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Exploring Systemic Lupus Erythematosus Pathogenesis through Animal Models: A Systematic Review of Humanized and Pristane-Induced Lupus Mice Airlangga, Dimas Ikhsan; Rahmawati, Hanifa Rizky; Susianti, Hani; Handono, Kusworini
Journal of Biomedicine and Translational Research Vol 9, No 3 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i3.19434

Abstract

Studies involving experimental animals to explore the pathogenesis of systemic lupus erythematosus (SLE) which leads to the selection of optimal therapy have been widely conducted. The well-known model used to study SLE includes the pristane-induced mouse model and the more recently developed humanized mouse model that implants human immune cells into immunodeficient mice. The current state of the research has yet to provide a systematic review that analyzes both model and its contribution to our understanding of SLE pathogenesis. This systematic review-based study aims to provide a comprehensive overview of the development and application of pristane-induced and humanized mouse models. We obtained several relevant article sources include: (1) Search Strategy, on databases such as PubMed, MEDLINE, ScienceDirect, and Cochrane by adjusting the protocols listed in the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA); (2) Eligibility based on exclusion and inclusion criteria; and (3) Data Extraction. The findings show that 30 articles are relevant to the subject matter. Several strains of mice were used in the model of the 0.5 pristane injection method and the humanized mice model. All studies showed similar patterns in the onset and manifestation of SLE in mice models with slight variations. The purpose of using the pristane injection method and humanized mice model is adjusted to the output of each study. A variety of research preferences can be used as a reason for choosing pristane and humanized cells transplanted SLE methods in making lupus model mice.
Pembentukan kelas kesehatan reproduksi, mental, dan nutrisi sebagai persiapan menghadapi masa menopause bagi wanita pra-lansia di PKK RT 24/RW 05 Kel. Syamsudin Noor, Kota Banjarbaru Sanyoto, Didik Dwi; Triawanti, Triawanti; Limantara, Sherly; Juhairina, Juhairina; Setiawan, Bambang; Qomariah, Nur; Dafif, Muhammad Welly; Habibah, Adelia Umi; Zeta, Metria; Airlangga, Dimas Ikhsan; Rahmadayanti, Tyas Ningrum
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 6 (2025): November (In Progress)
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i6.34667

Abstract

Abstrak Menopause merupakan fase transisi biologis pada wanita yang ditandai dengan penurunan hormon estrogen dan dapat menimbulkan masalah kesehatan seperti osteoporosis, gangguan metabolisme, penyakit kardiovaskular, serta gangguan psikologis. Kelompok PKK RT 24/RW 05 menghadapi kurangnya pengetahuan tentang gejala pra-menopause serta cara mengelola perubahan fisik dan emosional. Program pengabdian masyarakat ini bertujuan meningkatkan pemahaman wanita pra-lansia mengenai kesehatan reproduksi, mental, dan gizi sebagai persiapan menghadapi menopause. Kegiatan dilaksanakan di PKK RT 24/RW 05 Kelurahan Syamsudin Noor, Kota Banjarbaru, dengan peserta sebanyak 29 orang berusia 33–63 tahun. Metode pelaksanaan meliputi persiapan, penyuluhan, diskusi interaktif, serta evaluasi melalui pre-test dan post-test. Hasil kegiatan menunjukkan adanya peningkatan signifikan pada pengetahuan peserta, dengan rata-rata nilai pre-test 77,76 meningkat menjadi 90,00 pada post-test. Selain itu, seluruh peserta menyatakan kegiatan bermanfaat dan berharap agar kegiatan serupa dilaksanakan kembali. Program pengabdian masyarakat mengenai edukasi kesehatan reproduksi, mental, dan gizi bagi wanita pra-lansia di PKK RT 24/RW 05 Kelurahan Syamsudin Noor terbukti efektif meningkatkan pengetahuan dan pemahaman peserta dalam menghadapi masa transisi menopause. Kata kunci: menopause; kelas kesehatan; pra-lansia. AbstractMenopause is a biological transition phase in women characterized by decreased estrogen levels. It can cause health problems such as osteoporosis, metabolic disorders, cardiovascular disease, and psychological disorders. The PKK RT 24/RW 05 group lacks knowledge about premenopausal symptoms and how to manage physical and emotional changes. This community service program aims to improve pre-elderly women's understanding of reproductive, mental, and nutritional health in preparation for menopause. The program took place at the PKK RT 24/RW 05 in Syamsudin Noor Urban Village in the city of Banjarbaru, with 29 participants ranging in age from 33 to 63. Implementation methods included preparation, counseling, interactive discussions, and evaluation through pre- and post-tests. Results showed a significant increase in participants' knowledge, with average pre-test scores increasing from 77.76 to 90.00. Additionally, all participants stated that the program was useful and expressed interest in similar programs in the future. This community service program on reproductive, mental, and nutritional health education for pre-elderly women in PKK RT 24/RW 05, Syamsudin Noor Urban Village, was effective in increasing participants' knowledge and understanding of the menopause transition period. Keywords: menopause; health class; pre-elderly.