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Yani Abdul Ardiyanti
The the National Agency of Drug and Food Control, district of Palangkaraya, Central Kalimantan, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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Determination Of Paracetamol, Guaiphenesin, Chlorpheniramine Maleate And Phenylpropanolamine Hydrochloride In Cough And Cold Tablet Using High Performance Liquid Chromatography Ardiyanti, Yani Abdul
Journal of Food and Pharmaceutical Sciences Vol 2, No 3 (2014): J. Food Pharm. Sci (Sept-December)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (924.419 KB) | DOI: 10.14499/jfps

Abstract

The method of choice for analysis of drugs in multi-component preparations is chromatographic based technique such as high performance liquid chromatography (HPLC). A liquid chromatographic method was applied for the analysis paracetamol (PCT), guaiphenesin (GG), chlorpheniramine maleate (CTM) and phenylpropanolamine HCl (PPA) using three different system as described in the USP XXXVI/NF 31. The method depends on a separation on  reversed-phase C8, C18 and Phenyl column for analysis PCT, GG, and CTM-PPA respectively with mobile phase water-methanol-acetic acid glacial (79:20:1) for PCT, water-methanol-acetic acid glacial (60:40:1,5) for GG and methanol-water (60:40) containing 0.34 g of monobasic potassium phosphate, 0.05 g of triethylamine hydrochloride, 0.25 g of sodium lauryl sulfate, and 0.1 mL of phosphoric acid in each 100 mL for CTM-PPA. Quantitation was achieved with UV detection at 280, 276 and 214 nm respectively for PCT, GG, and CTM-PPA based on peak area. The methods were validated in terms of system suitability test, specificity, precision, accuracy, linearity, and the results were found to be satisfactory. Keywords: RP-HPLC, Paracetamol, Guaiphenesin, Chlorpheniramine maleate, Phenylpropanolamine HCl.
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