Hasil analisis gugus fungsi nanoenkapsulasi ekstrak etanol buah kersen menunjukkan serapan milik kitosan dan ekstrak dengan memuculkan dua serapan dominan pada bilangan gelombang 1629,79 cm-1 yang menunjukkan adanya gugus bending N-H dan 3261,42 cm-1 yang menunjukkan adanya serapan gugus hidroksil yang tumpang tindih dengan vibrasi streching N-H. Aktivitas antioksidan yang dilihat dari IC50 dari ketiga formula nanoenkapsulasi ekstrak etanol buah kersen termasuk kategori sangat kuat yaitu Formula I (9,57±0,02 mg/L), Formula II (9,45±0,01 mg/L), dan Formula III (9,05±0,04 mg/L). Nilai SPF yang diperoleh oleh Formula I, II, III secara berturut-turut yaitu 12,1828±0,0045; 14,3430±0,0008; dan 14,7285±0,0091.
OPTIMASI CAMPURAN PATI JAGUNG DAN AVICEL PH 101 SEBAGAI BAHAN PENGHANCUR PADA TABLET EKSTRAK BUAH PARE (Momordica charantia L.) SECARA GRANULASI BASAH Dwi Saryanti; Heny Ismawati; Iwan Setiawan
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i1.239

Abstract

Bitter melon fruit (Momordica charantia L.) can be used as traditionally to reduce blood sugar levels. Avicel PH 101 and corn starch are efficacious as fillers, disintegration excipient and binders. The combination of Avicel PH 101 with corn starch is expected to be able accelerate the tablet disintegration time of tablet. This research was aimed to get the optimum formula tablets of bitter melon extract tablets using combination of corn starch and avicel PH 101. Bitter melon extract was formulated in tablet with wet granulation method. Bitter melon extract was obtained by maceration with ethanol 70% as solvent. Tablet formula based on the Simplex Lattice Desaign method uses Design Expert software version 11 with parameters that are used weight uniformity, hardness, friability and disintegration time. The results obtained from the simplex lattice design compared with the results of testing using the SPSS 18 program using the One Sample T-Test with a confidence level of 95%. The result of this research indicate bitter melon extract was made by tablets with wet granulation method with a combination of Avicel PH 101and corn starch, a formula with a ratio of 51% : 49% selected as the optimum formula with weight uniformity, hardness, friability and disintegration time meeting the requirements. Keywords : bitter melon extract, tablets, corn starch, avicel PH 101, simplex lattice design
OPTIMASI KARBOPOL DAN HPMC DALAM FORMULASI GEL ANTIJERAWAT NANOPARTIKEL EKSTRAK DAUN SIRIH (Piper betle Linn) Dwi Saryanti; Dian Nugraheni; Nisa Sindi Astuti; Natasya Intania Pertiwi
Jurnal Ilmiah Manuntung Vol 5 No 2 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v5i2.293

Abstract

Gel is a semisolid preparation that is clear, translucent containing active ingredients, can provide a cool effect on the skin and good spread of the skin. The use of gelling agent in gel formulations greatly affects the physical properties of the resulting gel preparations. HPMC is a gel forming material that is neutral and can form a clear gel and can maintain the viscosity of the resulting gel, while carbopol are easily dispersed in water and produce preparations with sufficient viscosity. The research conducted aims to determine the comparison of carbopol and HPMC in the optimal gel formula of betel leaf extract nanoparticles with Simplex Lattice Design method. The response used was pH, viscosity, spreadability, adhesion and antibacterial activity against Staphylococcus aureus. The results obtained by carbopol concentration of 80.9% and HPMC 19.1% was the optimal gel formula of betel leaf extract nanoparticle. Based on the verification, an insignificant difference was obtained between the predictions of the software and the results of the tests performed. This shows that the method used was valid or can be trusted.
OPTIMASI PENGGUNAAN KARBOPOL DAN Na CMC PADA FORMULA GEL EKSTRAK ETANOL DAUN KAYU PUTIH (Melaleuca leucadendra L.)DENGAN METODE SIMPLEX LATTICE DESIGN Arum Kavita Sari; Dwi Saryanti
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.458

Abstract

Eucalyptus leaves (Melaleuca leucadendra L.) are a type of plant that has antibacterial properties for Klebsiella pneumoniae, which is a bacteria that causes respiratory tract infections (ISPA). Eucalyptus leaves have active compounds thought to have Klebsiella pneumoniae antibacterial activity, namely flavonoids and phenolic, in the ethanol extract of eucalyptus leaves with a concentration of 20%. The gel preparations have the advantage of being easy to dry out, forming a film layer that is easy to wash and gives a cool feeling to the skin. This study aims to make an optimal eucalyptus leaf ethanol extract gel formula with variations of carbopol and Na-CMC optimally using the Simplex Lattice Design (SLD) method. Eucalyptus leaf extraction used the maceration method with 70% ethanol solvent. Determination of the optimal formula using the Simplex Lattice Design (SLD) method using Design Expert 10 software with test parameters for pH, viscosity, adhesion and dispersion power. Verification of the optimal formula used the One sample t-test, and the stability test was carried out using the freeze-thaw method. This study provides optimal formula results with a ratio of 38% carbopol gel base and 62% Na-CMC. The results of the verification test show that the prediction results with the test results are not significantly different, indicated by a p value> 0.05, this shows that the formula for the results of the Simplex Lattice Design (SLD) method is valid as expected including organoleptic, homogeneity, pH, viscosity, adhesion, and power. spread.
OPTIMASI GEL EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi Linn) SEBAGAI ANTIBAKTERI Staphylococcus aureus Dwi Saryanti; Iwan Setiawan; Pingki Retnosari
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.666

Abstract

Belimbing wuluh leaves (DBW) are a plant that has antibacterial properties with active flavonoid compounds. The leaf extract with a concentration of 10% has a strong inhibitory ability against Staphylococcus aureus (SA) bacteria. Gel preparations have several advantages, including having water content with cooling, soothing, moisturizing properties, easy to use, easy to penetrate the skin, and provide a healing effect. The aim of this research was to determine the optimal comparison of CMC-Na and Carbopol 940 bases in starfruit leaf extract gel preparations using the Simplex lattice design (SLD) method and to evaluate the antibacterial activity on SA bacteria. DBW extraction uses a maceration extraction method using 96% ethanol. The optimal DBW extract gel formula was determined using the Simplex Lattice Design (SLD) method using Design Expert 11. Verification of the optimal DBW extract gel formula using one sample T-test. The antibacterial test on SA used the well method and the results were analyzed using One Way Anova. The optimal formula obtained was tested for stability using freeze thaw cycling and acceptability tested. The optimal concentration of CMC-Na and Carbopol 940 produced by the SLD method is CMC-Na of 35% (0.7 g) and Carbopol 940 of 65% (1.3 g) with a total base weight of 2g. The results of the antibacterial test showed that the gel preparation could inhibit SA bacteria with an inhibition zone of 14.43 ± 0.707 mm. The results of the optimal formula verification test obtained a p value of >0.05, so the data obtained was not significantly different and it can be said that the formula for the SLD method results was valid including pH, viscosity, spreadability, adhesion power. The optimal gel formula obtained shows that the preparation is stable in storage and can be accepted by respondents.
Co-Authors Arum Kavita Sari Dian Nugraheni Heny Ismawati Iwan Setiawan Iwan Setiawan Kusumawardany, Sony Febri Nastiti Utami Natasya Intania Pertiwi Nisa Sindi Astuti Pingki Retnosari