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All Journal Food Science and Technology Journal (Foodscitech) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal EduHealth
Rafikayanti, Agustin
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Agriculture, Biological Sciences & Forestry Health Professions Medicine & Pharmacology Public Health Veterinary

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THE ANTIOXIDANT ACTIVITY COMPARISON OF MANALAGI APPLE FRUIT (Malus Sylvestris Mill) AND ITS PROCESSED PRODUCTS IN BATU CITY WITH ABTS METHOD Astuti, Engrid Juni; Rafikayanti, Agustin; Purwanto, Septiana Tita; Puspitasari, Chenchen; Rika, Wenni Fista; Yesica, Yeni
Food Science and Technology Journal (Foodscitech) Vol. 4 No. 2 (2022): FOODSCITECH
Publisher : Universitas Dr Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25139/fst.v4i2.4143

Abstract

Chemical compounds that can donor one or more electrons to free radicals to inhibit free radical reactions are called antioxidants. Manalagi apple is a fruit with high antioxidant activity. Manalagi apple is a typical fruit of Batu City. Processed apple products are apple cider, vinegar, dodol, and chips. These products are sold in Batu city and produced the same home industry. The aim of this study was to determine the antioxidant activity comparison between Manalagi apple and four processed apple products based on IC50 values. This study used the ABTS method (2,2-azino bis (3-ethyl benzothiazoline-6-sulfonic acid) and analysis used spectrophotometric visible. IC50 value as apples and their processed products were analyzed using a one-way ANOVA. The study results indicated that IC50 value of Manalagi apple was insignificantly different from the processed apple product of dodol and chips. However, the IC50 value of manalagi apple was significantly different from apple cider and vinegar.
PEMANFAATAN SENYAWA METABOLIT SEKUNDER KAWISTA (Limonia acidissima) UNTUK PENGELOLAAN DIABETES: TINJAUAN ANALISIS JEJARING FARMAKOLOGI Hentu, Dina Siti Rahma M.; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6964

Abstract

This study aims to explore the potential of secondary metabolite compounds from the kawista plant (Limonia acidissima) as antidiabetic agents through an in silico approach. We utilized pharmacological network analysis and analysis of the most important proteins to identify potential protein targets and signaling pathways involved in diabetes regulation. The analysis revealed that secondary metabolite compounds from kawista have the potential to affect various crucial aspects of glucose and lipid metabolism in the body, including through interactions with key proteins such as AKT1. These findings provide new insights into the development of additional therapies for diabetes treatment, and demonstrate the potential of in silico methods in accelerating the discovery and development of new drugs.
Potential Activity Of Secondary Metabolites Of Kawista (Limonia Acidissima) As Neurodegenerative Diseases : A Network Pharmacology Approaches Dina Siti Rahma M. Hentu; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Abstract

Kawista (Limonia acidissima) is a tropical plant traditionally used in South and Southeast Asian medicine, and its known for its rich nutritional profile and bioactive compounds. This study explores the therapeutic potential of kawista for neurodegenerative diseases. This study aims to investigate the potential of kawista in managing neurodegenerative through a pharmacological network approach. Proteins that can interact with secondary metabolites of kawista were predicted using SwissTargetPrediction, proteins related to neurodegenerative were obtained from GeneCards. The intersecting results were analyzed using STRING with GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment methods. From 47 secondary metabolites of kawista, 218 neuro-related proteins was identified potentially interacting with kawista's secondary metabolites. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and disease-gene association analyses highlighted key biological processes, molecular functions, cellular components, and pathways relevant to neurodegenerative disease mechanisms. The findings suggest that kawista's bioactive compounds could modulate critical pathways and receptor activities, offering insights into developing novel, effective therapies for neurodegenerative disorders. This research providing a scientific basis for kawista-based therapeutic strategies aimed at improving neurodegenerative disease outcomes.
Co-Authors Ahmad Shobrun Jamil Dina Siti Rahma M. Hentu Engrid Juni Astuti Hentu, Dina Siti Rahma M. Muchlisin, M. Artabah Purwanto, Septiana Tita Puspitasari, Chenchen Rika, Wenni Fista Yesica, Yeni