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All Journal IPTEK The Journal for Technology and Science Journal of Civil Engineering Pharmacoscript
Endah Wahyuni
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Chemistry Computer Science & IT Medicine & Pharmacology Public Health

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POTENSI INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN GERIATRI RAWAT INAP DI SALAH SATU RUMAH SAKIT KOTA BANDUNG Robby Ramdani; Oskar Skarayadi; Wiwiek Indrawati; Endah Wahyuni; Faizal Hermanto
Pharmacoscript Vol. 5 No. 1 (2022): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v5i1.890

Abstract

Penurunan fungsi organ pada pasien usia lanjut (geriatri) akan meningkatkan resiko hipertensi sebagai salah satu penyebab komplikasi penyakit jantung,dislipidemia,diabetes melitus dan gagal ginjal. Terapi obat antihipertensi dengan komplikasi penyakit sering diberikan resep polifarmasi sehingga resiko terjadinya interaksi obat meningkat. Tujuan penelitian ini untuk mengetahui potensi interaksi obat antihipertensi pasien usia lanjut rawat inap di salah satu Rumah Sakit Kota Bandung. Metode penelitian dilakukan secara restropektif menggunakan data rekam medis pasien usia lanjut (>59 tahun) dengan diagnosa penyakit hipertensi rawat inap pada periode Januari-Desember 2020. Data dianalisis secara deskriptif menggunakan Stockley’s Drug Interaction, aplikasi drugs.com database dan Medscape Drug Interactions Checker. Hasil penelitian menunjukan bahwa sebanyak 70 pasien masuk ke dalam kriteria inklusi. Data pasien usia lanjut yang mengalami interaksi obat sebanyak 263 kejadian (97,3%). Kejadian interaksi obat dengan tingkat keparahan major sebesar 14,06%, moderate 80,46% dan minor 5,46%. Mekanisme interaksi obat secara farmakokinetika 38%, farmakodinamik 59,3%, dan tidak ada interaksi obat 2,6%. Kesimpulan penelitian ini adalah interaksi obat antihipertensi pasien usia lanjut lebih banyak terjadi pada mekanisme interaksi farmakodinamik dengan tingkat keparahan moderate.
EFFECT OF REDUCED BEAM SECTION IN STAGGERED TRUSS FRAME STRUCTURE VIERENDEEL ELEMENT WITH EARTHQUAKE LOAD ANALYSIS M. Farid Nurul Iman; Endah Wahyuni; Data Iranata
Journal of Civil Engineering Vol 32, No 2 (2017)
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (678.524 KB) | DOI: 10.12962/j20861206.v32i2.4560

Abstract

The purpose of this study is to describe the effect of Reduced Beam Section in vierendeel panel element in STF system’s inelastic behavior based on earthquake load analysis. STF system is applied to 4, 6, and 10 storey building that served as office building. The structure’s system used Special Moment Resisting Frame (SMRF) system in longitudinal direction (W-E) and STF system in transversal direction (N-S). The analysis method that used in this study is nonlinear pushover analysis. Application of RBS in vierendeel panel element showed that by the increasing of storey number, the ductility of the structure was increased in both directions, while N-S direction has bigger ductility than W-E direction. Dissipation energy of the structure was also increased, especially in N-S direction. The first yielding process occurred in vierendeel panel element, and then followed by truss and diagonal chord around vierendeel panel element, while the critical condition showed still at life safety level.
Concrete Failure Modeling Based on Micromechanical Approach Subjected to Static Loading Endah Wahyuni
IPTEK The Journal for Technology and Science Vol 21, No 1 (2010)
Publisher : IPTEK, LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j20882033.v21i1.22

Abstract

In this paper, a micromechanical model based on the Mori-Tanaka method and the spring-layer model is developed to study the stress-strain behavior of concrete. The concrete is modeled as a two-phase composite. And the failure of concrete is categorized as mortar failure and interface failure. The research presents a method for estimating the modulus of concrete under its whole loading process. The proposed micromechanical model owns the good capabilities for predicting the entire response of concrete under uniaxial compression. It is suitable that tensile strain is as the criterion of concrete failure and the prediction of crack direction also fits with experimental phenomenon.
Relationship between Static Stiffness and Modal Stiffness of Structures Endah Wahyuni; Tianjian Ji Tianjian Ji
IPTEK The Journal for Technology and Science Vol 21, No 2 (2010)
Publisher : IPTEK, LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j20882033.v21i2.36

Abstract

This paper derives the relationship between the static stiffness and modal stiffness of a structure. The static stiffness and modal stiffness are two important concepts in both structural statics and dynamics. Although both stiffnesses indicate the capacity of the structure to resist deformation, they are obtained using different methods. The former is calculated by solving the equations of equilibrium and the latter can be obtained by solving an eigenvalue problem. A mathematical relationship between the two stiffnesses was derived based on the definitions of two stiffnesses. This relationship was applicable to a linear system and the derivation of relationships does not reveal any other limitations. Verification of the relationship was given by using several examples. The relationship between the two stiffnesses demonstrated that the modal stiffness of the fundamental mode was always larger than the static stiffness of a structure if the critical point and the maximum mode value are at the same node, i.e. for simply supported beam and seven storeys building are 1.5% and 15% respectively. The relationship could be applied into real structures, where the greater the number of modes being considered, the smaller the difference between the modal stiffness and the static stiffness of a structure.
Co-Authors Data Iranata M. Farid Nurul Iman Oskar Skarayadi, Oskar Purwoko, Agus Robby Ramdani Tianjian Ji Tianjian Ji Wiwiek Indrawati