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All Journal Indonesian Journal of Pharmacology and Therapy Jurnal Kesehatan Farmasi Manajemen
Laduna Aniq
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Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Efficacy and safety of antidiabetics agents in gestational diabetes mellitus (GDM): a literature review Rommy; Aldia Dwi Karinaningrum; Berliana Luthfiananda; Laduna Aniq; Lydia Sherly Evelina; Rifani Fauzi
Indonesian Journal of Pharmacology and Therapy Vol 3 No 1 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.3244

Abstract

One of the most common metabolic diseases during pregnancy period is gestational diabetes mellitus (GDM). It is associated with several perinatal complications, especially in those who have risk factors such as obesity, polycystic ovary syndrome, and a family history of type 2 diabetes mellitus (DM). Some research has shown that physical exercise and medical nutrition treatment can give beneficial effects to control glycemic and body weight for GDM affected women. Furthermore, pharmacological agents such as insulin and a specific oral antidiabetic can be prescribed safely during pregnancy to decrease maternal glucose blood. Therapy of GDM is needed to control blood for the wellness of the patient during and after the pregnancy. The main treatment therapy for GDM is lifestyle modification, which includes medical nutritional therapy and daily physical exercise. In the special case of disorder glucose level, drug therapy will be given to the patient. Insulin is the chosen drug because it is safe and does not cross the placenta. It is the gold standard pharmacological agent for GDM treatment. However, it still has some disadvantages such as the difficulties of how to use it, how many doses must be given, and the price that tends to be expensive. Consequently, the alternative drug may have to substitute it. Insulin can be substituted by metformin and glyburide (glibenclamide) in the form of oral antidiabetic. They are equal in terms of efficacy and safety compare to insulin as a treatment for GDM. Besides, they are also cheaper, and easy to use.
GAMBARAN PENGGUNAAN OBAT ANTIHIPERTENSI DI APOTEK Laduna Aniq; Ramita Fatia Sarah
Jurnal Kesehatan Farmasi Manajemen Vol 3 No 1 (2025): JURNAL ILMU KESEHATAN FARMASI, KEPERAWATAN DAN KEBIDANAN
Publisher : JURNAL KESEHATAN FARMASI MANAJEMEN

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Abstract

Latar Belakang : Hipertensi adalah salah satu masalah kesehatan global yang prevalensinya terus meningkat dan kerap dijuluki sebagai pembunuh diam-diam karena jarang menimbulkan gejala pada tahap awal. Tujuan : Penelitian ini bertujuan untuk mengetahui gambaran penggunaan terapi antihipertensi dan menilai kesesuaiannya dengan pedoman terapi. Metode Penelitian : Rancangan penelitian ini menggunakan metode analisis deskriptif kuantitatif. Penelitian dilakukan di Apotek Nias Kota Sukabumi. Data diambil dari rekam medik dan resep secara retrospektif pada periode Januari hingga Juni 2025. Subjek penelitian adalah pasien yang terdiagnosis hipertensi yang memenuhi kriteria inklusi. Hasil : Hasil penelitian diperoleh sebanyak 72 pasien dengan hipertensi di Apotek Nias adalah berjenis kelamin perempuan (52,77%) dan laki-laki (47,22%), paling banyak berusia dewasa 18-59 tahun (76,38%), diikuti kelompok usia lanjut ≥60 tahun (23,61%). Hasil analisis menunjukkan bahwa Golongan obat antihipertensi yang paling banyak digunakan adalah golongan Calcium Channel Blocker (CCB) sebesar (61,29%), dan golongan Angiotensin II Receptor Blocker (ARB) (16,12%). Jenis obat terbanyak digunakan yaitu Amlodipin (61,28%) dan Kandesartan (13,97%). Sebagian besar pasien memperoleh terapi antihipertensi melalui pendekatan monoterapi (terapi tunggal) 82%, sedangkan 18% menggunakan kombinasi.  Pola penggunaan terapi antihipertensi di Apotek Nias masih cenderung mengikuti terapi bertahap (stepwise therapy) sesuai dengan pedoman terapi dengan pemilihan obat tunggal sebagai terapi awal.
Co-Authors Aldia Dwi Karinaningrum Berliana Luthfiananda Lydia Sherly Evelina Ramita Fatia Sarah Rifani Fauzi Rommy