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All Journal Jurnal Kesehatan Andalas Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI)
Hakikah, Tika
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Health Professions Medicine & Pharmacology

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Peran Ki67 pada Karsinoma Nasofaring Hakikah, Tika; Rahman, Sukri; Ali, Hirowati
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 3 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v3i1.64

Abstract

Latar Belakang: Pendahuluan: Karsinoma nasofaring memiliki rekurensi atau metastasis jauh, yang menandakan suatu adanya aktifitas sel yaitu proliferasi sel. Penilaian adanya suatu proliferasi sel memerlukan biomarker, salah satunya Ki67 yang sampai saat ini sudah dikenal baik sebagai penanda proliferasi sel. Tujuan: Mengetahui peran Ki67 pada karsinoma nasofaring. Tinjauan Pustaka: Karsinoma nasofaring adalah tumor ganas sel skuamosa yang terjadi di daerah perbatasan epitel nasofaring dimana epitel kubus beralih menjadi epitel skuamosa. Pada stadium dini tidak mudah dideteksi karena secara anatomis terletak jauh di dalam kepala. Ki67 berhubungan erat dengan mitosis dan aktivitas proliferasi tumor ganas serta kinerja pengobatan kanker nasofaring. Kesimpulan: Ekspresi Ki67 yang tinggi merupakan penanda untuk prognosis buruk pada karsinoma nasofaring. ABSTRACT Background: Introduction: Nasopharyngeal carcinoma has recurrence or distant metastasis, which indicates a cell activity, namely cell proliferation. Assessment of the presence of a cell proliferation requires biomarkers, one of which is Ki67 which has been established as a marker of cell proliferation. Objective: To determine the role of Ki67 in nasopharyngeal carcinoma. Literature Review: Nasopharyngeal carcinoma is a malignant squamous cell tumor that occurs in the border area of the nasopharyngeal epithelium where the cuboidal epithelium turns into the squamous epithelium. At an early stage, it is difficult to detect because it is anatomically located deep in the head. Ki67 is closely related to the mitotic and proliferative activity of malignant tumors and the treatment performance of nasopharyngeal carcinoma. Conclusion: High Ki67 expression is a marker for poor prognosis in nasopharyngeal carcinoma.    
Sakit Kepala pada Variasi Anatomi Hidung dan Sinus Paranasal Hakikah, Tika; Irfandy, Dolly; Budiman, Bestari Jaka
Jurnal Kesehatan Andalas Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1919

Abstract

The anatomical variations of the nasal and sinus paranasal can cause headaches. The most common variants have deviated septum, concha bullosa, and agger nasi cells. These variations can cause narrowing of the osteomeatal complex. Computed tomography was the primary modality for evaluating anatomical variations of the nasal and paranasal sinuses in diagnosis and management. Functional endoscopic sinus surgery was generally performed to restore the sinuses' drainage and ventilation in anatomical variations. It has been reported a 45-year-old woman with a congested left nostril and headache that has gotten worse since 2 months ago and computed tomography of the paranasal sinuses show thickening of the bilateral maxillary sinus mucosa, bilateral anterior ethmoid, left septum deviation, concha bullous, and right inferior turbinate hypertrophy. Functional Endoscopy Sinus Surgery was performed, found anatomical variations namely, deviation septum, concha bullosa, agger nasi cells and supra agger cells. The operation gave satisfactory results. Correct evaluation of anatomical variations based on history, physical examination and investigations can assist in patient management and avoid errors during surgery. The operation gave a satisfactory result for managing symptoms on patient with anatomical variation of nasal and paranasal sinuses when compared with medicamentosa.Keywords: anatomical variations,  agger nasi cells , concha bullosa,  deviated septum, headache, supra agger cell
Diagnosis dan Tatalaksana Esofagitis Korosif Hakikah, Tika
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.33

Abstract

Introduction: Corrosive esophagitis is inflammation of the esophagus that occurs due to exposure to acidic or alkaline corrosive substances. Clinical symptoms is not always correlated with the degree of esophagus injury. The degree based on esophagoscopy findings is important in determining management and prognosis as an accurate predictor of complications to death. Objective: To know the diagnosis and management of corrosive esophagitis. Objective: To know the diagnosis and management of corrosive esophagitis. Literature Review: Corrosive esophagitis is most common in children caused by accidental ingestion, and in adults caused by suicide. Exposure to corrosive substances can be acids (sulfuric acid, hydrochloric acid), bases (potassium hydroxide, sodium hydroxide) and other substances. Esophagoscopy is an important examination to assess the degree of esophageal injury suspected of ingesting corrosive substances. Initial management according to the degree of esophageal injury can be in the form of observation, medical and surgical. Conclusion: Corrosive esophagitis occurs due to ingestion of corrosive substances that cause burns in the esophagus. Esophagoscopy is one of the useful diagnostics for assessing the degree of injury to the esophagus with the best time being carried out in the first 12-48 hours after ingestion of corrosive substances. The initial management of ingested corrosive substances is supportive care, observation and administration of medication or surgery according to the degree of injury to the esophagus.
Co-Authors Bestari Jaka Budiman Hirowati Ali, Hirowati Sukri Rahman