Article Per Year (5 Year)
p-Index From 2021 - 2026
0.778
P-Index
This Author published in this journals
All Journal MNJ (Malang Neurology Journal) AKSONA
Pikatan, Orlando
Unknown Affiliation
Medicine & Pharmacology Neuroscience

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Atypical Presentation of Rheumatic Fever: Isolated Hemichorea with Subclinical Carditis and No Joint Involvement Pikatan, Orlando; Putri, Dian Kusumastuti Anggraeni; Trisnawati, Sri Yenni; Widyantara, I Wayan; Lavenia, I Gusti Agung Ayu Gita
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.71139

Abstract

Highlight: The clinical manifestation of the Sydenham chorea The mechanism of hemichorea in Sydenham chorea involves the antigen found throughout the body.   ABSTRACT Introduction: Rheumatic fever (RF) is an autoimmune inflammatory disease that develops as a complication of a previous infection with group A beta-hemolytic Streptococcus (GABHS), typically following episodes of tonsillopharyngitis. Although its prevalence has decreased due to advances in medical treatment and improved living conditions, RF remains a major health issue in developing countries. Sydenham chorea (SC) is a well-known neurological complication of RF, which occasionally presents as hemichorea, a rare condition affecting only one side of the body. Therefore, early identification is important for initiating treatment promptly and preventing further complications.  Case: A 12-year-old boy presented with involuntary, dance-like movements on the left side, following a fever. Laboratory tests showed elevated inflammatory markers and ASTO titers, suggesting a prior streptococcal infection. Imaging revealed left-sided pneumonia. Brain scans were normal, but echocardiography revealed mild mitral regurgitation, indicating subclinical carditis. The patient was diagnosed with RF complicated by hemichorea and was subsequently treated with benzathine penicillin, ceftriaxone, haloperidol, and valproic acid. Increasing the valproic acid dosage effectively resolved the symptoms. Conclusion: Rheumatic fever should be considered in children presenting with hemichorea, even in the absence of joint involvement or overt cardiac symptoms. Early diagnosis, adherence to the 2015 revised Jones criteria, and long-term antibiotic prophylaxis are crucial to prevent disease recurrence and complications.
HIGH RISK OF OBSTRUCTIVE SLEEP APNEA, OBESITY, MELATONIN LEVELS, AND C-REACTIVE PROTEIN IN INDIVIDUALS WITH AND WITHOUT DIABETES MELLITUS: A COMPARATIVE STUDY Indrasari Utami, Desak Ketut; Saraswati, Made Ratna; Ariyanti Putri, Putu Dian; Yustiantara, Putu Sanna; Pikatan, Orlando
MNJ (Malang Neurology Journal) Vol. 12 No. 2 (2026): July (ARTICLE IN PRESS)
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.02.1

Abstract

Background: Sleep is a fundamental pillar for maintaining metabolic, endocrine, and cardiovascular stability. However, individuals diagnosed with Type 2 Diabetes Mellitus (T2DM) are disproportionately susceptible to sleep-related disorders, particularly Obstructive Sleep Apnea (OSA). This relationship is often bidirectional, where sleep disturbances can exacerbate insulin resistance and negatively impact the overall prognosis of the disease. Objective: The primary goal of this study was to conduct a comparative analysis between diabetic and non-diabetic individuals regarding sleep quality, OSA risk, and obesity prevalence. Additionally, the research aimed to investigate whether these clinical factors correlated with differences in specific biomarkers, specifically melatonin and C-reactive protein (CRP) levels. Methods: A cross-sectional study was conducted at Ngoerah General Hospital involving 52 participants that fulfilled the eligibility criteria (26 with T2DM and 26 without). Sleep assessment was using the PSQI, Epworth Sleepiness Scale, and STOP-BANG questionnaire. Anthropometric measurements were taken, and blood samples were analysed for melatonin and CRP levels using ELISA. Results: In a cohort of 52 participants (divided evenly into 26 with T2DM and 26 without), significant clinical disparities were observed. The diabetic group demonstrated a much higher prevalence of poor sleep quality (61.5%) compared to the non-diabetic group (26.9%, p=0.012). Similarly, the risk of high-grade OSA was substantially more common among diabetic patients (42.3%) than in the control group (7.7%, p=0.004), with obesity present exclusively in the diabetic cohort (19.2%). Despite these findings, there were no statistically significant differences between the two groups regarding daytime sleepiness, CRP levels (p=0.634), or melatonin concentrations (p=0.194). Conclusion: Patients with T2DM exhibit a significantly higher burden of sleep dysfunction, obesity, and OSA risk compared to individuals without diabetes. However, these physical manifestations did not translate into distinct variations in CRP or melatonin levels in this study. These results highlight the necessity for a holistic approach to diabetes management that actively integrates sleep and circadian health, while suggesting that further longitudinal research is needed to clarify the behavior of these biomarkers over time.
Co-Authors Ariyanti Putri, Putu Dian I Ketut Sumada, I Ketut I WAYAN WIDYANTARA Indrasari Utami, Desak Ketut Lavenia, I Gusti Agung Ayu Gita MADE RATNA SARASWATI . Putri, Dian Kusumastuti Anggraeni Trisnawati, Sri Yenni Wiratmi, Ni Ketut Candra Yuliani, Desie Yustiantara, Putu Sanna