Article Per Year (5 Year)
p-Index From 2021 - 2026
0.659
P-Index
This Author published in this journals
All Journal Majalah Obat Tradisional International Journal of Agriculture System
Uroko, Robert Ikechukwu
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Health Professions Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Assessment of Hepatoprotective and Antioxidant Effect of Acioa barteri Extract (ABE) in Alloxan-Induced Diabetic Rats Uroko, Robert Ikechukwu; Ogbonna, Henry Nnaemeka; Aguwamba, Chinedu; Nweje-Anyalowu, Paul Chukwuemeka; Umezurike, Benedict Chidozie
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88682

Abstract

This study aimed to investigate the effects of Acioa barteri extract (ABE) on hepatocellular enzyme activity, hepatic function, and antioxidant stress indices in diabetic rats induced with alloxan. The antidiabetic effect of ABE was evaluated in six experimental groups: normal controls, diabetics untreated, diabetics treated with 200mg/kg, 400mg/kg, or 800 mg/kg ABE, and diabetics treated with 3 mg/kg Glibenclamide. ABE was orally administered to induce diabetes, and alloxan-monohydrate was intraperitoneally administered. Diabetic untreated rats exhibited significantly elevated levels of alkaline phosphatase, aspartate, and alanine transaminase activities, as well as higher concentrations of total bilirubin, conjugated bilirubin, and malondialdehyde. They also showed decreased levels of total protein, albumin, globulin, and protein-bound iodine, along with reduced antioxidant enzyme activity. In contrast, diabetic rats administered ABE demonstrated reduced hepatocellular enzyme activity and improved hepatic function. These rats exhibited increased levels of total protein, globulin, and albumin, as well as higher levels of glutathione, superoxide dismutase, glutathione peroxidase, and catalase activities, compared to diabetic untreated rats. The findings suggest that ABE may help prevent oxidative stress and improve hepatic functions in diabetic rats. ABE treatment led to decreased hepatocellular enzyme activity and improved hepatic function, along with increased antioxidant enzyme activities. These results highlight the potential of ABE as a therapeutic option for diabetes-induced liver dysfunction. Further research is warranted to explore its mechanisms of action and potential clinical applications.
Influence of Palm Oil Mill Effluents on Selected Soil Physicochemical Properties and Soil Enzyme Activities Uroko, Robert Ikechukwu; Aaron, Chinomso Friday; Uche, Mercylyn Ezinne; Aguwamba, Chinedu; Nweje-Anyalowu, Paul Chukwuemaka
International Journal of Agriculture System VOLUME 13 ISSUE 1, JUNE 2025
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Palm oil mill effluent (POME) is applied on cultivated farmlands at various stages by many farmers in southeastern Nigeria with many reporting that it helps to improve crop yield and productivity despite no availability of data to support their claims. This study was therefore designed to investigate the impact of POME on soil physicochemical parameters and soil enzyme activities in soil samples from POME irrigated farmlands. In this study, top and subsoil samples from control farmland unirrigated with POME, dumpsites and 10 m away from POME dumpsites in six different farmlands irrigated with POME labelled A – F were investigated using standard analytical procedures. The results of physicochemical properties of the soils including nitrogen, phosphorus, organic carbon, organic matter, cation exchange capacity and exchangeable cations indicated significant (P<0.05) in topsoil and sub-soils containing POME when compared with their corresponding control1 soils. The lipase activities of topsoil from dumpsites A-E and subsoil 10m away from dumpsite C indicated a significant increase (P<0.05) relative to the corresponding control soils. The effluents caused a significant (P<0.05) decrease in the dehydrogenase and catalase activities of top-soils and sub-soils from each of the dumpsites and 10m away from respective dumpsites when compared with their respective control soils. The findings of this study revealed that the application of POME on soil increases the contents of soil organic carbon, organic matter, exchangeable cations, and cation exchange capacity interfere with enzyme activities.
Evaluation of Antidiabetic Properties of a Polyherbal Extract (ACCBN) on Alloxan-induced Diabetic Rats Uroko, Robert Ikechukwu; Chike-Ekwughe, Amarachi; Nweje-Anyalowu, Paul Chukwuemeka; Aguwamba, Chinedu
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99354

Abstract

Diabetes mellitus emanates from a dysfunctional metabolic process and it affects human population globally, and causes a decline in the quality of life and increase in mortality rate due to its complications and adverse effects of the available antidiabetic drugs, thus, there is a need for a better antidiabetic agent. This study assessed the antidiabetic properties of a polyherbal extract (ACCBN) on alloxan-induced diabetic rats to validate its antidiabetic claims in traditional medicine. The diabetic study had 6 groups including normal control, diabetic rats deprived of treatment, diabetic rats administered 5 mg/kg Glibenclamide, and diabetic rats administered 400 and 800 mg/kg ACCBN-extract accordingly and normal rats administered 800 mg/kg ACCBN-extract only. The rats were successfully made diabetic by the administration of alloxan monohydrate intraperitoneally whereas and the rats were treated with either Glibenclamide or ACCBN-extract orally for 28 consecutive days. The acute study of ACCBN-extract indicated lethal dose above 5000 mg/kg. The diabetic rats deprived of treatment showed significantly elevated acute and sub-acute blood glucose levels including significantly elevated glycated haemoglobin concentration and significant decline in the C-peptide and insulin levels relative to the normal control. Diabetic rats administered ACCBN-extract displayed a marked decline in the acute and sub-acute blood glucose levels in comparison to the diabetic rats deprived of treatment. The diabetic rats administered ACCBN-extract displayed a remarkable decline in glycated haemoglobin level and significantly elevated C-peptide and insulin concentrations compared to the diabetic rats deprived of treatment. The outcome revealed that ACCBN-extract possesses sufficient antidiabetic properties and could be effective in the management of diabetes.
Co-Authors Aaron, Chinomso Friday Aguwamba, Chinedu Chike-Ekwughe, Amarachi Nweje-anyalowu, Paul Chukwuemaka Nweje-Anyalowu, Paul Chukwuemeka Ogbonna, Henry Nnaemeka Uche, Mercylyn Ezinne Umezurike, Benedict Chidozie