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ASCORBIC ACID SUPPLEMENTATION FOR ADJUNCTIVE TREATMENT OF PULMONARY TUBERCULOSIS: REVIEW OF LABORATORY RESEARCH AND CLINICAL TRIALS IN INDONESIA Rakasiwi, Muhammad Ilham Dhiya; Taufik, Muhammad; Aristyo, Kevin; Wandawa, Azlina D; Burhan, Erlina; Kurniawan, Gerry; Ferian, Muhammad Farel
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1110

Abstract

Background: Tuberculosis (TB) is a highly lethal global disease caused by Mycobacterium tuberculosis (Mtb), which has affected approximately a quarter of the world's population. Ascorbic acid is acknowledged for its strong antioxidant properties, its ability to modulate the immune system, and its effectiveness against Mtb infections. Method: Literature search based on specific keywords following the PICO (Patient, Intervention, Comparison, Outcome) research question was carried out on Pubmed, Scopus and Google Scholar databases, as well as Garuda for clinical research in Indonesia. The flow of the literature search followed PRISMA and risk of bias analysis using the Rob2 tool. Discussion: Laboratory studies have shown that ascorbic acid, whether given by itself or in conjunction with standard anti-TB medications, can decrease the quantity of Mtb colony-forming units (CFU). Similar outcomes were witnessed in experiments conducted with mice. The administration of ascorbic acid to mice infected with Mtb also led to a reduction in lung tissue damage. Clinical trials carried out in Indonesia demonstrated that the addition of ascorbic acid resulted in a greater sputum conversion rate in comparison to patients who did not receive this supplementation. Conclusion: Ascorbic acid exhibits several clinical attributes that prove beneficial in the management of TB.
Designing an Information Media on the Impact of Excessive Social Media Use on Adolescents’ Mental Health Disorders Kurniawan, Gerry; Ditto, Anin
Jurnal Desain Komunikasi Visual Vol. 2 No. 3 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/dkv.v2i3.4424

Abstract

This study explores the impact of excessive social media use on adolescent mental health, particularly among high school students in Padang Panjang, Indonesia. As digital technologies become more embedded in daily life, adolescents increasingly spend extended periods online, often unaware of the psychological consequences. The study employed a qualitative descriptive method supported by surveys, interviews, observations, and literature review. Data were collected from students, school counselors, and clinical psychologists, revealing that excessive social media use is strongly correlated with symptoms such as anxiety, depression, social withdrawal, and emotional instability. In response, the study designed an educational illustrated book titled Behind the Screen, aimed at increasing awareness and promoting healthy digital habits among youth. The visual strategy utilized relatable character illustrations and simplified language to communicate the risks of digital overuse and mental health decline. The results suggest that targeted visual media can serve as an effective tool to support mental health literacy and behavior change in adolescent communities