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All Journal E-Jurnal Medika Udayana Indonesian Journal of Perinatology
Anwar, Meirisa Afifah Nurmalia
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Health Professions Medicine & Pharmacology Nursing

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Efek Pemberian Ketamin Sebagai Analgesia Adjuvan Pada Pasien Pasca Operasi: A Systematic Review Anwar, Meirisa Afifah Nurmalia
E-Jurnal Medika Udayana Vol 11 No 3 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i03.P11

Abstract

Postoperative pain usually is not handled properly and it may cause discomfort to the patient. The role of analgesia to relieve pain in postoperative patients then becomes very crucial. Ketamine, an NMDA antagonist, is currently gaining attention as an adjuvant analgesia in the management of acute pain. This review will discuss further about the effects of ketamine as an adjuvant analgesia in postoperative patients. Searching literature was performed on the PubMed, Cochrane, and ProQuest databases identifying journals published from 2016 to 2020 that determined the results of ketamine as an adjuvant analgesia in postoperative patients. Writing of this systematic review is based on the systematic review guidelines by the Cochrane Textbook of Systematic Review. There were 6 studies used in this review. Participants involved in this study were patients who received surgery and ketamine intervention as adjuvant analgesia. There were 907 participants who were involved in this study, ranging in age from 18 years to 65 years. There are 4 studies reporting that ketamine can reduce postoperative pain and 2 studies that report no significant effect on postoperative pain. Based on the review conducted, ketamine as an adjuvant analgesia is considered beneficial in reducing postoperative pain in several studies, but the results are not all significant. Thus, it cannot be stated that low doses of ketamine can be effective in reducing postoperative pain.
Antioxidant administration on the incidence of preterm premature rupture of membranes: a literature review Winata, I Gde Sastra; Mahendrata, Prayascita; Wiraputri, Anak Agung Ratih Kusumadewi; Anwar, Meirisa Afifah Nurmalia; Jessica Nathalia
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.75

Abstract

One of the obstetric issues that can lead to consequences for both the mother and the unborn child is premature rupture of membranes (PROM).  In Indonesia, 35% of pregnancies ended in preterm rupture of the membranes in 2013.  The incidence of preterm pregnancy is 2% of all pregnancies, while the incidence of term pregnancy ranges from 6 to 19%.  At 37 weeks gestation, the phrase "premature rupture of membranes" is used.  Preterm premature rupture of membranes (PPROM) is the term used to describe when the membranes burst before birth in women whose gestational age is less than 37 weeks.  It is believed that the pathophysiology of premature membrane rupture involves reactive oxygen species (ROS).  The result of premature membrane rupture is anticipated to be impacted by antioxidant supplementation.
Co-Authors I Ketut Suwiyoga Jessica Nathalia Mahendrata, Prayascita Wiraputri, Anak Agung Ratih Kusumadewi