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All Journal MNJ (Malang Neurology Journal) Jurnal Abdi Kesehatan dan Kedokteran Medic Nutricia : Jurnal Ilmu Kesehatan
Kurnia, Jodii Arlan
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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IMPLEMENTASI PELATIHAN PMKP DALAM TRANSFORMASI STANDAR AKREDITASI: EVALUASI PENINGKATAN PENGETAHUAN DI RSU ABDHI FAMILI Kurnia, Jodii Arlan; Aini, Luthfi; Amrizal, Rizki; Fiqilyin, Corina
Medic Nutricia : Jurnal Ilmu Kesehatan Vol. 14 No. 2 (2025): Medic Nutricia : Jurnal Ilmu Kesehatan
Publisher : Cahaya Ilmu Bangsa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5455/nutricia.v14i2.11810

Abstract

This study examines the effectiveness of training under the Quality and Patient Safety (QPS) in enhancing the knowledge of doctors and non-healthcare staff at RSU Abdhi Famili, in the context of regulatory changes in hospital accreditation from KMK 2022 to KMK 2024. The training approach incorporated interactive material delivery, group discussions, and evaluations using pretests and posttests. A quantitative analysis using paired t-tests revealed a significant improvement in participants’ knowledge, with the proportion of individuals classified as having "good" knowledge rising from 37.5% in the pretest to 82.5% in the posttest (p = 0.000). These findings indicate that the training effectively equips participants with a deeper understanding of national quality indicators, priority indicators, and the application of risk analysis in quality monitoring. However, challenges in the implementation of QPS persist, particularly among non-healthcare staff, highlighting the need for more adaptive and context-specific training approaches. The study recommends the development of interactive training materials, the integration of information technology in quality monitoring, and enhanced cross-sector collaboration as strategic measures to improve service quality and prepare hospitals to meet the latest accreditation standards. Penelitian ini mengkaji efektivitas pelatihan Program Peningkatan Mutu dan Keselamatan Pasien (PMKP) dalam meningkatkan pengetahuan karyawan di RSU Abdhi Famili. Terdapat perubahan regulasi akreditasi rumah sakit dari KMK 2022 ke KMK 2024. Pendekatan pelatihan yang dilakukan meliputi penyampaian materi interaktif, diskusi, serta evaluasi melalui pretest dan posttest. Metode kuantitatif dengan uji T berpasangan digunakan untuk menganalisis peningkatan pengetahuan. Hasil penelitian menunjukkan adanya perubahan signifikan, di mana peserta dengan kategori pengetahuan “baik” meningkat dari 37,5% pada pretest menjadi 82,5% pada posttest (p = 0,000). Temuan ini mengindikasikan bahwa pelatihan efektif dalam membekali peserta dengan pemahaman mendalam mengenai indikator mutu nasional, indikator prioritas, dan penerapan analisis risiko dalam monitoring mutu. Meskipun demikian, tantangan implementasi PMKP masih dirasakan, terutama di kalangan non-tenaga kesehatan, yang memerlukan pendekatan pelatihan lebih adaptif dan kontekstual. Penelitian ini menyarankan pengembangan materi pelatihan yang interaktif, integrasi teknologi informasi untuk monitoring mutu, serta kolaborasi lintas sektoral sebagai strategi untuk meningkatkan kualitas layanan dan kesiapan rumah sakit dalam memenuhi standar akreditasi terbaru.
Fibroblas Terkait Kanker dan Dampaknya terhadap Kelangsungan Hidup Keseluruhan pada Karsinoma Urotelial Kandung Kemih: Suatu Tinjauan Sistematis: Cancer-Associated Fibroblasts and Their Impact on Overall Survival in Bladder Urothelial Carcinoma: A Systematic Review Kurnia, Jodii Arlan; Mardenanta, Vico
Jurnal Abdi Keperawatan dan Kedokteran Vol 5 No 1 (2026): Jurnal Abdi Kesehatan dan Kedokteran
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/jakk.v5i1.166

Abstract

Background: Bladder urothelial carcinoma (BUC) remains a common urologic malignancy with substantial mortality. The tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), promotes extracellular matrix remodeling, angiogenesis, immune evasion, and treatment resistance, suggesting CAFs may serve as prognostic and predictive biomarkers. Objective: To evaluate the association between CAFs and overall survival (OS) in BUC and identify clinically relevant CAF-related markers. Methods: A PRISMA-guided systematic review was performed using PubMed, Cochrane Library, Taylor & Francis, ProQuest, Scopus, and EMBASE (2015–2025). Eligible human studies assessing CAFs/CAF-signatures in BUC were included. Risk of bias was assessed using ROBINS-I. Results: Nine studies were included. Across cohorts, elevated CAF abundance or CAF-related markers consistently correlated with poorer outcomes. High CAF infiltration in TCGA-BLCA was associated with reduced OS (p=0.003) and advanced stage (p<0.001). Stromal markers such as FAP (HR=2.06) and PDGFRβ (HR=1.75) predicted worse OS, with FAP-dominant phenotypes showing the lowest survival. myCAF- and iCAF-high subtypes were linked to shorter OS (e.g., iCAF cluster p=0.024). Multiple CAF-based gene signatures (e.g., 7-gene models) stratified mortality risk (multivariate HR up to 3.51; AUC 0.88). COL10A1 overexpression also predicted inferior OS. A fibroblast-related gene index (FRGI) showed strong performance in ICI-treated patients (1-year OS AUC=0.95) and was enriched in non-responders. Conclusion: CAF abundance and subtype composition are robust adverse prognostic indicators in BUC and show promise for risk stratification and treatment decision support, particularly for immunotherapy responsiveness.
NEUROLEADERSHIP IN HOSPITAL SETTINGS: A SYSTEMATIC REVIEW OF MECHANISMS, APPLICATIONS, AND EVIDENCE GAPS Tazuyyun, Shanaz Hanani; Savira, Tsalsa Dzikria; Kurnia, Jodii Arlan; Yueniwati, Yuyun; Widyaningrum, Kurnia
MNJ (Malang Neurology Journal) Vol. 12 No. 2 (2026): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.02.13

Abstract

Background: Background: Systems in healthcare have become more complicated. Advanced leadership skills need to include the cognitive, emotional, and social aspects. An emerging cross-disciplinary field, neuroleadership, combines neuroscience and leadership, but its use in hospitals is still sparse and further underexplored. Objective: The purpose of this paper is to provide a systematic overview to identify the mechanisms, applications, and research gaps of neuroleadership in hospitals. Methods: A systematic review of the literature was conducted following the PRISMA 2020 guidelines. Searches were conducted in PubMed, Scopus, ProQuest, EBSCO, and ScienceDirect by using a set of predetermined keywords. Studies that were eligible and published in the last 10 years were screened, and the methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool. Results: Nine studies were included in the final review. Findings showed that neuroleadership improves leadership effectiveness via emotional control, cognitive mobility, and social impact. The SCARF (Status, Certainty, Autonomy, Relatedness, Fairness) model was the most used framework in addressing interpersonal relations, engagement of employees, and change in the organization. Neuroleadership is also viewed to enhance transformational leadership by the neurocognitive rationale of motivation and judgment. However, there is a preponderance of conceptual studies over empirical studies. Conclusion: Neuroleadership is a highly encouraging viable alternative to current leadership frameworks in the field of healthcare. This review articulates an integrated framework that connects neurocognitive mechanisms to leadership in hospitals. Forthcoming studies should more empirical evidence with better study design and more measurable outcomes in an organization.
Efektivitas dan Keamanan Pretreatment Inhibitor P2Y12 Dibandingkan Tanpa Pretreatment pada Pasien dengan Sindrom Koroner Akut Non-Elevasi Segmen ST (NSTE-ACS) yang Menjalani Angiografi Koroner Invasif: Sebuah Tinjauan Sistematis: Effectiveness and Safety of P2Y12 Inhibitor Pretreatment Versus No Pretreatment in Patients With Non–ST-Elevation Acute Coronary Syndromes (NSTE-ACS) Undergoing Invasive Coronary Angiography: A Systematic Review Setiawan, Anugrah Puspitasari; Kurnia, Jodii Arlan
Jurnal Abdi Keperawatan dan Kedokteran Vol 5 No 2 (2026): Jurnal Abdi Kesehatan dan Kedokteran
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/jakk.v5i2.184

Abstract

The role of routine P2Y12 inhibitor pretreatment before invasive coronary angiography in non–ST-elevation acute coronary syndromes (NSTE-ACS) remains controversial. While early platelet inhibition may theoretically reduce ischemic complications, contemporary invasive strategies and more potent agents raise concerns about excess bleeding when coronary anatomy and revascularization plans are still unknown. A PRISMA guided systematic review was conducted, including randomized controlled trials and prespecified or post hoc analyses evaluating P2Y12 inhibitor pretreatment versus no pretreatment (or deferred initiation after angiography) in adult patients with NSTE-ACS undergoing an invasive strategy. Searches were conducted in PubMed, the Cochrane Library, and ClinicalTrials.gov. Outcomes included major adverse cardiovascular events (MACE), myocardial infarction, all-cause mortality, and major bleeding. Risk of bias was assessed using Cochrane RoB 2. Findings were synthesized narratively due to clinical and methodological heterogeneity. Six studies met inclusion criteria. Five studies directly compared pretreatment versus no pretreatment, primarily driven by the ACCOAST trial and related analyses, and the DUBIUS trial. Across direct comparisons, pretreatment did not reduce ischemic outcomes (MACE, myocardial infarction, or all-cause mortality) but was consistently associated with higher major bleeding risk (TIMI or BARC definitions), including in clinically relevant subgroups such as patients undergoing PCI. Analyses of pretreatment timing did not demonstrate ischemic benefit even with longer intervals before angiography. In invasively managed NSTE-ACS, routine P2Y12 inhibitor pretreatment does not improve ischemic outcomes and increases major bleeding. Evidence supports deferring P2Y12 initiation until coronary anatomy is defined and a revascularization strategy is clear, favoring a selective, individualized approach.
Co-Authors Aini, Luthfi Amrizal, Rizki Fiqilyin, Corina Kurnia Widyaningrum Mardenanta, Vico Savira, Tsalsa Dzikria Setiawan, Anugrah Puspitasari Tazuyyun, Shanaz Hanani Yuyun Yueniwati