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All Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Ahmad Dahlan Medical Journal
Putri, Rachmagreta Perdana
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Bibliometric Analysis of Gene Research on Aging Putri, Rachmagreta Perdana; Annisa, Annisa; Tejosukmono, Ario; Yuniasih, Dewi
Ahmad Dahlan Medical Journal Vol. 5 No. 2 (2024): November 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/admj.v5i2.11996

Abstract

Aging is associated with various factors identified in the hallmark of aging. Numerous studies have been conducted to identify genes involved in the aging process, allowing for a comprehensive understanding of this phenomenon. This study aims to provide an overview of research on genes associated with the aging process. Data for this study was obtained and analyzed from the SCOPUS database covering the period from 2014 to 2024, with a focus on medicine, neuroscience, and nursing. The keywords used for the search were "gene," "longevity," and "aging." The search results were filtered to match the study's purpose and were limited to articles in English. The data obtained was analyzed using VOSviewer version 1.6.20. A total of 1,603 articles were analyzed. The highest number of publications occurred in 2021. The most frequent sources for these articles were the journals Biogerontology and The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. The United States was the leading contributor in publications (n=488), with Harvard Medical School producing the highest number (n=45). The most-cited article was by Loboda in 2016 (1,863 citations). Research on genes associated with aging has shifted from identifying genes (2017-2019) to focusing on the functions of these genes in physiological processes and other risk factors of aging. In conclusion, the aging research has evolved from focusing solely on gene identification to exploring the physiological functions and risk factors related to aging.
MiR-141-3p Relative Expression Level from FFPE Samples as Biomarker of Prostate Adenocarcinoma Carcinogenesis in Yogyakarta, Indonesia Pratiwi, Sari Eka; Wahyuningrum, Sri Nuryani; Putri, Rachmagreta Perdana; Danarto, Danarto; Heriyanto, Didik Setyo; Arfian, Nur; Haryana, Sofia Mubarika; Astuti, Indwiani
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 1 (2022): The future of diagnostic laboratory testing
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i1.2355

Abstract

Globally, prostate cancer (PCA) is the second leading cause of male cancer-associated mortality. Micro-RNAs (miRNAs) are small non-coding RNAs considered promising biomarkers for diagnosis, prognosis, and treatment options. A miR-141 expression is frequently dysregulated and influences the development and progression of PCA. This study aimed to identify miR-141 expression level as a marker to differentiate PCA from another prostate anomaly, especially in Yogyakarta. Formalin-fixed paraffin-embedded (FFPE) tissues for each three groups: benign prostatic hyperplasia/BPH, high-grade prostatic intraepithelial neoplasia/HGPIN, and PCA (n=7/group) were stored in a commercial clinical laboratory in Yogyakarta. The total RNA was extracted from FFPE sections using miRNeasy FFPE kit, followed by the quantification of miR-141-3p expression level by RT-PCR. The result showed that miR-141 relative expression level on PCA was higher than other groups and significantly different (P<0.05, Kruskal Wallis test). The mean of the miR-141 relative expression level of BPH, HGPIN, and PCA were 1.04±0.87, 6.44±7.8, and 7.06±8.83, respectively. The relative expression level of miR-141 can potentially be a prognostic biomarker in PCA and could differentiate aggressiveness in prostate anomaly, especially BPH, HGPIN, and PCA.
Co-Authors Annisa Annisa Ario Tejosukmono Didik Setyo Heriyanto H R Danarto Indwiani Astuti Nur Arfian, Nur Sari Eka Pratiwi Sofia Mubarika Haryana Sri Nuryani Wahyuningrum Yuniasih, Dewi