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All Journal Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Martabe : Jurnal Pengabdian Kepada Masyarakat Eksakta : Berkala Ilmiah Bidang MIPA Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai Jurnal EduHealth Borneo Journal of Pharmacy
Muchlisin, M. Artabah
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Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Analisis Jejaring Farmakologi Tanaman Jati Belanda (Guazuma ulmifolia Lamk.) Sebagai Imunomodulator Lena, Nour; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah; Almutahrihan, Irsan Fahmi
Journal of Islamic Pharmacy Vol 8, No 1 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i1.20782

Abstract

Covid-19 merupakan wabah penyakit yang menginfeksi sistem pernafasan pada manusia. Kasusnya terjadi hampir di seluruh negara di dunia dan keberadaannya sangat meresahkan karena penyebarannya terjadi dengan sangat cepat. Salah satu upaya yang dapat dilakukan untuk mencegah penyebaran penyakit Covid-19 adalah dengan meningkatkan sistem imun. Sistem imun melindungi tubuh dari infeksi dengan memproduksi molekul protein yang disebut antibodi yang mengikat antigen agen infeksi. Berdasarkan studi literatur yang telah dilakukan, beberapa tanaman lokal Indonesia memiliki potensi sebagai imunomodulator. Fokus penelitian ini ditujukan untuk mengetahui jejaring protein yang terkait dengan sistem imun tubuh yang teraktivasi karena pemberian ekstrak tanaman jati belanda (Guazuma ulmifolia Lamk.). Metode penelitian yang digunakan adalah deskriptif eksploratif berdasarkan online database dan web server (KNApSAck Family, Dr. Duke’s Phytochemical and Ethnobotanical Databases, SwissTargetPrediction, GeneCards, SwissADME, Venny, dan StringDB). Berdasarkan hasil penelitian, tanaman G. ulmifolia mengandung 17 senyawa metabolit sekunder, lima diantaranya memiliki bioavailabilitas yang tinggi meliputi ent-catechin, (-)-epigallocatechin, caffeine, kaempferol, dan quercetin. Senyawa (-)-epigallocatechin diprediksi dapat berinteraksi dengan MAPK14 yang memiliki koneksi dengan lima jalur penting dalam imunomodulator yaitu Fc epsilon RI signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, THF17 cell differentiation, TNF signaling pathway, dan IL-17 signaling pathway.
ANALISIS KETERKAITAN NETWORK PHAMACOLOGY SENYAWA METABOLIT SEKUNDER Abrus precatorius L. SECARA IN SILICO Khoirunnisa, Azka; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah
Jurnal Penelitian Farmasi Dan Herbal Vol 6 No 2 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i2.1686

Abstract

Cancer remains a global health challenge, prompting extensive research efforts worldwide. Lung cancer, the second most diagnosed cancer, presents a particularly grim survival rate. In Indonesia, cancer incidence ranks significantly, with millions affected and hundreds of thousands succumbing to the disease annually. Traditional medicine persists as a preferred option among many, perceived as safer and more affordable. Abrus precatorius L., an ancient medicinal plant, holds promise in this regard, with a rich history of use and a diverse range of pharmacological activities, including anti-cancer properties. Employing in silico modeling and network pharmacology, this study explores the interaction between Abrus precatorius L. compounds and various proteins associated with cancer. Through bioinformatics tools and databases, 27 bioactive compounds are identified and their physicochemical properties assessed, ensuring adherence to pharmacological guidelines. The study predicts potential protein targets for Abrus precatorius L. compounds, revealing interactions with 453 proteins, including those implicated in cancer pathways. Further analysis using StringDB and DISEASES database establishes protein-protein interaction networks, highlighting key proteins like EGFR and TERT, pivotal in multiple cancer types. The study validates the compounds' adherence to Lipinski's Rule of Five, indicating their potential for pharmacological activity and oral absorption. False Discovery Rate (FDR) analysis confirms significant associations between Abrus precatorius L. compounds and various cancers, further underscoring their therapeutic potential. In conclusion, Abrus precatorius L. compounds, particularly targeting EGFR and TERT proteins, emerge as promising candidates for cancer treatment. Their diverse pharmacological activities and interactions with key cancer-related proteins pave the way for further exploration and development of these compounds as alternative medicinal agents. In vitro and in vivo studies are warranted to validate their efficacy, particularly in addressing the complexities of different cancer types. Ultimately, this research offers valuable insights into leveraging natural compounds for combating cancer, addressing a critical need in global healthcare.
PEMANFAATAN SENYAWA METABOLIT SEKUNDER KAWISTA (Limonia acidissima) UNTUK PENGELOLAAN DIABETES: TINJAUAN ANALISIS JEJARING FARMAKOLOGI Hentu, Dina Siti Rahma M.; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6964

Abstract

This study aims to explore the potential of secondary metabolite compounds from the kawista plant (Limonia acidissima) as antidiabetic agents through an in silico approach. We utilized pharmacological network analysis and analysis of the most important proteins to identify potential protein targets and signaling pathways involved in diabetes regulation. The analysis revealed that secondary metabolite compounds from kawista have the potential to affect various crucial aspects of glucose and lipid metabolism in the body, including through interactions with key proteins such as AKT1. These findings provide new insights into the development of additional therapies for diabetes treatment, and demonstrate the potential of in silico methods in accelerating the discovery and development of new drugs.
Potential Activity Of Secondary Metabolites Of Kawista (Limonia Acidissima) As Neurodegenerative Diseases : A Network Pharmacology Approaches Dina Siti Rahma M. Hentu; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kawista (Limonia acidissima) is a tropical plant traditionally used in South and Southeast Asian medicine, and its known for its rich nutritional profile and bioactive compounds. This study explores the therapeutic potential of kawista for neurodegenerative diseases. This study aims to investigate the potential of kawista in managing neurodegenerative through a pharmacological network approach. Proteins that can interact with secondary metabolites of kawista were predicted using SwissTargetPrediction, proteins related to neurodegenerative were obtained from GeneCards. The intersecting results were analyzed using STRING with GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment methods. From 47 secondary metabolites of kawista, 218 neuro-related proteins was identified potentially interacting with kawista's secondary metabolites. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and disease-gene association analyses highlighted key biological processes, molecular functions, cellular components, and pathways relevant to neurodegenerative disease mechanisms. The findings suggest that kawista's bioactive compounds could modulate critical pathways and receptor activities, offering insights into developing novel, effective therapies for neurodegenerative disorders. This research providing a scientific basis for kawista-based therapeutic strategies aimed at improving neurodegenerative disease outcomes.
In Silico Study Potential Secondary Metabolite Candidate of Citronella Grass (Cymbopogon nardus) on Immunity Cases Veda, Adella Infia Helga; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Almutahrihan, Irsan Fahmi; Satriawan, Herland
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 03 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss03/418

Abstract

Foreign invaders in the form of bacteria, fungi, or viruses can cause various diseases if they enter the body, both molecularly and cellularly. Hence, the body needs a compound that can maintain and enhance the immune and immune systems to recognize abnormal cells that can become a source of disease for the body. Improving immunity/resistance for people with diseases is very important so that people undergoing treatment are given immunostimulant drugs or pharmaceutical preparations. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of citronella (Cymbopogon nardus). The research method used is explorative descriptive with in silico analysis using a computational model with software including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, C. nardus contains 40 secondary metabolites, 25 of them have high bioavailability. Based on pharmacological network analysis, (-)-menthol is an important compound that plays a role in the immune system because it is expected to interact with three crucial pathways related to immunomodulators.
A Network Pharmacology Analysis of Secondary Metabolites of Noni (Morinda citrifolia) as Immunomodulators Helmi, M.; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah; Almuhtarihan, Irsan Fahmi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006183

Abstract

Immunomodulators are substances or compounds that can modulate or help increase the activity and function of the immune system. The medicinal use of herbal plants is now increasing again among Indonesian people. Noni (Morinda citrifolia) is a plant commonly found in Indonesia that has long been known to have many benefits for treating and preventing various diseases and the secondary metabolites have potential as immunomodulators. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of noni. The explorative descriptive research was conducted with in silico analysis using a computational model with software, including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, noni contains 128 secondary metabolites, and 83 of them have high bioavailability. Based on pharmacological network analysis, (z,z,z)-8,11,14-eicosatrienoic-acid and 1-5-6-trihydroxy-anthraquinone are important compounds that play a role in the immune system because they are expected to interact with five crucial pathways related to immunomodulators.
POTENSI KAWISTA (LIMONIA ACIDISSIMA) DALAM PENGELOLAAN HIPERTENSI : ANALISIS JEJARING FARMAKOLOGI Pertiwi, Cinta Junaidi Putri; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Jurnal Kesehatan Tambusai Vol. 5 No. 2 (2024): JUNI 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i2.28226

Abstract

Hipertensi adalah kondisi kronis yang dapat menyebabkan komplikasi kardiovaskular serius, dan kawista (L. acidissima) telah digunakan dalam pengobatan tradisional untuk berbagai penyakit, termasuk hipertensi. Namun mekanisme molekuler L. acidissima dalam mengatur tekanan darah belum sepenuhnya dipahami. Penelitian ini bertujuan untuk menyelidiki potensi kawista L. acidissima dalam pengelolaan hipertensi melalui pendekatan jejaring farmakologi. Senyawa metabolit sekunder L. acidissima diambil dari literatur, protein yang dapat berinteraksi dengan metabolit sekunder diprediksi dengan menggunakan SwissTargetPrediction, protein yang berhubungan dengan hipertensi diperoleh dari GeneCards. Hasil irisan protein dari SwissTargetPrediction dan GeneCards dianalisis lebih lanjut menggunakan STRING dengan metode GO (Gene Ontology) dan KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment. Protein yang paling memiliki peranan dalam hipertensi dianalisis dengan menggunakan algoritma MCC (Maximal Clique Centralit) dari CytoHubba. Analisis GO enrichment menunjukkan keterlibatan protein-protein dalam regulasi tekanan darah sistemik dan respons biologis lainnya yang relevan dengan hipertensi. Analisis KEGG enrichment mengungkap keterlibatan jalur-jalur sinyal utama seperti cGMP-PKG dan HIF-1, serta jalur regulasi hormonal penting dalam regulasi tekanan darah. Analisis MCC top 10 dari CytoHubba menyoroti peran sentral gen-gen seperti ACE, NOS3, dan EDNRA dalam jaringan biologis, menunjukkan potensi mereka sebagai target terapeutik dalam pengelolaan hipertensi. Senyawa metabolit sekunder L. acidissima memiliki potensi digunakan sebagai terapi untuk hipertensi.
Integrative Network Pharmacology Unveils Limonia acidissima as a Potential Natural Product for Targeting Cancer Wahyuni, Reni Sri; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6988

Abstract

Cancer remains a formidable health challenge worldwide, with complex molecular mechanisms driving its initiation, progression, and therapeutic resistance. In this study, we employed bioinformatics analyses to elucidate the molecular underpinnings of cancer biology, focusing on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Our GO analysis revealed the enrichment of key biological processes such as protein phosphorylation, regulation of programmed cell death, and transmembrane receptor signaling pathways, underscoring the critical roles of signaling cascades and regulatory mechanisms in tumorigenesis. Similarly, molecular functions such as protein kinase activity and ATP binding were identified as significantly enriched, highlighting the importance of protein kinases and molecular interactions in cancer development and progression. The KEGG pathway analysis further delineated dysregulated signaling pathways associated with cancer, including the MAPK and PI3K-Akt signaling pathways, implicating these pathways as central regulators of cancer progression. These findings deepen our understanding of cancer biology and offer potential targets for therapeutic intervention. Integrating multi-omics data and systems biology approaches may provide deeper insights into the intricate networks underlying cancer pathogenesis, paving the way for developing more effective treatments for cancer patients.
Thiourea Derivatives as Estrogen Receptor Alpha Inhibitors for Breast Cancer Therapy: An In Silico Evaluation with ADMET Prediction and Molecular Docking Puspaweni, Hestining; Purwanto, Bambang Tri; Widiandani, Tri; Siswodihardjo, Siswandono; Muchlisin, M. Artabah
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.7396

Abstract

Breast cancer remains a significant public health concern, necessitating the discovery of novel therapeutic agents. This study investigates the potential of thiourea derivatives, specifically HU, HTMX, and BMPTU compounds, as estrogen receptor alpha (ERα) inhibitors using computational approaches. Drug-likeness assessments using Lipinski's Ro5 confirmed the oral bioavailability of all compounds. Additionally, ADMET analysis indicated favorable pharmacokinetic properties, with minimal metabolic interactions and acceptable safety profiles, except for BMPTU2, which showed potential hepatotoxicity. Molecular docking simulations revealed strong binding affinities between BMPTU derivatives, particularly BMPTU2, BMPTU3, and BMPTU4, and key ERα residues. These interactions suggest their potential as ERα modulators, warranting further in silico and experimental validation. In conclusion, the findings highlight the potential of BMPTU derivatives, especially BMPTU2, BMPTU3, and BMPTU4, as promising lead compounds for developing novel ERα-targeted breast cancer therapies. Further optimization and validation are crucial to fully elucidate their therapeutic potential.
IbM PEMBUATAN SABUN CUCI TANGAN UNTUK MENCEGAH PENULARAN VIRUS COVID 19 PADA MASA PANDEMI Juni Astuti, Engrid; Rafikayanti, Agustin; Muchlisin, M. Artabah; Rohmaturrizqi, Arvil; Bilgis Nurfatiyah, Rize; Huda Prastyo, Miftahul; Ikka Choirun Nisa, Vasda
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 7 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i7.2562-2569

Abstract

IbM kali ini menggunakan mitra siswa sekolah menengah SMP Muhammadiyah 4 Singosari. Sekolah menengah ini berada di jalur protokol Singosari dan lokasi yang sangat strategis karena berada didekat pusat kecamatan Singosari. SMP ini terdiri dari kelas I sampai dengan kelas III dengan jumlah siswa total sekitar 150 siswa yang terbagi menjadi 6 kelas belajar. Disini pengabdi akan melakukan pelatihan terhadap siswa sekolah kelas 2 untuk membuat sabun cuci tangan yang bisa digunakan untuk mencegah penularan virus COVID-19 pada saat pandemi. Jumlah siswa kelas 2 yang mengikuti kegiatan berjumlah sekitar 25 orang siswa beserta guru pendamping kelas. Saat ini seperti yang kita ketahui pada masa pandemi bahwa penyebaran virus COVID-19 sangat tinggi dan fluktuatif. Hingga tahun 2022 pulau jawa masih mengharuskan pembatasan aktifitas sosial di masyarakat, serta untuk kegiatan pembelajaran sampai tahun 2022 masih dibatasi dengan media Daring. Pencegahan Covid pada masa itu masih disarankan menggunakan masker, sering mencuci tangan dan menjaga jarak. Untuk mencuci tangan seperti yang kita ketahui selain handsanitizer yang digunakan dalam keadaan darurat maka harus digunakan sabun cuci tangan. Dalam proses pendampingan siswa akan dilakukan awal dengan pemberian pretest tentang dasar pembuatan sabun dan teori kimia yang mendasari proses penyabunan. Kemudian akan dilakukan pemberian materi berupa teknik bagaimana cara pembuatan sabun beserta teori yang mendasari teknik penyabunan. Kemudian akan dilakukan proses pembuatan sabun dan juga cara mencuci tangan dengan baik dan benar. Diakhir sesi pelatihan diadakan post test kegiatan untuk mengukur tingkat pemahaman dari siswa atas materi yang disampaikan dan didapatkan hasil bahwa terjadi peningkatan pemahaman siswa setelah membandingkan hasil pretest dan post test.
Co-Authors Ahmad Shobrun Jamil Almutahrihan, Irsan Fahmi Azka Khoirunnisa Bambang Tri Purwanto Bilgis Nurfatiyah, Rize Dina Siti Rahma M. Hentu Engrid Juni Astuti Hentu, Dina Siti Rahma M. Huda Prastyo, Miftahul Ikka Choirun Nisa, Vasda Irsan Fahmi Almuhtarihan Lena, Nour M. Helmi Pertiwi, Cinta Junaidi Putri Puspaweni, Hestining Rafikayanti, Agustin Rohmaturrizqi, Arvil Satriawan, Herland Siswandono, Siswandono Tri Widiandani Veda, Adella Infia Helga wahyuni, reni sri