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All Journal Jambura Medical and Health Science Journal Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Anwar, Sarifuddin
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Utilization of Nanotechnology in Metformin Delivery: The Morphometric Study of Pancreatic Islets of Diabetic Rat Model Pakaya, David; Fahira, Aliyah Rezky; Anwar, Sarifuddin; Lintin, Gabriella Bamba Ratih
Jambura Medical and Health Science Journal Vol 3, No 2 (2024): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v3i2.24937

Abstract

Introduction: In diabetic conditions, damage of β cells and changes the structure of pancreatic islets was exhibited. Metformin can improve this condition. The nanoparticle form of metformin can improve bioavailability and accelerate cell regeneration, and pancreatic islets can be repaired. The aim of this study to know the effect of nanoparticles metformin on fasting blood glucose levels and pancreatic islet morphometry in diabetic rat models.Method: An experimental research with posttest-only controlled group design was conducted on 16 white male Wistar rats. The streptozotocin (STZ) 40 mg/kgBB were injected i.p. Rats were divided into four groups: K1: normal control; K2: negative control (diabetes model); K3: diabetes model treated with metformin 100mg/kgBB; K4: diabetes model treated with nanoparticle metformin 100mg/kgBB. The body weight and fasting blood glucose levels were measured periodically. The histology of pancreatic islets was performed with hematoxylin-eosin staining and quantified using ImageJ software. The data were analyzed with GraphPad Prism 8.0.0 using nonparametric Kruskal-Wallis test.Results: Metformin therapy decreased the fasting blood glucose levels in K3 starting on day 21 and K4 starting on day 7, but there was no statistical difference (p=0.0597). Pancreatic islet morphometry showed the pancreatic islet area was found to be statistically different (p=0.026), and the perimeter was not statistically different (p=0.115).Conclusion: Metformin nanoparticle form decreased the fasting blood glucose levels and effectively improved the area and perimeter of pancreatic islets of the diabetic rats model, but the perimeter of the pancreatic islets is not statistically significant.Keywords: Diabetes, metformin, nanoparticles, pancreatic islets, morphometry.
RASIO MONOSIT LIMFOSIT PADA PASIEN COVID-19 Harun, Haerani; Saptawinata, Aji; Towidjojo, Vera Diana; Anwar, Sarifuddin
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 1 (2024): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i1.1263

Abstract

Latar belakang : Savere acute respiartory syndrome-corona virus 2 (SARS-CoV2) merupakan virus yang memiliki gejala sama seperti SARS dan MERS yang dapat menyerang manusia dengan melibatkan sistem kekebalan tubuh (Limfosit T, Limfosit B dan Monosit), sehingga perlu dilakukan analisis Rasio Monosit Limfosit yang memiliki nilai prognostik dalam menentukan kasus yang parah. Tujuan : Tujuan penelitian ini adalah untuk membandingkan Rasio Monosit Limfosit pada pasien COVID-19 PCR Positif dan PCR Negatif. Metode : Penelitian ini menggunakan desain penelitian Observasional analitik yang mengambil data sekunder, subjek pada penelitian ialah pasien suspek COVID-19 yang selanjutnya dibagi dalam 2 kelompok (PCR Positif dan PCR Negatif) dengan jumlah responden 30 orang dalam 1 kelompok. Hasil : Hasil penelitian didapatkan hitung jenis monosit lebih rendah pada pada kelompok PCR Positif dibandingkan PCR Negatif (p<0,03) dan terdapat peningkatan bermakna MLR (p=0,005) pada kelompok PCR Positif diabndingkan PCR Negatif. MLR pada kelompok PCR positif lebih tinggi dibandingkan kelompok PCR negatif
Co-Authors David Pakaya Fahira, Aliyah Rezky Gabriella Bamba Ratih Lintin Haerani harun Saptawinata, Aji Vera Diana Towidjojo