Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Indonesian Andrology and Biomedical Journal Folia Medica Indonesiana
Narulita, Pety
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Non-obstructive Azoospermia in Male with Y-Chromosome Microdeletion: A Case Report Angellee, Jesselyn; Agustinus, Agustinus; Narulita, Pety; Hartanto, Markus Christian; William, William; Suharyani, Sally
Indonesian Andrology and Biomedical Journal Vol. 5 No. 2 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v5i2.64323

Abstract

Male factors have contributed to at least 50% of all infertility cases worldwide. Numerous factors causing male infertility have been identified, one of which is azoospermia due to genetic defects. The detection of Y-chromosome microdeletion may assist in diagnosing male infertility as well as predicting the success rate of testicular sperm extraction. A man in his mid-thirties visited the Andrology outpatient clinic at Dr. Soetomo General Hospital accompanied by his wife. They have been married for eight years and have had regular unprotected sexual intercourse, but pregnancy has never been achieved. The patient’s semen analyses showed azoospermia in three examinations conducted at different times. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were significantly increased, and genetic screening showed microdeletion in the Azoospermia Factor b (AZFb) subregion. Y-chromosome microdeletion is the second most common genetic defect causing azoospermia after Klinefelter syndrome. The AZF region in the distal part of the Y chromosome plays a key role in regulating spermatogenesis. Mutation or loss of any subregions in this factor may affect spermatogenesis, with the worst outcome being azoospermia. Detailed examinations are important to determine the cause of azoospermia, which may assist a physician in choosing the appropriate management for this condition. Infertile men with Y-chromosome microdeletion face challenges in reproducing naturally. They may also need genetic counseling regarding the possibility of passing on this genetic defect to their offspring and information on how to prevent it.
Semen Analysis of Covid-19 Survivors and Uninfected Men: Examining the Motility, Concentration, Vitality, and Morphology Parameters of Spermatozoa Musta'ina, Sri; Siswidiyanto, Eko Budi; Narulita, Pety; Agustinus,; Hinting, Aucky; Atika,; Faizah, Zakiyatul
Folia Medica Indonesiana Vol. 60, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: 1. Spermatozoa can be affected by coronavirus disease 2019 (COVID-19) due to a disruption in spermatogenesis, leading to a decline in semen quality. 2. This study compared the semen quality of COVID-19 survivors and those who had not been infected with COVID-19, specifically on the first spermatogenesis cycle following the confirmation of COVID-19 infection. 3. This study is distinctive since no previous research in Indonesia has examined the semen quality parameters, such as the concentration, morphology, motility, and vitality of spermatozoa, in men who had a COVID-19 infection. Abstract Semen quality in COVID-19 patients shows inconsistencies and variations. This research was conducted considering that health is the main capital for humans in Indonesia's development, as outlined in Sustainable Development Goal 3. The purpose of this study was to compare the semen quality of COVID-19 survivors with non-COVID-19 men. This study was an analytical observational study with a cross-sectional design. Subjects were selected through consecutive sampling of up to 26 men of childbearing age who met the predetermined criteria. Semen quality assessment using the WHO Semen Analysis Guide 6th edition. Quantitative data were analyzed using SPSS. The data normality test was carried out using the Saphiro-Wilk test. Then, the data were tested by t-test from two unpaired samples and by the Mann-Whitney test. Data from semen analysis based on COVID-19 severity were tested using variant analysis (One-way ANOVA) and the Kruskal Wallis test. The normal morphology of spermatozoa in COVID-19 survivors was significantly lower (p=0.011) compared to uninfected men. Other semen quality parameters did not differ significantly, although they were lower in COVID-19 survivors. The results of the analysis also showed no significant difference in semen parameters related to COVID-19 severity (p=0.488 for progressive motility; p=0.372 for non-progressive motility; p=0.325 for total motility; p=0.707 for immotility; p=0.412 for vitality; p=0.324 for concentration; and p=0.334 for normal morphology). The study provides evidence that COVID-19 survivors have a lower normal spermatozoa morphology compared to uninfected men. However, the motility, vitality, and concentration of spermatozoa did not differ significantly between the two groups.
Co-Authors Agustinus Agustinus Agustinus, Angellee, Jesselyn Atika, Aucky Hinting Faizah, Zakiyatul Hartanto, Markus Christian Musta'ina, Sri Siswidiyanto, Eko Budi Suharyani, Sally William William