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All Journal Martabe : Jurnal Pengabdian Kepada Masyarakat Food Science and Technology Journal (Foodscitech) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Kesehatan Tambusai Jurnal EduHealth Borneo Journal of Pharmacy
Rafikayanti, Agustin
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Agriculture, Biological Sciences & Forestry Arts Humanities Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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THE ANTIOXIDANT ACTIVITY COMPARISON OF MANALAGI APPLE FRUIT (Malus Sylvestris Mill) AND ITS PROCESSED PRODUCTS IN BATU CITY WITH ABTS METHOD Astuti, Engrid Juni; Rafikayanti, Agustin; Purwanto, Septiana Tita; Puspitasari, Chenchen; Rika, Wenni Fista; Yesica, Yeni
Food Science and Technology Journal (Foodscitech) Vol. 4 No. 2 (2022): FOODSCITECH
Publisher : Universitas Dr Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25139/fst.v4i2.4143

Abstract

Chemical compounds that can donor one or more electrons to free radicals to inhibit free radical reactions are called antioxidants. Manalagi apple is a fruit with high antioxidant activity. Manalagi apple is a typical fruit of Batu City. Processed apple products are apple cider, vinegar, dodol, and chips. These products are sold in Batu city and produced the same home industry. The aim of this study was to determine the antioxidant activity comparison between Manalagi apple and four processed apple products based on IC50 values. This study used the ABTS method (2,2-azino bis (3-ethyl benzothiazoline-6-sulfonic acid) and analysis used spectrophotometric visible. IC50 value as apples and their processed products were analyzed using a one-way ANOVA. The study results indicated that IC50 value of Manalagi apple was insignificantly different from the processed apple product of dodol and chips. However, the IC50 value of manalagi apple was significantly different from apple cider and vinegar.
PEMANFAATAN SENYAWA METABOLIT SEKUNDER KAWISTA (Limonia acidissima) UNTUK PENGELOLAAN DIABETES: TINJAUAN ANALISIS JEJARING FARMAKOLOGI Hentu, Dina Siti Rahma M.; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6964

Abstract

This study aims to explore the potential of secondary metabolite compounds from the kawista plant (Limonia acidissima) as antidiabetic agents through an in silico approach. We utilized pharmacological network analysis and analysis of the most important proteins to identify potential protein targets and signaling pathways involved in diabetes regulation. The analysis revealed that secondary metabolite compounds from kawista have the potential to affect various crucial aspects of glucose and lipid metabolism in the body, including through interactions with key proteins such as AKT1. These findings provide new insights into the development of additional therapies for diabetes treatment, and demonstrate the potential of in silico methods in accelerating the discovery and development of new drugs.
Potential Activity Of Secondary Metabolites Of Kawista (Limonia Acidissima) As Neurodegenerative Diseases : A Network Pharmacology Approaches Dina Siti Rahma M. Hentu; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kawista (Limonia acidissima) is a tropical plant traditionally used in South and Southeast Asian medicine, and its known for its rich nutritional profile and bioactive compounds. This study explores the therapeutic potential of kawista for neurodegenerative diseases. This study aims to investigate the potential of kawista in managing neurodegenerative through a pharmacological network approach. Proteins that can interact with secondary metabolites of kawista were predicted using SwissTargetPrediction, proteins related to neurodegenerative were obtained from GeneCards. The intersecting results were analyzed using STRING with GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment methods. From 47 secondary metabolites of kawista, 218 neuro-related proteins was identified potentially interacting with kawista's secondary metabolites. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and disease-gene association analyses highlighted key biological processes, molecular functions, cellular components, and pathways relevant to neurodegenerative disease mechanisms. The findings suggest that kawista's bioactive compounds could modulate critical pathways and receptor activities, offering insights into developing novel, effective therapies for neurodegenerative disorders. This research providing a scientific basis for kawista-based therapeutic strategies aimed at improving neurodegenerative disease outcomes.
POTENSI KAWISTA (LIMONIA ACIDISSIMA) DALAM PENGELOLAAN HIPERTENSI : ANALISIS JEJARING FARMAKOLOGI Pertiwi, Cinta Junaidi Putri; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Jurnal Kesehatan Tambusai Vol. 5 No. 2 (2024): JUNI 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i2.28226

Abstract

Hipertensi adalah kondisi kronis yang dapat menyebabkan komplikasi kardiovaskular serius, dan kawista (L. acidissima) telah digunakan dalam pengobatan tradisional untuk berbagai penyakit, termasuk hipertensi. Namun mekanisme molekuler L. acidissima dalam mengatur tekanan darah belum sepenuhnya dipahami. Penelitian ini bertujuan untuk menyelidiki potensi kawista L. acidissima dalam pengelolaan hipertensi melalui pendekatan jejaring farmakologi. Senyawa metabolit sekunder L. acidissima diambil dari literatur, protein yang dapat berinteraksi dengan metabolit sekunder diprediksi dengan menggunakan SwissTargetPrediction, protein yang berhubungan dengan hipertensi diperoleh dari GeneCards. Hasil irisan protein dari SwissTargetPrediction dan GeneCards dianalisis lebih lanjut menggunakan STRING dengan metode GO (Gene Ontology) dan KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment. Protein yang paling memiliki peranan dalam hipertensi dianalisis dengan menggunakan algoritma MCC (Maximal Clique Centralit) dari CytoHubba. Analisis GO enrichment menunjukkan keterlibatan protein-protein dalam regulasi tekanan darah sistemik dan respons biologis lainnya yang relevan dengan hipertensi. Analisis KEGG enrichment mengungkap keterlibatan jalur-jalur sinyal utama seperti cGMP-PKG dan HIF-1, serta jalur regulasi hormonal penting dalam regulasi tekanan darah. Analisis MCC top 10 dari CytoHubba menyoroti peran sentral gen-gen seperti ACE, NOS3, dan EDNRA dalam jaringan biologis, menunjukkan potensi mereka sebagai target terapeutik dalam pengelolaan hipertensi. Senyawa metabolit sekunder L. acidissima memiliki potensi digunakan sebagai terapi untuk hipertensi.
Integrative Network Pharmacology Unveils Limonia acidissima as a Potential Natural Product for Targeting Cancer Wahyuni, Reni Sri; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6988

Abstract

Cancer remains a formidable health challenge worldwide, with complex molecular mechanisms driving its initiation, progression, and therapeutic resistance. In this study, we employed bioinformatics analyses to elucidate the molecular underpinnings of cancer biology, focusing on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Our GO analysis revealed the enrichment of key biological processes such as protein phosphorylation, regulation of programmed cell death, and transmembrane receptor signaling pathways, underscoring the critical roles of signaling cascades and regulatory mechanisms in tumorigenesis. Similarly, molecular functions such as protein kinase activity and ATP binding were identified as significantly enriched, highlighting the importance of protein kinases and molecular interactions in cancer development and progression. The KEGG pathway analysis further delineated dysregulated signaling pathways associated with cancer, including the MAPK and PI3K-Akt signaling pathways, implicating these pathways as central regulators of cancer progression. These findings deepen our understanding of cancer biology and offer potential targets for therapeutic intervention. Integrating multi-omics data and systems biology approaches may provide deeper insights into the intricate networks underlying cancer pathogenesis, paving the way for developing more effective treatments for cancer patients.
IbM PEMBUATAN SABUN CUCI TANGAN UNTUK MENCEGAH PENULARAN VIRUS COVID 19 PADA MASA PANDEMI Juni Astuti, Engrid; Rafikayanti, Agustin; Muchlisin, M. Artabah; Rohmaturrizqi, Arvil; Bilgis Nurfatiyah, Rize; Huda Prastyo, Miftahul; Ikka Choirun Nisa, Vasda
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 7 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i7.2562-2569

Abstract

IbM kali ini menggunakan mitra siswa sekolah menengah SMP Muhammadiyah 4 Singosari. Sekolah menengah ini berada di jalur protokol Singosari dan lokasi yang sangat strategis karena berada didekat pusat kecamatan Singosari. SMP ini terdiri dari kelas I sampai dengan kelas III dengan jumlah siswa total sekitar 150 siswa yang terbagi menjadi 6 kelas belajar. Disini pengabdi akan melakukan pelatihan terhadap siswa sekolah kelas 2 untuk membuat sabun cuci tangan yang bisa digunakan untuk mencegah penularan virus COVID-19 pada saat pandemi. Jumlah siswa kelas 2 yang mengikuti kegiatan berjumlah sekitar 25 orang siswa beserta guru pendamping kelas. Saat ini seperti yang kita ketahui pada masa pandemi bahwa penyebaran virus COVID-19 sangat tinggi dan fluktuatif. Hingga tahun 2022 pulau jawa masih mengharuskan pembatasan aktifitas sosial di masyarakat, serta untuk kegiatan pembelajaran sampai tahun 2022 masih dibatasi dengan media Daring. Pencegahan Covid pada masa itu masih disarankan menggunakan masker, sering mencuci tangan dan menjaga jarak. Untuk mencuci tangan seperti yang kita ketahui selain handsanitizer yang digunakan dalam keadaan darurat maka harus digunakan sabun cuci tangan. Dalam proses pendampingan siswa akan dilakukan awal dengan pemberian pretest tentang dasar pembuatan sabun dan teori kimia yang mendasari proses penyabunan. Kemudian akan dilakukan pemberian materi berupa teknik bagaimana cara pembuatan sabun beserta teori yang mendasari teknik penyabunan. Kemudian akan dilakukan proses pembuatan sabun dan juga cara mencuci tangan dengan baik dan benar. Diakhir sesi pelatihan diadakan post test kegiatan untuk mengukur tingkat pemahaman dari siswa atas materi yang disampaikan dan didapatkan hasil bahwa terjadi peningkatan pemahaman siswa setelah membandingkan hasil pretest dan post test.
Co-Authors Ahmad Shobrun Jamil Bilgis Nurfatiyah, Rize Dina Siti Rahma M. Hentu Engrid Juni Astuti Hentu, Dina Siti Rahma M. Huda Prastyo, Miftahul Ikka Choirun Nisa, Vasda Muchlisin, M. Artabah Pertiwi, Cinta Junaidi Putri Purwanto, Septiana Tita Puspitasari, Chenchen Rika, Wenni Fista Rohmaturrizqi, Arvil wahyuni, reni sri Yesica, Yeni