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All Journal Jurnal Teknologi Informasi dan Ilmu Komputer Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Folia Medica Indonesiana
Syahrul Chilmi, Syahrul
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Engineering Health Professions Medicine & Pharmacology Neuroscience Public Health

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Kombinasi Elektroporasi dan Aspirin Menghambat Aktivasi Nuclear Factor Kappa B (NFkB) pada Kultur Sel Mononuklear Darah Tepi Pasien Leukemia Akut Aulya, Zuly Vita; Arthamin, Maimun Z; Chilmi, Syahrul; Widodo, Moch. Aris; Sujuti, Hidayat
Majalah Kesehatan FKUB Vol 1, No 1 (2014)
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.602 KB)

Abstract

Leukemia akut (LA) adalah keganasan klonal akibat mutasi gen somatik pada progenitor sel hematopoietik. Mutasi ini menyebabkan pertumbuhan sel hematopoietik berhenti. Penangganan LA saat ini masih menggunakan protokol kemoterapi standar dengan angka kekambuhan yang tinggi sehingga diperlukan peningkatan dosis yang secara tidak langsung meningkatkan efek samping. Penelitian ini bertujuan untuk mengetahui efektifitas dan efisiensi kombinasi antara elektroporasi dan aspirin pada kultur sel mononuklear darah tepi pasien LA. Penelitian ini adalah studi eksperimental menggunakan randomized post test only controlled group design. Sampel penelitian adalah isolat sel mononuklear darah tepi (PBMC) pasien LA yang diambil dari lab PK RSSA dengan studi ex vivo yang dibagi dalam 4 kelompok dengan pemberian paparan listrik sebesar 200 Hz selama 5 detik dan aspirin dalam tiga variasi dosis (PA1 = 2,5 mmol ; PA2 = 5 mmol ; PA3 = 10 mmol). Ekspresi NFkB diidentifikasi dengan metode imunositokimia. Data yang diperoleh dianalisis dengan uji analysis of varian (ANOVA). Adanya perbedaan ekspresi NFkB pada keempat kelompok tersebut diuji dengan post hoc multiple comparison test. Penelitian ini  menunjukkan bahwa pada kelompok PA3 ekspresi NFkB menurun paling tinggi dibandingkan dengan kelompok  PA1 dan PA2. Penelitian ini menyimpulkan bahwa kombinasi elektroporasi  dan aspirin  dapat meningkatkan jumlah kultur sel mononuklear darah tepi pasien leukemia akut yang mengalami apoptosis setelah diberikan perlakuan dengan melihat penurunan ekspresi NFkB secara signifikan. Kata kunci: Apoptosis, Aspirin, Leukemia akut (LA), Listrik pulsasi, NFkB. 
Exploring How Albumin Supplementation Affects Serum Albumin Levels, CD8+ Lymphocyte Counts, and Interferon Gamma In Rifampicin-Resistant TB Patients Yusdianto, Adrian; Chozin, Iin Noor; Sartono, Teguh Rahayu; Tantular, Rezki; Chilmi, Syahrul; Setijowati, Nanik
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.874

Abstract

Background: Drug-resistant tuberculosis (DR-TB) remains a global health threat, with increasing cases unresponsive to rifampicin therapy. Diagnosing rifampicin-resistant TB (RR-TB) requires a multidisciplinary approach, in which markers such as interferon-gamma (IFN-ɣ) are useful for diagnosis, monitoring, therapy evaluation, and prognosis. Hypoalbuminemia commonly accompanies TB patients, evidenced by weight loss and reduced serum albumin levels. TB infection stimulates cytokine production, which suppresses albumin synthesis and regulation, affecting both prognosis and treatment success, particularly in RR-TB. This study aimed to evaluate the role of albumin supplementation in improving serum albumin levels, CD8+ lymphocyte counts, and IFN-ɣ levels in RR-TB patients. Methods: This true experimental study with a pre- and post-test control group design was conducted at Saiful Anwar Hospital. Thirty subjects were recruited: 10 healthy individuals (control group), 10 RR-TB patients receiving albumin supplementation (egg white extract) for 30 days (RR-TB + Albumin), and 10 RR-TB patients without supplementation (RR-TB only). Peripheral blood samples were collected before and after anti-TB drug (ATD) and albumin administration. Flow cytometry was used for analysis. Data were analyzed using SPSS and Partial Least Squares (PLS) analysis. Results: Significant differences in albumin and IFN-ɣ levels were observed between the control and RR-TB groups before supplementation. No significant differences were found in CD8+ lymphocyte counts (P=0.402) or IFN-ɣ levels (P=0.390) between supplemented and non-supplemented RR-TB patients. However, albumin levels (P=0.003) and body weight (P=0.014) increased significantly in the supplemented group. Conclusion: Albumin supplementation significantly increases serum albumin levels and body weight in RR-TB patients, but does not significantly affect CD8+ lymphocyte counts or IFN-ɣ levels.
Sistem Identifikasi Kesehatan Pencernaan Berdasar Suara Usus Menggunakan Embedded System Fabiana, Ryzaldi Ananda; Prasetio, Barlian Henryranu; Setiawan, Eko; Chilmi, Syahrul; Widasari, Edita Rosana
Jurnal Teknologi Informasi dan Ilmu Komputer Vol 10 No 2: April 2023
Publisher : Fakultas Ilmu Komputer, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25126/jtiik.20236515

Abstract

Ileus adalah salah satu penyakit usus yang disebabkan oleh tersumbatnya lumen usus akibat berhentinya gerak peristaltik di dalam usus. Jika tidak ditangani dengan cepat, Ileus bisa menyebabkan usus berlubang. Namun, penderita Ileus seringkali tidak menyadari terjadinya penyakit ini di dalam tubuhnya, sehingga sebaiknya memeriksakan kesehatan pencernaan setiap hari sebagai pencegahan. Oleh karena itu, diperlukan stetoskop digital untuk memberikan jawaban dari hasil auskultasi. Penelitian ini menggunakan stetoskop yang dimodifikasi dengan soundcard yang terhubung dengan raspberry pi dan ditampilkan melalui aplikasi VNC Viewer. Sedangkan Convolutional Neural Network dengan model tensor flow digunakan sebagai metode klasifikasi dan MFCC teknik ekstraksi fiturnya. Sistem merekam dan mendeteksi kehadiran suara perut dengan auskultasi selama 10 detik, dan jika terdeteksi suara perut lebih dari 1 maka dapat disimpulkan pencernaan itu sehat, begitu juga sebaliknya. Dalam penelitian ini, uji klasifikasi untuk yang lain diberi label ‘NIHIL’ suara perut, dan hasil auskultasi adalah 5,85 detik untuk uji klasifikasi. Akurasi yang diperoleh untuk klasifikasi TERDETEKSI' adalah 90%, dan untuk ‘NIHIL’ adalah 100%. AbstractIleus is one intestinal disease caused by the blockage of the bowel lumen due to the cessation of peristalsis within the intestine. If not handled quickly, Ileus could lead to a perforated bowel. However, the sufferer of Ileus often does not realize the occurrence of this disease within his body, so it would be better to check up on the digestive health every day as a preventive. Therefore, a digital stethoscope is needed to provide answers from auscultation results. This study used a modified stethoscope with a soundcard connected to the raspberry pi and displayed through the VNC Viewer application. Meanwhile, Convolutional Neural Network with tensor follow model is used as the classification method and MFCC Technique as the feature extraction. The system records and detects the bowel noise with auscultation for 10 seconds, and if the bowel noise is detected more than1 time, it means normal condition or health, and vice versa. In this study, the classification test for another was labeled with ‘NIHIL,' and the auscultation result was 5.85 seconds for the classification test. The accuracy obtained for the classification of 'digestion-sound' is 90%, and for the 'no digestion sound' is 100%.
Serological Profiles of Systemic Lupus Erythematosus in Humanized Mice and Pristane-Induced Lupus Models Chilmi, Syahrul; Airlangga, Dimas Ikhsan; Susianti, Hani; Handono, Kusworini
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study compared the serological markers of pristane-induced mice to humanized mouse models of lupus achieved by transplanting stem cells from lupus patients, which is a novel method in Indonesia. 2. This study will allow for more accurate research into the pathophysiology of the disease and the development of new lupus treatment strategies. Abstract More studies related to systemic lupus erythematosus (SLE) therapy are urgently needed because of the current insufficiency in treatment effectiveness. However, due to ethical limitations, researchers use experimental animals as a substitute for conducting studies on humans. Models commonly used to study lupus include the pristane-induced mouse model and the recently developed humanized mouse model. The second model involves implanting human immune cells into immunodeficient mice. This study compared the serologic profiles of lupus antibodies, the antinuclear antibodies (ANA) and anti-double stranded DNA (anti-dsDNA), in both mouse models. The aim was to determine which one is more promising for use as a lupus animal model. Thirty BALB/c mice (Mus musculus) were used as subjects and divided into three groups: K1, K2, and K3. K1 served as the control group, consisting of healthy mice that received a placebo. The K2 mice were intraperitoneally injected with 0.5 cc of pristane. The K3 mice were transplanted with stem cell cultures from SLE patients, resulting in humanized mice with immune deficiencies. The mice were observed for 16 weeks, during which the ANA and anti-dsDNA levels in their serum were obtained for analysis using the Kruskal-Wallis test (p<0.05). The comparison revealed differences in the average ANA and anti-dsDNA levels among the three groups. K3 had the highest ANA and anti-dsDNA levels, followed by K1 and K2. The Kruskal-Wallis test indicated that the differences were not significant in the mean levels of ANA (p=0.156) and anti-dsDNA (p=0.061). In conclusion, the humanized mouse model has higher ANA and anti-dsDNA antibody levels compared to the pristane-induced mouse model, albeit without a significant difference. This suggests a positive picture of the humanized mouse model of lupus, making it an invaluable tool for studying the disease and testing potential therapeutic interventions.
Co-Authors Airlangga, Dimas Ikhsan Barlian Henryranu Prasetio Chozin, Iin Noor Edita Rosana Widasari, Edita Rosana Eko Setiawan Fabiana, Ryzaldi Ananda Hani Susianti Hidayat Sujuti Kusworini Handono Maimun Z Arthamin, Maimun Z Moch. Aris Widodo, Moch. Aris Nanik Setijowati Sartono, Teguh Rahayu Tantular, Rezki Yusdianto, Adrian Zuly Vita Aulya, Zuly Vita