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All Journal International Journal of Integrated Health Sciences Majalah Biomorfologi (Biomorphology Journal) Malang Respiratory Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Rakasiwi, Muhammad Ilham Dhiya
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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ASCORBIC ACID SUPPLEMENTATION FOR ADJUNCTIVE TREATMENT OF PULMONARY TUBERCULOSIS: REVIEW OF LABORATORY RESEARCH AND CLINICAL TRIALS IN INDONESIA Rakasiwi, Muhammad Ilham Dhiya; Taufik, Muhammad; Aristyo, Kevin; Wandawa, Azlina D; Burhan, Erlina; Kurniawan, Gerry; Ferian, Muhammad Farel
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1110

Abstract

Background: Tuberculosis (TB) is a highly lethal global disease caused by Mycobacterium tuberculosis (Mtb), which has affected approximately a quarter of the world's population. Ascorbic acid is acknowledged for its strong antioxidant properties, its ability to modulate the immune system, and its effectiveness against Mtb infections. Method: Literature search based on specific keywords following the PICO (Patient, Intervention, Comparison, Outcome) research question was carried out on Pubmed, Scopus and Google Scholar databases, as well as Garuda for clinical research in Indonesia. The flow of the literature search followed PRISMA and risk of bias analysis using the Rob2 tool. Discussion: Laboratory studies have shown that ascorbic acid, whether given by itself or in conjunction with standard anti-TB medications, can decrease the quantity of Mtb colony-forming units (CFU). Similar outcomes were witnessed in experiments conducted with mice. The administration of ascorbic acid to mice infected with Mtb also led to a reduction in lung tissue damage. Clinical trials carried out in Indonesia demonstrated that the addition of ascorbic acid resulted in a greater sputum conversion rate in comparison to patients who did not receive this supplementation. Conclusion: Ascorbic acid exhibits several clinical attributes that prove beneficial in the management of TB.
Differential White Blood Cell Count and COVID-19 Hospital Length of Stay: A Post-hoc Analysis Gustya, Gita Fajri; Nugraha, Darrin Ananda; Rakasiwi, Muhammad Ilham Dhiya; Azzumar, Farchan; Burhan, Erlina
International Journal of Integrated Health Sciences Vol 12, No 2 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v12.n2.3915

Abstract

Objective: To explore the association between differential white blood cell count and hospital length of stay (LOS) in COVID-19 patients.Methods: This study is a post-hoc analysis of two prospective cohort studies involving hospitalized COVID-19 patients who received standard therapy, including antiviral and supportive treatments at Persahabatan Hospital, Jakarta, Indonesia, during the Delta and Omicron dominant pandemic periods. Baseline differential white blood cell count before initiation of therapy were documented. LOS was categorized as ≤10 days and >10 days.Result: Data from 463 subjects were included with most subjects were males (62.2%) with a median age of 54 (14–93) years. The average LOS for subjects was 12.7 (12.1–13.4) days. Bivariate tests showed that lymphocytes, neutrophils, monocytes, neutrophil-lymphocyte ratio (NLR), and neutrophil-monocyte ratio (NMR) had significant association (p <0.05) to LOS. Logistic regression showed that higher monocyte counts were associated with shorter LOS (adjusted OR 0.89; 95% CI 0.840 - 0.943; p < 0.001). ROC curve showed that higher monocyte counts (>8.35 × 10^3/µL) at admission may predict shorter hospitalization (<10 days).Conclusion: Monocyte count may serve as a potential marker for length of stay in COVID-19 patients, offering key insights for optimizing patient management and resource allocation.
Investigating the Prospect of C-Type Lectin-like Receptors-2 for Predicting Prognosis of Ischemic Stroke: Rapid Review of Molecular Mechanisms to Clinical Study Farandy, Rayhan; Rakasiwi, Muhammad Ilham Dhiya; Amaanullah, Muhammad Zaki Bariz; Khatimah, Nurul Gusti
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.157-165

Abstract

Highlights The potential of CLEC-2 as a prognostic biomarker for ischemic stroke is supported by in vivo and clinical studies demonstrating its role in thrombo-inflammatory mechanisms and clinical outcome prediction. Analysis of clinical studies indicates that elevated plasma CLEC-2 levels are associated with an increased risk of recurrent vascular events and mortality in acute ischemic stroke, suggesting its promise as a noninvasive tool for stroke prognosis assessment.   ABSTRACT Background: Every year, over 13.7 million individuals experience strokes, resulting in approximately 5.8 million deaths. C-type lectin-like receptor 2 (CLEC-2) plays a significant role in platelet activation, which is elevated in ischemic stroke and is associated with disease progression and prognosis. Objective: To review the literature on the potential of CLEC-2 as a biomarker for assessing the prognosis and progression of ischemic stroke. Material and Method: This rapid review followed the Cochrane interim guidelines and adhered to PRISMA standards. A comprehensive search was conducted in PubMed, Cochrane Library, and Google Scholar to identify original research articles published in English over the past 10 years. Studies at various stages—including in vitro, in vivo, and clinical trials—were included if they evaluated the association between CLEC-2 and acute ischemic stroke. Risk of bias was assessed using the QUIPS tool for clinical studies and SYRCLE’s tool for animal studies. Study selection and data extraction were performed independently by three reviewers. Result: The search identified five relevant articles: two experimental studies and three clinical prognostic studies examining CLEC-2 in the context of ischemic stroke. CLEC-2, a receptor for podoplanin expressed in various tumors and lymphatic endothelial cells, induces a calcium surge independent of secondary platelet activation. In vivo studies have demonstrated increased levels of CLEC-2 and podoplanin, which are highly expressed on neurons and microglia in ischemic brain regions. The three clinical studies showed that plasma CLEC-2 levels have prognostic value in predicting recurrent vascular events and mortality in patients with acute ischemic stroke. Conclusion: Plasma CLEC-2 shows potential as a biomarker for evaluating the progression and prognosis of acute ischemic stroke.
PENGARUH PANDEMI COVID-19 DAN PEMBATASAN SOSIAL TERHADAP PASIEN Rakasiwi, Muhammad Ilham Dhiya
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.512

Abstract

Background:
Pengenalan Awal Pneumonia Komunitas Resiko Tinggi yang Berkembang menjadi Sepsis pada Pasien Geriatri Renta: Sebuah Laporan Kasus Aini, Nurul; Rakasiwi, Muhammad Ilham Dhiya; Riyatno, Imron; Huda, Muhammad Addinul
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 2 No. 1 (2024)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol2.iss1.art7

Abstract

Sepsis adalah disfungsi organ yang mengancam jiwa yang disebabkan oleh respon tubuh yang tidak teratur terhadap infeksi. Sepsis dapat terjadi akibat infeksi yang didapat komunitas atau layanan kesehatan ,dengan pneumonia terhitung lebih dari 50% kejadian sepsis pada pasien dirawat di unit perawatan intensif rumah sakit. Angka mortalitas sepsis pada geriatri dengan community-acquired pneumonia (CAP) berada antara 14% dan 26%. Pasien wanita usia 82 tahun dibawa ke IGD karena sesak napas yang memberat 1 hari sebelumnya. Pasien didiagnosis community-acquired pneumonia dengan komorbid dan status fungsional rendah yang berkembang menjadi sepsis. Pasien dirawat di unit perawatan intensif dengan memberptimbangkan skor CURB-65, PSI dan NLR. dan mendapatkan terapi cairan dan monitor balans, double antibiotic dan penanganan multidisiplin dari dokter anestesi, dokter neurologi dan dokter jantung. Setelah mendapatkan penangan optimal dan intensif, pasien meninggal pada hari ke-7 perawatan. Pneumonia dan sepsis pada pasien geriatri merupakan tantangan tersendiri yang membutuhkan pendekatan diagnosis dan resusitasi yang tepat dan cepat. Target penanganan sepsis sesegera mungkin adalah menurunkan angka mortalitas dan morbiditas pasien. Kata Kunci: Pneunomonia Komunitas, Geriatri, Renta, Sepsis
Chronic Obstructive Pulmonary Disease Exacerbation Complicated with Pneumonia and Lung Cancer: An Evidence-based Case Report of Erdosteine Role in the Management of Complex COPD Ilham, Ahmad Fadhil; Rakasiwi, Muhammad Ilham Dhiya; Felim, Ris Raihan; Arfan, Ahmad; Burhan, Erlina
Malang Respiratory Journal Vol. 6 No. 2 (2024): September 2024
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2024.006.02.05

Abstract

Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are strongly associated with poor health status and morbidity. Erdosteine is a mucolytic agent that also has anti-inflammatory, antioxidant and antibacterial effects. This case report aims to evaluate the role of erdosteine in the prevention and treatment of acute exacerbations of complex COPD case. Case: A 73-year-old male arrived at the emergency department with an increased difficulty in breathing that had deteriorated over the previous 5 days, and had a history of heavy smoking for more than 40 years. Following a thorough examination, he was diagnosed with acute exacerbation of COPD (Anthonisen criteria type 2) in clinical group E, pneumonia, along with stage IIIA right lung tumor (T4N1Mx), and received erdosteine inhalation as part of his treatment. Discussion: A comprehensive search of journal databases (PubMed, EMBASE, CENTRAL, EBSCO Medline, Scopus, and ProQuest) was conducted using specific keywords, critical appraisal based on the Oxford Center for Evidence-Based Medicine. Article selection resulted in 1 systematic review article for the prevention of acute exacerbations and 1 systematic review article for the management of acute exacerbations of COPD. In patients with stable COPD, administration of erdosteine in the standard COPD regimen significantly reduced the risk of exacerbations (RR=0.65; p=0.01), while in patients with acute exacerbations of COPD, erdosteine increased treatment success (OR=3.2; p<0.0001). Conclusion: Erdosteine may serve as a therapeutic choice for COPD patients in preventing or managing acute exacerbations.
Co-Authors Aini Nurul Amaanullah, Muhammad Zaki Bariz Arfan, Ahmad Aristyo, Kevin Azzumar, Farchan Erlina Burhan Farandy, Rayhan Felim, Ris Raihan Ferian, Muhammad Farel Gustya, Gita Fajri Huda, Muhammad Addinul Ilham, Ahmad Fadhil Khatimah, Nurul Gusti Kurniawan, Gerry MUHAMMAD TAUFIK Nugraha, Darrin Ananda Riyatno, Imron Wandawa, Azlina D