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All Journal Journal of Tropical Biodiversity and Biotechnology JSMARTech : Journal of Smart Bioprospecting and Technology
Rijalullah, Muhammad Asyraf
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Virtual Screening of Mimosa pudica Secondary Metabolites as Hyaluronidase B Potential Inhibitor to Prevent Vespa velutina Venom Spreading Rijalullah, Muhammad Asyraf; Pramudya, Muhammad Alif Imam; Maisuroh, Dalilatul; Zain, Dhiyaa Syahlaa Bianca Febrinnisa; Kurniawan, Nia; Fatchiyah, Fatchiyah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 3 (2021)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2021.002.03.96

Abstract

Vespa velutina, also known as the Yellow-legged hornet, is a wasp species native to Asia with a large distribution area in Indonesia. Hyaluronidase B in a wasp venom acts as a "spreading factor", which is the key at the beginning of envenomation. Shameplant (Mimosa pudica), a common plant in Indonesia, has shown the potential to be a hyaluronidase B inhibitor. This study aimed to analyze the potential of secondary metabolites in Shameplant as an inhibitor of V. velutina Hyaluronidase B base on their molecular interactions and as a topical drug base on physicochemical characteristics. In silico computational studies is performed to predict the binding modes of M. pudica compounds and hyaluronidase B enzyme. The secondary metabolites were retrieved from the PubChem database and screened using SwissADME. The seven metabolite compounds were docked with Hyaluronidase B and hyaluronan by HEX Cuda 8.0.0 program. Hyaluronidase B was also docked with its native ligand (hyaluronan) to validate the docking study. Three dimensional and 2D views were then evaluated using Discovery Studio 2016. Results of this study are all compounds do not have the same molecular interaction with the control. It defines no inhibition of the interaction on the active side. Mimopudine is the most potent inhibitor of hyaluronidase B based on its binding energy. While, jasmonic acid is the only compound that meets the physicochemical parameter of the topical drug.
Habitat suitability modelling of Rhacophorus reinwardtii (Schlegel, 1840) in Java, with notes on habitat characteristics from Malang, East Java Kurniawan, Nia; Fathoni, Muhammad; Assiddiqy, Miftah Farid; Septiadi, Luhur; Rijalullah, Muhammad Asyraf
Journal of Tropical Biodiversity and Biotechnology Vol 9, No 2 (2024): June
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.84459

Abstract

The distribution of the Reinwardt's Gliding Frog, Rhacophorus reinwardtii (Schlegel, 1840), was recently thought to be restricted in Java. Furthermore, the constant and rapid deforestation in Java highlight the significance of the frog's habitat requirements in establishing the accurate species' conservation status. This study aims to predict the suitable habitat for this species in Java and to identify the habitat characteristics in Malang Region-East Java. Using the Maximum Entropy (MaxEnt) approach, we modelled the distribution of species and examined numerous types of breeding sites in Malang Region. Our findings revealed that the species inhabits a much more restricted and fragmented habitat in Java, where it inhabits both forest and agroforestry areas. 
Co-Authors Assiddiqy, Miftah Farid fatchiyah . Maisuroh, Dalilatul Muhammad Fathoni, Muhammad Nia Kurniawan Pramudya, Muhammad Alif Imam Septiadi, Luhur Zain, Dhiyaa Syahlaa Bianca Febrinnisa