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All Journal Indonesian Journal of Pharmacology and Therapy Bulletin of Inspiring Developments and Achievements in Midwifery
Anna Maria Manullang
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology

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Clinical trial and therapeutical progress of COVID-19 treated with remdesivir: A review Anna Maria Manullang; Monia Agni Wiyatami; Mahulauw, Muhammad Azril Hardiman
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021): Special Issue: COVID-19
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.2625

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that first reported in Wuhan City, China. Most confirmed cases of COVID-19 develop mild, moderate, severe to critical symptoms. One of the therapies given and of concern is remdesivir. Remdesivir is an antiviral with a broad spectrum that has activity against various types of viruses including Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV. The aim of this review was to evaluate the clinical trial and the therapeutical progress of remdesivir in the treatment of COVID-19 patients. Databases used for this review were Google Scholar, JAMA, PubMed and Science Direct library. The inclusion criteria were covering any literature using remdesivir in clinical studies and COVID-19 therapy published from December 2019 to October 2020. Overall no pattern of laboratory abnormalities and clinically significant changes in vital signs or ECG shifts was observed in patients receiving remdesivir. The decision to use remdesivir in COVID-19 treatment should consider its potential benefits and risks.
Factors Related to Mothers and the Prevalence of LBW Ni Komang Erny Astiti; Ni Wayan Suarniti; Visti Delvina; Anna Maria Manullang; Inna Noor Inayati
Bulletin of Inspiring Developments and Achievements in Midwifery Vol. 1 No. 1 (2024): December, 2024
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/bidan.v1i1.79

Abstract

Birth weight is a crucial indicator of infant health, influencing survival and future growth and mental development. In 2020, 40 mothers (7.19%) experienced preeclampsia during childbirth. Among mothers giving birth, 216 (39%) were primiparous, 300 (54%) multiparous, and 40 (7.19%) grand multiparous. This study aimed to identify maternal factors associated with the prevalence of low birth weight (LBW) in hospitals. Utilizing a case-control research design, this quantitative study employed an observational analytical method. The sample consisted of 60 controls and 30 cases of LBW infants, randomly selected from mothers who delivered between January and December. Data were analyzed using bivariate chi-square tests.The analysis revealed a significant relationship between preeclampsia and LBW incidence, with a prevalence ratio (PR) of 2.667 (95% CI = 1.591-4.470). To mitigate LBW rates, the Indonesian Ministry of Health has established health check-up guidelines for pregnant women. This initiative aims to enhance hospital programs addressing factors that contribute to LBW. Additionally, variables such as parity, anemia, and nutritional status did not show a significant correlation with LBW incidence.In conclusion, while preeclampsia was significantly linked to LBW, other maternal factors such as parity and nutritional status require further investigation to understand their potential impacts on birth weight outcomes effectively. The findings underscore the importance of comprehensive maternal healthcare to improve neonatal health outcomes and reduce the prevalence of LBW in future pregnancies.
Co-Authors Inna Noor Inayati Mahulauw, Muhammad Azril Hardiman Monia Agni Wiyatami Ni Komang Erny Astiti Ni Wayan Suarniti Visti Delvina