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Pengembangan Formula Solid Lipid Nanoparticles (SLN) Hidrokortison Asetat Garnadi Jafar; Eriska Agustin; Deny Puryani
Jurnal Pharmascience Vol 6, No 1 (2019): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i1.6080

ABSTRAK Dermatitis Atopik (DA) adalah penyakit inflamasi kulit kronis dan kambuhan, terutama pada anak-anak. Pengobatan DA salah satunya menggunakan hidrokortison. Sifat lipofil dari hidrokortison asetat (HA) akan berpengaruh terhadap penetrasinya kedalam kulit jika diberikan secara topikal. SLN (Solid Lipid Nanoparticle) merupakan sistem penghantaran obat baru yang terdiri dari matriks lipid padat dan surfaktan yang terdispersi dalam air dengan ukuran partikel 10-1000nm untuk meningkatkan solubility, stability, dan loading capacity. Metode: SLN dibuat dengan homogenisasi panas menggunakan magnetic stirrer selama 10 menit suhu 600C, dilanjutkan dengan ultraturax 5000rpm selama 10 menit dan ultrasonikasi dengan sonikator probe dengan amplitudo 55% selama 15 menit, mode pulse on-off 10 detik. Optimasi basis SLN dilakukan pada beberapa jenis lipid (GMS Cutina dan Apifil) dan surfaktan (Pluracare, Tegocare, Plantacare, dan Cremofor RH 40). Basis SLN yang terpilih adalah GMS Cutina sebagai lipid padat dengan kosentrasi 4%,5%, dan 6% dan surfaktan Pluracare 3% berdasarkan ukuran partikel terkecil, FTIR, dan DSC yang menunjukkan kompatibilitas dengan HA. Hasil: Formula SLN hidrokortison asetat yang digunakan adalah lipid padat GMS Cutina 4%-6% dan surfaktan Pluracare 3% menghasilkan ukuran partikel 806nm ± 124,67nm - 958nm ± 91,28nm, nilai PI masing-masing 0,874±0,07 - 0,943±0,15, dan nilai efisiensi penjerapan (EE) 12,5%, - 83,3%. Kata Kunci : Hidrokortison Asetat, Homogenisasi Panas, SLN (Solid Lipid Nanoparticle), Ultrasonikasi ABSTRACT Atopic dermatitis (DA) is a recurrent chronic inflammatory skin disease. Treatment of DA used one of them is hydrocortisone acetate. The lipophilic properties of hydrocortisone acetate (HA) will affect its penetration into the skin when administered topically. SLN (Solid Lipid Nanoparticle) is a new drug delivery system consisting of a solid lipid matrix and a water dispersed surfactant with a particle size of 10-1000nm to improve solubility, stability, and loading capacity. Method: SLN used hot homogenization using magnetic stirrer for 10 minutes temperature 600C, followed by ultraturax 5000rpm for 10 minutes and ultrasound with probe sonicator with 55% amplitude for 15 minutes, 10 second pulse on-off mode. Optimization of the SLN base was performed on several types of lipids (GMS Cutina and Apifil) and surfactants (Pluracare, Tegocare, Plantacare, and Cremofor RH 40). The preferred SLN base is GMS Cutina as a solid lipid with a concentration of 4%, 5%, and 6% and a 3% Pluracare as a surfactant based on the smallest particle size, FTIR, and DSC showing compatibility with HA. Result: The formula of SLN hydrocortisone acetate used GMS Cutina 4% -6% as a solid lipid and Pluracare 3% as a surfactant resulted a particle size of 806nm ± 124.67nm - 958nm ± 91.28nm, PI value of 0.874 ± 0.07 - 0.943 ± 0.15 , and the efficiency entrapment (EE) 12.5%, - 83.3%. Keywords : Hydrocortisone Acetate, Hot Homogenization, SLN (Solid Lipid Nanoparticle), Ultrasound

Formulation and Evaluation of Ketoconazole Nano-suspension Agustin, Eriska; Sari, Gita Deslia
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.9511

The use of antifungals that are widely used by the public is ketoconazole. Ketoconazole is included in the Biopharmaceutical Classification System (BCS) II category, where the drug is poorly soluble in water but has high permeability. In this study, ketoconazole was prepared in a nanosuspension formulato increase solubility. The method for preparing 2% ketoconazole nanosuspension used a sonicator bath with variations of tween 80 (F1 8%, F2 10%, F3 12%) and transcutol as surfactant and co-surfactant. The results showed that the particle size of the ketoconazole nanosuspension F1 was 102 ± 4.3 nm, F2 was 105 ± 3.2 nm, and F3 was 90 ± 2.4 nm on day 0. Testing on day 28 showed an increase in particle size in F1 115 ± 3.1 nm, F2 129±4.5nm, F3 97±2.4nm (p>0.05). In testing the morphology of the nanosuspension using Scanning Electron Microscopy (SEM), The results showed that the irregular spheres were scattered. Organoleptic testing showed clear and homogeneous preparations. pH testing for 28 days showed a pH range of 5.6-6 which is included in the physiological skin pH range (p>0.50). Nanosuspension preparations can be said to meet the physical evaluation requirements.

Formulasi dan Uji Aktivitas Antibakteri Sediaan Spray Antiseptik Tangan Non Alkohol Infusa Daun Kemangi (Ocimum basilicum L.) dan Lidah Buaya (Aloe Vera (L.) Burm.f.) Terhadap Bakteri Staphylococcus aureus ATCC 25923 Eriska Agustin; Dani Prasetyo; Nia Azzahra; Muni’ah Muchtar
JURNAL KESEHATAN TERAPAN Vol 9 No 1 (2022): Jurnal Kesehatan Terapan
Publisher : LPPM Universitas Kader Bangsa Palembang

The rapid spread of the Covid-19 virus has caused the WHO to declare the Covid-19 outbreak a global pandemic. However, public awareness of the importance of maintaining hand hygiene is still very low. The use of hand sanitizers is now increasingly widespread. Basil leaves and aloe vera have the potential to be developed as hand antiseptics because they contain secondary metabolites such as flavonoids, alkaloids, saponins and tannins. This study aims to formulate a non-alcoholic hand antiseptic spray preparation of basil and aloe vera infusion and whether it has antibacterial activity against Staphylococcus aureus ATCC 25923. Formulation of hand antiseptic spray preparation use various extract concentrations, namely F1 (20%), F2 (40%), F3 (60%), F4 (80%), and (F5 100%). Testing of antibacterial activity by agar diffusion method measuring the diameter of the inhibition zone of Staphylococcus aureus bacteria. From the results of the study, it was found that the five non-alcoholic hand antiseptic spray formulations infusion of basil and aloe vera leaves were in liquid form, had striking colors, had the same odor and were stabel for 14 days. The preparation looks homogeneous when applied to a glass object. The pH produced from this hand antiseptic spray preparation ranged from 4.5 to 6.5. The results of the antibacterial activity test showed that the inhibition of Staphylococcus aureus bacteria at F3 (60%) was 5.14 mm, F4 (80%) was 6.24 mm, and F5 (100%) was 7.26 mm which was classified as medium strength. Keywords: aloe vera, antiseptic spray, infusion, kemangi basil, Staphylococcus aureus

Standarisasi Ekstrak Kunyit Kuning (Curcuma domestica Val.) Di Desa Tanjung Batu Ogan Ilir Sumatera Selatan Trirahmi Hardiyanti; Eriska Agustin; Nia Azzahra; Purnama Purnama; Rahmad Arrajib
JURNAL KESEHATAN TERAPAN Vol 9 No 2 (2022): Jurnal Kesehatan Terapan
Publisher : LPPM Universitas Kader Bangsa Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54816/jk.v9i2.540

Penyimpanan kunyit kuning sebagai produk terstandar patut diperhatikan dan dicermati. Jika penanganan dan pengolahannya tidak benar maka mutu produk yang dihasilkan kurang berkhasiat. Standardisasi juga diperlukan agar dapat diperoleh bahan baku yang seragam yang pada akhirnya menjamin efek farmakologi tanaman tersebut. Tujuan penelitian ini untuk mengetahui standarisasi ekstrak kunyit kuning (Curcuma domestica Val.) di Desa Tanjung Batu Kabupaten Ogan Ilir Sumatera Selatan. Jenis penelitian menggunakan metode atau percobaan secara in vitro. Penelitian ini dilakukan di Laboratorium Universitas Kader Bangsa dan Laboratorium STIK Siti Kodijah Palembang yang berlangsung pada tanggal 1 Juli – 27 Juli 2020. Prosedur penelitian ini yaitu pengambilan sampel, pengolahan sampel, ekstraksi, uji fitokimia, uji flavonoid, uji tanin, uji saponin, uji alkaloid, uji stroid, dan standarisasi ekstrak parameter spesifik dan non spesifik. Hasil penelitian ini adalah hasil penentuan susut pengeringan estrak kunyit kuning sebesar 0,8726%, hasil penentuan kadar air ekstrak kunyit kuning sebesar 10%, hasil penentuan total bakteri sebanyak 19,20,28 dan penentuan total kapang sebanyak 38,103,114, hasil kadar senyawa yang larut dalam air sebanyak 4,5988% dan kadar senyawa yang larut dalam etanol sebanyak 1,6085%. Kata Kunci: Standarisasi, Ekstrak, Kunyit Kuning, Uji Parameter Spesifik dan Nonspesifik

The Evaluation of Nanoemulsion Cinnamon Extract (Cinnamomum burmanii) on Lipcream as Natural Dyes Agustin, Eriska; Agustina, Maulia
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.13842

The use of nanoemulsion in the cosmetic field has been widely developed, one of which is the use of natural dyes from natural ingredients. Nanoemulsion has the ability to provide a wider variety of colors due to its high solubilization and translucent nature. The effort to produce natural dyes can be obtained form natural resources, one of which is the cinnamon plant. Beside having a distinctive aroma, cinnamon can also produce a brownish pigment that comes form the cinnamaldehyde compound. In this study, Cinnamon extract samples were obtained by maceration method using ethanol solvent pa, cinnamon extract nanoemulsion preparations were made using a sonicator bath for 60 minutes, and lipcream preparations were made using the trituration method. The results showed that the cinnamon extract from formula F1 nanoemulsion had a particle size of 273±0.032 nm. Evaluation of the lipcream preparations carried out included organoleptics which produced a distinctive aroma of cinnamon, the resulting color was softer brown compared to conventional lipcream preparations, the texture was soft and homogeneous, the resulting pH test met the pH requirements of the lip cream, namely 4.93-5.02, adhesion 5-6 cm and 4-5 seconds of adhesion (p>0.05). The cinnamon extract nanoemulsion preparations produced particle sizes that entered the nano range and lipcream preparations produced color pigments that were softer than conventional preparations.

Evaluation of formula and antibacterial activity of spray preparation from combination of aloe vera (Aloe vera L.) and lime concentrate (Citrus aurantiifolia) as hand sanitizer Agustin, Eriska; Arsa, Arvianida Nafilah; Soyata, Amelia
Sasambo Journal of Pharmacy Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i1.513

Aloe vera plant (Aloe vera l.) has antioxidant activity and can be used as a moisturizer, especially on the inside of the leaves. Lime plant (Citrus aurantiifolia) has antibacterial activity, one of the compounds it contains is limonene. This study aims to evaluate the formula and antibacterial activity of a spray preparation combining aloe vera and lime concentrate as a Hand Sanitizer. The Hand Sanitizer spray formulation consists of four formulas with variations in the concentration of aloe vera and lime concentrate, namely F0 (0), F1 (30:20), F2 (25:25), and F3 (20:30). The evaluation carried out for 28 days includes organoleptic tests, homogeneity, pH, viscosity, drying time, and antibacterial activity. The organoleptic and homogeneity test results showed that F1, F2, and F3 were in homogeneous liquid form, cloudy orange in color, and had a distinctive lime aroma. The pH test obtained a range of 3.75-5.79. The viscosity test obtained a viscosity range of 1.06-1.29 cps. The drying time test obtained a time range of 33-46 seconds. The results of the antibacterial activity test showed that the highest inhibitory value was in formula F3 with values (14.5Â±0.2nm), followed by Formula F2 (11.5Â±0.45nm) and F1 (8.2Â±0.25nm). Based on statistical testing, it was concluded that there was an effect of each formula on antibacterial activity.

The Evaluation of Nanoemulsion Cinnamon Extract (Cinnamomum burmanii) on Lipcream as Natural Dyes Agustin, Eriska; Agustina, Maulia
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.13842

The use of nanoemulsion in the cosmetic field has been widely developed, one of which is the use of natural dyes from natural ingredients. Nanoemulsion has the ability to provide a wider variety of colors due to its high solubilization and translucent nature. The effort to produce natural dyes can be obtained form natural resources, one of which is the cinnamon plant. Beside having a distinctive aroma, cinnamon can also produce a brownish pigment that comes form the cinnamaldehyde compound. In this study, Cinnamon extract samples were obtained by maceration method using ethanol solvent pa, cinnamon extract nanoemulsion preparations were made using a sonicator bath for 60 minutes, and lipcream preparations were made using the trituration method. The results showed that the cinnamon extract from formula F1 nanoemulsion had a particle size of 273±0.032 nm. Evaluation of the lipcream preparations carried out included organoleptics which produced a distinctive aroma of cinnamon, the resulting color was softer brown compared to conventional lipcream preparations, the texture was soft and homogeneous, the resulting pH test met the pH requirements of the lip cream, namely 4.93-5.02, adhesion 5-6 cm and 4-5 seconds of adhesion (p>0.05). The cinnamon extract nanoemulsion preparations produced particle sizes that entered the nano range and lipcream preparations produced color pigments that were softer than conventional preparations.

Formulasi dan Evaluasi Sediaan Body Scrub Biji Pepaya (Carica papaya L.) Agustin, Rani Felisia; Agustin, Eriska; Kameliani, Desti
JOURNAL OF HEALTH SCIENCE Vol 3 No 2 (2025): Journal of Health Science
Publisher : LPPM Universitas Kader Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54816/jhs.v3i2.1037

Body scrub merupakan sediaan topikal yang umum digunakan untuk mengangkat sel kulit mati melalui partikel abrasif alami. Salah satu bahan eksfoliator potensial adalah biji pepaya (Carica papaya L.), yang mengandung enzim papain dan antioksidan, serta madu sebagai humektan alami. Dalam penelitian ini, ekstrak biji pepaya diperoleh melalui metode maserasi dan diformulasikan dalam empat variasi konsentrasi (0%, 2,5%, 5%, dan 7,5%) bersama madu. Penelitian dilakukan secara eksperimental di Laboratorium Farmasi Universitas Kader Bangsa selama April–Juni 2024. Evaluasi sediaan meliputi organoleptik, homogenitas, pH, daya sebar, daya lekat, kelembapan kulit, dan iritasi. Semua formula menunjukkan stabilitas fisik yang baik. Formula F2 (5%) memberikan hasil paling optimal dengan pH stabil, daya lekat kuat, kelembapan konsisten, dan daya sebar sesuai standar. Tingkat iritasi ringan yang muncul dapat ditoleransi dan mereda dalam 48 jam. Berdasarkan hasil tersebut, formula F2 dinilai sebagai sediaan paling aman dan efektif serta berpotensi dikembangkan sebagai produk kosmetik eksfoliatif alami.

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