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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Rahmad Isnanta
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Perbandingan akurasi diagnostik kriteria cornell product dengan kriteria sokolow lyon dalam menentukan hipertrofi ventrikel kiri pada pasien hipertensi obese di RSUP H. Adam Malik, Medan Muhammad Azhari; Rahmad Isnanta; Zainal Safri; Refli Hasan
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 2 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Introduction : LVH is an important cardiovascular risk factors in hypertensive patients.Accuracy of ECG criterias was relatively low in diagnosis LVH. Cornell product criteria are the criteria used in the diagnosis LVH in obesity because of easier application. The aim of this study was Determine the accuracy of the Cornell product and sokolow lyon in the detection of left ventricular hypertrophy in obese hypertensive patients at Adam Malik General Hospital.Methods : This cross sectional study from September to October 2015 on 61 cardiology policlinic patients and we did anamnesis, measurement of blood pressure, height, body weight, BMI, BSA, ECG and Echocardiography.Result : From61 patients admitted to cardiology policlinic, we found 34 male and 27 female. The result of echocardiography revealed 38 of hypertensive patients have LVH (62.3%). Sensitivity, specifity and accuracy of different ECG criteria for diagnosis LVH ranged from 31.6% (Cornell product and Romhilt estes) to 47.4% (Cornell Voltage), 65.2%(Cornell Voltage) to 95.8%(Sokolow Lyon), 50% (Cornell Product and Romhilt Estes)to 61.7% (Sokolow Lyon). Positive predictive value were ranged from 75% (Cornell & Romhilt Estes) to 92.9% (Sokolow Lyon) andNegative predictive value were ranged from 42.2%(Cornell Product and Romhilt estes) to 46.8% (Sokolow lyon).Conclusion :The accuracy of ECG criteria Cornell Product no better than lyon Sokolow criteria in terms of assessing LV hypertrophy in hypertensive patients with obesity.Key word : Leftventricular hypertrophy, Cornel product, sokolow lyon, hypertensive obese
Correlation of Platelet Distribution Width (PDW) and Troponin I in Acute Myocardial Infarction -, Maulinda Putri; Refli Hasan; Rahmad Isnanta
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 3 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (746.674 KB) | DOI: 10.32734/jetromi.v2i3.4287

Abstract

Background. Coronary artery disease (CAD) is caused by narrowing of the coronary arteries. In the event of acute myocardial infarction (AMI), there will be an increase in heart markers. Several studies have examined the relationship between Platelet Distribution Width (PDW) and AMI, but there is no specific correlation with troponin as the most sensitive and specific cardiac biomarker for AMI. This study aims to see the correlation PDW values with troponin I in patients with AMI. Method. This study was a cross-sectional method to determine the correlation of PDW variable values ​​with troponin I in patients with AMI. In this study, the sample consisted of 64 people. Results. There is a moderate correlation between PDW and troponin I (r2= 0.72, p <0.001). There is a strong correlation with positive direction between PDW and Troponin I in patients with AMI based on the onset of chest pain (<6 hours and > 6 hours : r2 = 0.647 p <0.001and r2 = 0.756, p <0.001). Conclusion. Platelet Distribution Width (PDW) is strongly correlated with Troponin I in patients with AMI, and based on chest pain onset also has a significantly positive correlation.
Effect of Salam leaf extract (Syzygium Polyanthum) to serum IL-10 levels on Acute Coronary Syndrome in Wistar Strain Mice Model Tanjung, Yulisa Astari; Refli Hasan; Rahmad Isnanta
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 3 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.692 KB) | DOI: 10.32734/jetromi.v2i3.4296

Abstract

Background Coronary Heart Disease (CHD) is one of the leading causes of death in developed and developing countries.  Syzygium polyanthum leaf (daun salam) are reported to have anti-inflammatory, antioxidant, antidiabetic, antimicrobial, antihypertensive, antitumor, antidiarrheal, acetylcholinesterase inhibition, and lipase inhibitory activity. The purpose of this study was to prove the effect of bay leaf extract (Syzygium polyanthum) on serum interleukin (IL)-10 levels in the heart of Wistar Strain Mice Model of Acute Coronary Syndrome (ACS). Methods This is an experimental study to compare the IL-10 level in 32 ACS mice which were divided into 8 groups. Serum IL-10 values were collected and analyzed according to the corresponding group with and without bay leaf extract administration, on day 1,4,7, and 14. Result: There is an IL-10 value increasing with the duration of examination following the onset of ACS induction. The highest average IL-10 value was found on the 14th day, in the two groups. On the same day, it was seen that the treatment group had a higher IL-10 value compared to the control group (p<0.001). The result showed that the concentration of IL-10 was significantly greater among the treatment group, which  reveal the potential benefit of bay leaf extract in patients with ACS. Conclusion: There was found a significant difference of serum IL-10 between Wistar Strain Mice Model of ACS that was given S. polyanthum leaf extracts. S. polyanthum leaf extract has quite extensive benefits in the cardiovascular system.
Association of Neutrophil Lymphocyte Ratio (NLR) with Global Registry of Acute Coronary Events (GRACE) Scores in Acute Coronary Syndrome Baginda Yusuf Siregar; Refli Hasan; Rahmad Isnanta
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 3 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.978 KB) | DOI: 10.32734/jetromi.v2i3.4312

Abstract

Background. Inflammation plays an important role in the initiation of atherosclerosis from the beginning of plaque to rupture cause Acute Coronary Syndrome (ACS). Neutrophil Lymphocyte Ratio (NLR) indicator of systemic inflammation in ACS. Risk stratification was needed for assessment and selection of initial invasive strategies and find the best strategy in ACS. The Global Registry of Acute Coronary Events (GRACE) scores recommended risk stratification of ACS. Aims of the study to determine the association and cut-off value NLR with risk stratification GRACE score. Method. This study is analytical with a cross-sectional retrospective design. Data were analyzed after distribution test, then mean difference and correlation test was using the SPPS program where p <0.05 was considered statistically significant. Results. This study showed significantly higher NLR value in the high risk stratification and intermediate-risk compared to low risk stratification (7.9 ± 2.7 vs 3.6 ± 1.7; p=0.001) (5.2 ± 2.3 vs 3.6 ± 1.7; p=0.018). Significant correlation between NLR ​​with GRACE scores (r=0.570; p<0.001). Significant AUC values ​​were obtained (0.782, p <0.001, IK95% 0.674-0.89), and cut-off values NLR 4 ​​with sensitivity (78.8%) and specificity (70.3%) on the GRACE score. Conclusion. The significant association between NLR ​​with GRACE risk score in ACS.
Co-Authors -, Maulinda Putri Baginda Yusuf Siregar Hasan, Refli Nurwijayanti Tanjung, Yulisa Astari Zainal Safri