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All Journal Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran: Media Informasi Ilmu Kedokteran dan Kesehatan Neurona
Sholehuddin, Muhammad Afif
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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MANIFESTASI KLINIS DAN LUARAN INFEKSI COVID-19 DENGAN DIABETES MELLITUS Sholehuddin, Muhammad Afif; Firmansya, Muhammad Ainul Rohman; Ilahi, Nila Hapsari Rachmat; Wahyuni, Kharisma Rizqiah; Kurniati, Kurniati; Luthfiyah, Anik; Illahi, Wiwik Kurnia; Wesprimawati, Irma
Syifa'Medika Vol 12, No 2 (2022): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v12i2.3942

Abstract

Infeksi COVID-19 pada pasien dengan diabetes mellitus dikaitkan dengan manifestasi klinis yang lebih berat dan  luaran yang lebih buruk. Studi ini bertujuan untuk mengetahui manifestasi klinis dan luaran COVID-19 pada pasien diabetes mellitus di Pondok Observasi Gelora Joko Samudro, Gresik. Studi ini merupakan studi kohort terhadap pasien COVID-19 tanpa gejala/bergejala ringan dengan diabetes mellitus di Pondok Observasi Gelora Joko Samudro Gresik Agustus 2020-Maret 2021. Kelompok kontrol merupakan pasien COVID-19 tanpa komorbid dengan kesamaan jenis kelamin dan usia. Didapatkan 19 subjek sebagai kelompok diabetes. Kelompok diabetes mellitus memiliki resiko sekitar 6 kali lebih tinggi untuk mengalami gejala dibandingkan dengan kelompok kontrol (HR 6,04 IK95% 1,34-27,2). Dibandingkan dengan kelompok kontrol, kelompok diabetes juga memiliki angka konversi negatif di akhir perawatan lebih rendah (HR 0,061 IK95% 0,013-0,286), rerata durasi peluruhan kuman sekitar 5 hari lebih lama (Selisih Rerata 5,7 IK95% 3,73-7,75) dan rerata durasi rawat inap sekitar 5 hari lebih lama (Selisih Rerata 5,3 IK95% 3,07-7,46). Keterbatasan dalam jumlah sampel mempengaruhi hasil penelitian ini. Diperlukan studi dengan jumlah yang lebih besar dan mencakup pasien dengan gejala sedang/berat untuk hasil yang lebih baik. Pasien dengan diabetes mellitus memiliki manifestasi klinis dan luaran COVID-19 yang lebih buruk dibandingkan dengan pasien tanpa komorbid diabetes mellitus.
Keluaran Klinis Pasien Stroke dengan Covid-19 di RSUD Dr. Soedomo Trenggalek pada Tahun 2020 - 2021 Abdillah, Mi'rajatul; Sholehuddin, Muhammad Afif; Ikhromi, Noryanto; Subroto, Antonius Gatot
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 4 (2023): Vol 39 No 4 (2023)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i4.408

Abstract

Introduction: In Indonesia, there is still little data on stroke with COVID-19 patients. COVID-19 patients also experience stroke. This study aims to determine the clinical outcomes of stroke with COVID-19 patients in Trenggalek, Indonesia. Methods: This study used a cross-sectional study design by comparing the clinical outcomes of stroke patients with COVID-19 and stroke patients without COVID-19 at RSUD Trenggalek. The independent variable studied in this study was COVID-19 infection status based on medical records. The study group was subjects with stroke and COVID-19 infection. The control group is subjects with stoke without COVID-19 infection. The dependent variables studied in this study were length of hospitalization, cost of care, and mortality rate. Results: This study found that the average age of patients stroke with COVID-19 was 65 years. Stroke patients with COVID-19 have a higher mortality rate than stroke patients without COVID-19 (p<0.001; 95% CI). The average cost of care in the group of stroke patients with COVID-19 was significantly higher than the stroke group without COVID-19 (p<0.001; CI 95%). However, there was no statistically significant difference in the length of treatment between the control group and the intervention group. (p=0,326). Conclusion: Stroke patients with COVID-19 have higher mortality rates and treatment costs than those without COVID-19. Old age has a higher risk of being infected with the COVID-19 type. However, no significant difference was found in the length of treatment.
CLINICAL MANIFESTATIONS AND OUTCOMES OF COVID-19 IN THE ELDERLY GROUP: OBSERVATIVE COHORT STUDY Sholehuddin, Muhammad Afif; Rohman Firmansya, Muhammad Ainul; Rachmat Ilahi, Nila Hapsari; Wahyuni, Kharisma Rizqiah; Kurniati, Kurniati; Ilahi, Wiwik Kurnia; Wesprimawati, Irma; Luthfiyah, Anik
JURNAL KEDOKTERAN Vol. 7 No. 2 (2022): Juli 2022
Publisher : Fakultas Kedokteran Universitas Islam Al-Azhar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36679/kedokteran.v7i2.468

Abstract

Indonesia has the 4th largest number of elderly population in the world. Recent studies, had shown that elderly population was associated by higher risk for developing severe infection and worse outcome compared to general population. While growing number of evidence support those finding, few local study had shown similar result. This study was aimed to describe clinical manifestation and outcome of COVID-19 in elderly population. This Observational Cohort studies was conducted on subject admitted on Gelora Joko Samudro observation hut, Gresik for COVID-19 with mild or no symptoms (based on clinical symptom classification of COVID-19 infection of Indonesian Ministry for Health, 5th Revision July 2020) and age over 60 years old. Subjects aged 20-59 were enrolled as paired control group. From total 1238 patient, there are 24 (1.94%) subjects aged more than 60. Majority of the subject were male (75%), with average age 64.7±4.78 years old. Compared to the control group, elderly had lower incidence of symptomatic infection (HR 0.4 CI95% 0.16-0.77), lower incidence of negative conversion (HR 0.1 CI95% 0.03-0.30), longer duration of viral shedding (MD 3.8 CI95% 1.73-5.77) and longer day of inpatient (MD 4.1 CI95% 2.56-5.61). In conclusion, elderly population had lower incidence of symptomatic infection but had worse clinical outcome in negative conversion, duration of viral shedding and day of hospitalization. Keywords: Elderly; COVID-19; Clinical Manifestation; Clinical Outcome.
Co-Authors Abdillah, Mi'rajatul Firmansya, Muhammad Ainul Rohman Ikhromi, Noryanto Ilahi, Nila Hapsari Rachmat Ilahi, Wiwik Kurnia Illahi, Wiwik Kurnia Kurniati Kurniati Luthfiyah, Anik Rachmat Ilahi, Nila Hapsari Rohman Firmansya, Muhammad Ainul Subroto, Antonius Gatot Wahyuni, Kharisma Rizqiah Wesprimawati, Irma