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All Journal IPTEK The Journal for Technology and Science Journal of Civil Engineering Pharmacoscript
Endah Wahyuni
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Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Engineering Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Transportation

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POTENSI INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN GERIATRI RAWAT INAP DI SALAH SATU RUMAH SAKIT KOTA BANDUNG Robby Ramdani; Oskar Skarayadi; Wiwiek Indrawati; Endah Wahyuni; Faizal Hermanto
Pharmacoscript Vol. 5 No. 1 (2022): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v5i1.890

Abstract

Penurunan fungsi organ pada pasien usia lanjut (geriatri) akan meningkatkan resiko hipertensi sebagai salah satu penyebab komplikasi penyakit jantung,dislipidemia,diabetes melitus dan gagal ginjal. Terapi obat antihipertensi dengan komplikasi penyakit sering diberikan resep polifarmasi sehingga resiko terjadinya interaksi obat meningkat. Tujuan penelitian ini untuk mengetahui potensi interaksi obat antihipertensi pasien usia lanjut rawat inap di salah satu Rumah Sakit Kota Bandung. Metode penelitian dilakukan secara restropektif menggunakan data rekam medis pasien usia lanjut (>59 tahun) dengan diagnosa penyakit hipertensi rawat inap pada periode Januari-Desember 2020. Data dianalisis secara deskriptif menggunakan Stockley’s Drug Interaction, aplikasi drugs.com database dan Medscape Drug Interactions Checker. Hasil penelitian menunjukan bahwa sebanyak 70 pasien masuk ke dalam kriteria inklusi. Data pasien usia lanjut yang mengalami interaksi obat sebanyak 263 kejadian (97,3%). Kejadian interaksi obat dengan tingkat keparahan major sebesar 14,06%, moderate 80,46% dan minor 5,46%. Mekanisme interaksi obat secara farmakokinetika 38%, farmakodinamik 59,3%, dan tidak ada interaksi obat 2,6%. Kesimpulan penelitian ini adalah interaksi obat antihipertensi pasien usia lanjut lebih banyak terjadi pada mekanisme interaksi farmakodinamik dengan tingkat keparahan moderate.
EFFECT OF REDUCED BEAM SECTION IN STAGGERED TRUSS FRAME STRUCTURE VIERENDEEL ELEMENT WITH EARTHQUAKE LOAD ANALYSIS M. Farid Nurul Iman; Endah Wahyuni; Data Iranata
Journal of Civil Engineering Vol 32, No 2 (2017)
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (678.524 KB) | DOI: 10.12962/j20861206.v32i2.4560

Abstract

The purpose of this study is to describe the effect of Reduced Beam Section in vierendeel panel element in STF system’s inelastic behavior based on earthquake load analysis. STF system is applied to 4, 6, and 10 storey building that served as office building. The structure’s system used Special Moment Resisting Frame (SMRF) system in longitudinal direction (W-E) and STF system in transversal direction (N-S). The analysis method that used in this study is nonlinear pushover analysis. Application of RBS in vierendeel panel element showed that by the increasing of storey number, the ductility of the structure was increased in both directions, while N-S direction has bigger ductility than W-E direction. Dissipation energy of the structure was also increased, especially in N-S direction. The first yielding process occurred in vierendeel panel element, and then followed by truss and diagonal chord around vierendeel panel element, while the critical condition showed still at life safety level.
Concrete Failure Modeling Based on Micromechanical Approach Subjected to Static Loading Endah Wahyuni
IPTEK The Journal for Technology and Science Vol 21, No 1 (2010)
Publisher : IPTEK, LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j20882033.v21i1.22

Abstract

In this paper, a micromechanical model based on the Mori-Tanaka method and the spring-layer model is developed to study the stress-strain behavior of concrete. The concrete is modeled as a two-phase composite. And the failure of concrete is categorized as mortar failure and interface failure. The research presents a method for estimating the modulus of concrete under its whole loading process. The proposed micromechanical model owns the good capabilities for predicting the entire response of concrete under uniaxial compression. It is suitable that tensile strain is as the criterion of concrete failure and the prediction of crack direction also fits with experimental phenomenon.
Relationship between Static Stiffness and Modal Stiffness of Structures Endah Wahyuni; Tianjian Ji Tianjian Ji
IPTEK The Journal for Technology and Science Vol 21, No 2 (2010)
Publisher : IPTEK, LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j20882033.v21i2.36

Abstract

This paper derives the relationship between the static stiffness and modal stiffness of a structure. The static stiffness and modal stiffness are two important concepts in both structural statics and dynamics. Although both stiffnesses indicate the capacity of the structure to resist deformation, they are obtained using different methods. The former is calculated by solving the equations of equilibrium and the latter can be obtained by solving an eigenvalue problem. A mathematical relationship between the two stiffnesses was derived based on the definitions of two stiffnesses. This relationship was applicable to a linear system and the derivation of relationships does not reveal any other limitations. Verification of the relationship was given by using several examples. The relationship between the two stiffnesses demonstrated that the modal stiffness of the fundamental mode was always larger than the static stiffness of a structure if the critical point and the maximum mode value are at the same node, i.e. for simply supported beam and seven storeys building are 1.5% and 15% respectively. The relationship could be applied into real structures, where the greater the number of modes being considered, the smaller the difference between the modal stiffness and the static stiffness of a structure.
CONNECTION MODEL OF CONCRETE FILLED STEEL TUBE (CFT) COLUMN TO STEEL BEAM UNDER CYCLIC Agustina D. Atmaji; Budi Suswanto; Endah Wahyuni
Journal of Civil Engineering Vol. 34 No. 1 (2019)
Publisher : Institut Teknologi Sepuluh Nopember (ITS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j20861206.v34i1.7463

Abstract

Various types of structural technology began to develop rapidly, one of which was composite steel. Composite steel (Concrete Filled Steel Tube) is a structure consisting of two or more materials with different material properties and form one unit so as to produce better combined properties. Compared to conventional steel, this column has many advantages such as convenient formwork for concrete cores provided by steel tubes, increased strength and good ductility. This study uses the CFT column as the main variable by considering variations in the CFT column on the connection using ABAQUS. Modeling was carried out with a test object of 203 × 133 × 7.8 × 5.8 mm and the CFT column dimensions of rectangular 220 × 220 × 6 mm, and circular Ø 220 mm t = 8 mm. The research method uses two steps static-general method with static-risk. The results of these two research methods have the results of approaching and having the same behavior. Modeling has fulfilled the requirements of modeling the column-beam joints that can be used in a system of earthquake-resistant reinforced steel composite concrete frame structures. Based on the modeling results that have been done, modeling has fulfilled the connection that has sufficient ductility capability.
EFFECT OF REDUCED BEAM SECTION IN STAGGERED TRUSS FRAME STRUCTURE VIERENDEEL ELEMENT WITH EARTHQUAKE LOAD ANALYSIS M. Farid Nurul Iman; Endah Wahyuni; Data Iranata
Journal of Civil Engineering Vol. 32 No. 2 (2017)
Publisher : Institut Teknologi Sepuluh Nopember (ITS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j20861206.v32i2.7507

Abstract

The purpose of this study is to describe the effect of Reduced Beam Section in vierendeel panel element in STFsystem’s inelastic behavior based on earthquake load analysis. STF system is applied to 4, 6, and 10 storey building thatserved as office building. The structure’s system used Special Moment Resisting Frame (SMRF) system in longitudinaldirection (W-E) and STF system in transversal direction (N-S). The analysis method that used in this study is nonlinearpushover analysis. Application of RBS in vierendeel panel element showed that by the increasing of storey number, theductility of the structure was increased in both directions, while N-S direction has bigger ductility than W-E direction.Dissipation energy of the structure was also increased, especially in N-S direction. The first yielding process occurred invierendeel panel element, and then followed by truss and diagonal chord around vierendeel panel element, while the criticalcondition showed still at life safety level
RELATIONSHIP BETWEEN STATIC AND DYNAMIC DISPLACEMENTS OF STRUCTURES Endah Wahyuni
Journal of Civil Engineering Vol. 30 No. 2 (2010)
Publisher : Institut Teknologi Sepuluh Nopember (ITS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j20861206.v30i2.7532

Abstract

The relationship between the static and dynamic displacements of a structure is studied and explores the application of the relationship. The key parameters are: the static stiffness of the structure, which is a measure of its resistance to an applied load; and the dynamic stiffness, which relates to a specific mode of vibration. To illustrate the salient features, two simple examples will be considered, first a beam and second a plate. These may be considered to be simple representations of a bridge and a floor respectively. The conclusions of the research are the number of modes considered increases the difference between total modal displacement and the static displacement decreases. The first mode dominated the sumof the modal displacement. It is therefore apparent that measurements of both static and dynamic stiffness can both provide useful information on the elastic behavior of a structure.
Co-Authors Agustina D. Atmaji Budi Suswanto Data Iranata M. Farid Nurul Iman Oskar Skarayadi, Oskar Purwoko, Agus Ramdani, Robby Tianjian Ji Tianjian Ji Wiwiek Indrawati