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All Journal Bioma : Berkala Ilmiah Biologi Indonesian Journal of Pharmacology and Therapy
Conara, Flafiani Cios
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Agriculture, Biological Sciences & Forestry Education Immunology & microbiology Medicine & Pharmacology

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Ethanolic Extract of Black Rice ‘Sembada Hitam’ Bran Did not Show Cytotoxic Effect on HeLa Cell (Cervical Cancer Cell Line) Nuriliani, Ardaning; Conara, Flafiani Cios; Oktavya, Galuh; Hidayah, Lailly Tsania Nur; Purwestri, Yekti Asih
Bioma : Berkala Ilmiah Biologi Vol. 25, No 1, Tahun 2023
Publisher : Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/bioma.25.1.49-59

Abstract

Black rice (Oryza sativa L.) contains various phenolic compounds such as anthocyanins which act as antioxidants. Antioxidants inhibit cell proliferation and induced apoptosis of cancer cells as well as protect cells from damage that triggers cancer. 'Sembada Hitam' is a new cultivar of black rice in Indonesia that has not been studied for its anticancer potential. This study aimed to study the cytotoxic activity and apoptosis induction of the ethanolic extract of black rice (Oryza sativa L. 'Sembada Hitam') bran against HeLa cells. The method used was the cytotoxicity test with the MTT assay and the apoptosis test with the AO-PI double staining method. The test used various concentrations of black rice bran extract, DMSO as solvent control, and doxorubicin as a positive control for 24 and 48 hours. Data analysis was performed using one-way ANOVA (p = 0.05) followed by the Tukey HSD test. The results showed that ethanolic extract of black rice 'Sembada Hitam' bran has no cytotoxic activity against HeLa cells (p > 0.05). Moreover, extracts at the concentrations of 250 and 500 µg/mL only induced apoptosis of HeLa cells by 11.62 ± 0.50 and 11.49 ± 9.88% respectively. These results indicate that the ethanolic extract of black rice 'Sembada Hitam' bran has no potential to be developed as an agent for cervical cancer therapy.
Network pharmacology approach to identifying optimal therapeutic targets in cancer drug discovery and development: Bibliometric analysis and scoping review Rovik, Anwar; Henra, Henra; Rahman, Farras Alifia; Afkarina, Izza; Conara, Flafiani Cios
Indonesian Journal of Pharmacology and Therapy Vol 7 No 1 (2026)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.13076

Abstract

A rise in chronic diseases, including cancer, increasingly strains public health. While conventional drug discovery often focuses on single molecules, this method frequently fails to address complex diseases with multiple causes. Network pharmacology, a systems biology approach, provides a more complete understanding of disease mechanisms by analyzing intricate biological networks. By combining multi-omics data and computational models, network pharmacology helps identify new drug targets and cellular pathways. This approach is especially promising in cancer research, where it can reveal complex interactions between genes, proteins, and metabolites. This review explains the principles of network pharmacology and its use in cancer drug discovery. We cover the process, from network building and analysis to experimental testing. Additionally, we examine how network pharmacology can speed up the development of personalized cancer treatments.
Co-Authors Afkarina, Izza Ardaning Nuriliani Henra, Henra Hidayah, Lailly Tsania Nur Oktavya, Galuh Rahman, Farras Alifia Rovik, Anwar Yekti Asih Purwestri