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All Journal Biology, Medicine, & Natural Product Chemistry Journal of Health Science
Kameliani, Desti
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Formulasi dan Evaluasi Sediaan Body Scrub Biji Pepaya (Carica papaya L.) Agustin, Rani Felisia; Agustin, Eriska; Kameliani, Desti
JOURNAL OF HEALTH SCIENCE Vol 3 No 2 (2025): Journal of Health Science
Publisher : LPPM Universitas Kader Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54816/jhs.v3i2.1037

Abstract

Body scrub merupakan sediaan topikal yang umum digunakan untuk mengangkat sel kulit mati melalui partikel abrasif alami. Salah satu bahan eksfoliator potensial adalah biji pepaya (Carica papaya L.), yang mengandung enzim papain dan antioksidan, serta madu sebagai humektan alami. Dalam penelitian ini, ekstrak biji pepaya diperoleh melalui metode maserasi dan diformulasikan dalam empat variasi konsentrasi (0%, 2,5%, 5%, dan 7,5%) bersama madu. Penelitian dilakukan secara eksperimental di Laboratorium Farmasi Universitas Kader Bangsa selama April–Juni 2024. Evaluasi sediaan meliputi organoleptik, homogenitas, pH, daya sebar, daya lekat, kelembapan kulit, dan iritasi. Semua formula menunjukkan stabilitas fisik yang baik. Formula F2 (5%) memberikan hasil paling optimal dengan pH stabil, daya lekat kuat, kelembapan konsisten, dan daya sebar sesuai standar. Tingkat iritasi ringan yang muncul dapat ditoleransi dan mereda dalam 48 jam. Berdasarkan hasil tersebut, formula F2 dinilai sebagai sediaan paling aman dan efektif serta berpotensi dikembangkan sebagai produk kosmetik eksfoliatif alami.
Multi-Conformation Docking and Molecular Dynamics Study of Neolignan Compounds from Ocimum sanctum L. Targeting Estrogen Receptor Alpha Fauzi, Fawwaz Muhammad; Kameliani, Desti
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.411-420

Abstract

Estrogen receptor alpha (ERalpha)-mediated breast cancer is the main target of hormone therapy. However, the long-term use of Selective Estrogen Receptor Modulators (SERMs) however, can lead to side effects and resistance. This study evaluated how well selected phenolic derivatives from Ocimum sanctum L. to various ER? conformations and to assess the initial stability of selected ligand-receptor complexes in silico. Five compounds, dominated by the neolignan group with one flavonoid derivative, were molecularly docked against four ERalpha structures representing the apo, agonist, and SERM states using AutoDock-GPU, with method validation through co-crystal ligand redocking. The binding affinity and key residue interactions were analyzed to assess cross-conformation consistency. The most stable ligand candidates were further analyzed using molecular dynamics simulations for 30 ns in the agonist and SERM conformations to evaluate the initial structural stabilities of the protein–ligand complexes. The docking results showed that most compounds had ERalpha conformation-dependent affinity; however, Tulsinol D exhibited the most consistent affinity profile and maintained interactions with key ERalpha residues across all tested conformations. Molecular dynamics simulations showed that the ERalpha–Tulsinol D complex had good initial stability, characterized by protein backbone stability, reasonable residue flexibility, maintained structural compactness, and stable ligand positioning within the binding pocket. Based on these results, Tulsinol D has potential as an in silico candidate inhibitor of ER? based on phenolic metabolites from O. sanctum and warrants further investigation through advanced computational studies and experimental validation.
Co-Authors Agustin, Rani Felisia ERISKA AGUSTIN Fawwaz Muhammad Fauzi