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All Journal Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional
Ogbonna, Henry Nnaemeka
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Assessment of Hepatoprotective and Antioxidant Effect of Acioa barteri Extract (ABE) in Alloxan-Induced Diabetic Rats Uroko, Robert Ikechukwu; Ogbonna, Henry Nnaemeka; Aguwamba, Chinedu; Nweje-Anyalowu, Paul Chukwuemeka; Umezurike, Benedict Chidozie
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88682

Abstract

This study aimed to investigate the effects of Acioa barteri extract (ABE) on hepatocellular enzyme activity, hepatic function, and antioxidant stress indices in diabetic rats induced with alloxan. The antidiabetic effect of ABE was evaluated in six experimental groups: normal controls, diabetics untreated, diabetics treated with 200mg/kg, 400mg/kg, or 800 mg/kg ABE, and diabetics treated with 3 mg/kg Glibenclamide. ABE was orally administered to induce diabetes, and alloxan-monohydrate was intraperitoneally administered. Diabetic untreated rats exhibited significantly elevated levels of alkaline phosphatase, aspartate, and alanine transaminase activities, as well as higher concentrations of total bilirubin, conjugated bilirubin, and malondialdehyde. They also showed decreased levels of total protein, albumin, globulin, and protein-bound iodine, along with reduced antioxidant enzyme activity. In contrast, diabetic rats administered ABE demonstrated reduced hepatocellular enzyme activity and improved hepatic function. These rats exhibited increased levels of total protein, globulin, and albumin, as well as higher levels of glutathione, superoxide dismutase, glutathione peroxidase, and catalase activities, compared to diabetic untreated rats. The findings suggest that ABE may help prevent oxidative stress and improve hepatic functions in diabetic rats. ABE treatment led to decreased hepatocellular enzyme activity and improved hepatic function, along with increased antioxidant enzyme activities. These results highlight the potential of ABE as a therapeutic option for diabetes-induced liver dysfunction. Further research is warranted to explore its mechanisms of action and potential clinical applications.
Evaluation of Selected Pharmacological Properties of a Polyherbal Extract (Aju Mbaise) in Experimental Rats Uroko, Robert Ikechukwu; Ijioma, Nnah Solomon; Ogbonna, Henry Nnaemeka; Uchenna, Nancy Oluomachi
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.591-599

Abstract

Aju Mbaise, an herbal combination widely utilized in southeastern Nigeria for managing postpartum complications and alleviating menstrual pain, was evaluated for analgesic, anti-inflammatory, and anti-diarrheal properties in rats. Specific objectives included evaluating anti-diarrheal effects, examining anti-inflammatory effects and assessing analgesic properties of the herbal combination. The study involved subjecting the Aju Mbaise polyherbal extract (APE) to phytochemical analysis and acute toxicity testing. Anti-diarrheal effects were evaluated by administering charcoal as a meal and using castor oil-induced models. Anti-inflammatory effects were assessed through the carrageenan-induced paw oedema model, and analgesic properties were examined using the acetic acid-induced pain model. Phytochemical analysis identified alkaloids, tannins, phenols, steroids, cardiac glycosides, terpenoids, flavonoids, and saponins in the extract. The acute toxicity value exceeded 5000 mg/kg body weight, indicating safety. In animal studies, APE exhibited significant inhibitory effects on intestinal motility, reduced wet stool frequency, and influenced the castor oil-induced diarrhoea and enhanced anti-inflammatory activities. Additionally, it demonstrated a reduction in acetic acid-induced pain in rats. The APE with its diverse phytochemical composition, possesses anti-diarrheal, anti-inflammatory, and analgesic properties. However, further research is needed to establish ideal dosages and potential adverse effects.
Co-Authors Aguwamba, Chinedu Ijioma, Nnah Solomon Nweje-Anyalowu, Paul Chukwuemeka Uchenna, Nancy Oluomachi Umezurike, Benedict Chidozie Uroko, Robert Ikechukwu