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All Journal Media Kedokteran Hewan
Akanbi, Olatunde Babatunde
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Medicine & Pharmacology Veterinary

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Hematological and Serum Chemistry of Canine Parvoviral Enteritis in Diverse Breeds of Dogs Olaifa, Olanrewaju Samuel; Kolawole , Aderonke Rachel; Akanbi, Olatunde Babatunde; Odita, Christiana Ibironke; Taiwo, Victor
Media Kedokteran Hewan Vol. 36 No. 1 (2025): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v36i1.2025.21-29

Abstract

Canine Parvovirus enteritis (CPV-2) is a highly infectious viral disease occurring in puppies resulting in high mortality with a myriad of clinical signs, hematological and biochemical changes during the progression of the disease. This study investigated hematological and biochemical changes in 30 CPV-positive dogs in Ibadan, Nigeria. Severe non-regenerative anemia (35.71%) and leukopenia (22 cases) were prevalent. Thrombocytopenia was severe in 73.33% of cases. Further analysis revealed normocytic hypochromic anemia in 42.86%, microcytic hypochromic anemia in 28.57%, and leukopenia categorized as mild (5), moderate (12), or severe (5). Biochemical changes included hyperproteinemia (26.7%), hyperalbuminemia, hyperglobulinemia, and elevated liver enzymes in some cases. Renal dysfunction was evident in 16.7% of dogs with elevated creatinine. Significant differences (p<0.05) were observed between infected and healthy dogs. These findings underscore the critical impact of CPV on hematological and biochemical profiles, necessitating supportive care and emphasizing the crucial role of vaccination in disease prevention.
Clinical Signs and Laboratory Markers Compete Favorably with Antigen Detection of Canine Parvovirus-2 in Dogs Akanbi, Olatunde Babatunde; Fagbohun , Olusegun; Kolawole , Aderonke Rachael; Olaifa , Olanrewaju Samuel; Aliyu, Victor; Ekong, Pius Stephen; Daodu, Oluwafemi Babatunde; Olopade, James Olukayode; Taiwo, Victor Olusegun
Media Kedokteran Hewan Vol. 36 No. 2 (2025): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v36i2.2025.110-122

Abstract

Thirty dogs (< 1 year) which reported to the Veterinary Teaching Hospital, State Veterinary Hospital and City Veterinary clinic, Ibadan between October 2023 and February 2024 and had clinical signs of depression, vomiting, diarrhea, anorexia, and fever were tested for canine parvovirus-2 by rapid antigen test and confirmed by PCR. Clinical signs (CS) presumptively diagnosed and CPV positive antigen tested dogs were recruited. A 13.33% infectivity rate was recorded in 4-weekolds and 20% in adult dogs between 7 and 12 months of age contrary to belief   of parvoviral enteritis in dogs above 6 weeks. A combination of clinical signs in 28 of 30 dogs, 93.3% (95% CI: 77.9-98.2%, p ≤ 0.9918), were positive for CPV-2, and laboratory markers (LM) including leukopenia seen in 90% of CPV infected and thrombocytopenia observed in 100% of CPV infected dogs (95% CI: 88.4 - 100.0%, p ≤ 1.000) were confirmed positive for CPE, against 100.0% antigen detection (95% CI: 88.4 - 100.0%, p ≤ 1.000) in CPV infected. Therefore, the Clinical Signs and Laboratory Markers (CSLM) method for diagnosing CPE competes favorably with rapid antigen detection of Canine Parvovirus-2. The CSLM method can be explored as an alternate diagnostic tool in resource limited environments.
TRAUMATIC VENTRICULITIS IN AN AFRICAN OSTRICH: A CASE REPORT Adam, Mohammed; Ajadi, Abdullateef Abiodun; Atata, Jamila Abiodun; Akanbi, Olatunde Babatunde
Media Kedokteran Hewan Vol. 33 No. 1 (2022): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v33i1.2022.48-52

Abstract

Traumatic ventriculitis or hardware disease is the gizzard perforation by sharp foreign bodies (metallic or sharp object) that leads to ulcerative lesions.The present Case Report was to investigate through post mortem examination the cause of African ostrich death. Necropsy was conducted on a dead male adult African Ostrich presented to the postmortem unit of the Department of Veterinary Pathology, University of Ilorin, Ilorin, Nigeria. The gross lesions showed multifocal ecchymotic and petechial haemorrhages and lacerations on the left shank and thigh as well as the cloaca and vent of the bird. A perforation of the proventriculus with adhesion of a pointed nail-like metallic sharp object of 9.4 cm in length was observed. Histopathological findings revealed obliteration of tubular and vascular congestion which predisposed the animal to metabolic disorder.
Comparative Pathologic, Immunohistochemical, Ultrastructural and Molecular study of Bovine Papilloma Virus type 1 E5 Oncogene infection in Exotic and Indigenous cattle breeds Akanbi, Olatunde Babatunde; Teifke, Jens Peter; Adedeji, Adeyinka Jeremy; Franzke, Kati; Meseko, Clement Adebajo; Daodu, Oluwafemi B.; Jegede, Henry Olanrewaju
Media Kedokteran Hewan Vol. 33 No. 2 (2022): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v33i2.2022.72-86

Abstract

Bovine papillomavirus (BPV) induces benign tumors of cutaneous or mucosa epithelia, called papillomas or warts in cattle and generally regress without eliciting any serious clinical problems in the host, but occasionally persist and provide the focus for malignant transformation to squamous cell carcinoma. This has a negative implication in beef and hide industry. There is paucity of information on the comparative pathology and molecular detection of BPVs in different breeds of nomadic cattle. Consequently, 340 nomadic cattle grazing in Plateau state Nigeria were screened clinically for papillomatosis followed by histopathology. Lesion consistent with papillomatosis were further investigated using immunohistochemistry (IHC), Polymerase chain reaction (PCR) and electron microscopy. Twenty cattle (0.06%) of Friesian, Zebu, Muturu and White Fulani breeds had cutaneous papilloma and skin lesions of the head, neck, shoulders, legs, dorsum, lower abdomen and scrotum. However, only 16 (0.05%) cattle skin biopsy samples were consistent with papillomatosis histopathologically revealing varying degrees of hyperplastic epidermis with acanthosis and orthokeratotic hyperkeratosis. Nuclei in the granular layer of the epidermis were IHC positive for Bovine papillomavirus type I antigen while skin biopsy was BPV-1 E5 oncoprotein gene positive by PCR. Electron microscopy revealed ultrastructural changes consistent with Bovine papillomavirus infection. The distribution and severity of lesion varied in different breeds of nomadic cattle. The detection, diagnosis and characterization of papillomavirus in these cattle enabled the development of autogenous vaccine to immunized cattle. This study highlighted the comparative pathology and molecular characterization of BPVs in different breeds of nomadic cattle, which hitherto was lacking.
Pathology and Characterization of Fowlpox Virus Infection in a Turkey-Chicken Backyard Flock, Nigeria Akanbi, Olatunde Babatunde
Media Kedokteran Hewan Vol. 33 No. 3 (2022): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v33i3.2022.177-187

Abstract

Cutaneous scabs were seen on the nares and shanks in three grower turkeys in a mixed turkey-chicken flock in Langtang-north LGA of Plateau State, Nigeria. A chicken in the flock had diphtheritic membrane covering the mucous membranes of the oro-pharynx and the turkeys had cutaneous pox lesions on the nares and shank. Fowlpox virus infection was diagnosed by gross and histopathology and confirmed by isolation of the virus in chorioallantoic membrane of 9-12 weeks chicken embryonating eggs. The DNA of Fowl Pox Virus (FPV) was detected in the cutaneous scabs of the turkey and chicken using Polymerase Chain Reaction (PCR) which amplified a 578 base pairs fragment of the 4b core protein gene. Sequencing and phylogenetic analysis revealed that the fowlpox virus responsible for this infection clustered with the sublineage A1 genotype of clade A of fowlpox virus and shares 98% homology with the vaccine strain produced in Nigeria. The sequence has been deposited in the GenBank under the accession number MK435242. Our results confirmed the presence of FPV in the turkeys and suggest a predisposition by the chickens. We therefore suggest vaccination for small holder poultry to mitigate against mortality in turkeys and chickens and molecular epidemiology of fowlpox viruses in Nigeria to unravel viral evolution.
Escherichia Coli Infections, and Antimicrobial Resistance in Poultry Flocks, in North Central Nigeria Akanbi, Olatunde Babatunde; Olorunshola, Isaac Dayo; Osilojo, Peter; Ademola, Eunice; Agada, Godwin; Aiyedun, Julius; Odita, Christiana Ibironke; Ola-Fadunsin, Shola David
Media Kedokteran Hewan Vol. 33 No. 3 (2022): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v33i3.2022.188-207

Abstract

To investigate Eschericiacoli infections in poultry flocks, 291 tissue samples from 237 necropsied carcasses submitted from ninety-nine (99) poultry flocks in north central Nigeria were analysed. These flocks comprised layer chicken, broiler, pullet, cockerel, turkey, quail, guinea fowl and ducks. Tissue samples were pre-enriched in 10 mL buffered peptone water media and aliquots were inoculated into selective enrichment broth, sub-cultured onEosin Methylene Blue (EMB) agar and MacConkey agar (MCA) and colonies of E. coli was examined based on cultural morphological characteristics. Layer poultry and laying quails exhibited reproductive lesions which correlates with history of disruption and reduction in egg production. Antibiotics resistance rate was significant (p <0.01) with macrolide and penicillin classes been the most resistant antibiotics in layers and broiler, while quinolones and aminoglycoside were most significantly susceptible (p <0.01). Multidrug resistance (MDR) was found in 56% of the E. coli isolates, with high prevalence in younger birds.
Co-Authors Adam, Mohammed Adedeji, Adeyinka Jeremy Ademola, Eunice Agada, Godwin Aiyedun, Julius Ajadi, Abdullateef Abiodun Aliyu, Victor Atata, Jamila Abiodun Daodu, Oluwafemi B. Daodu, Oluwafemi Babatunde Ekong, Pius Stephen Fagbohun , Olusegun Franzke, Kati Jegede, Henry Olanrewaju Kolawole , Aderonke Rachael Kolawole , Aderonke Rachel Meseko, Clement Adebajo Odita, Christiana Ibironke Ola-Fadunsin, Shola David Olaifa , Olanrewaju Samuel Olaifa, Olanrewaju Samuel Olopade, James Olukayode Olorunshola, Isaac Dayo Osilojo, Peter Taiwo, Victor Taiwo, Victor Olusegun Teifke, Jens Peter