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Impact of SYNTAX Scores on the Long-Term Outcomes of Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention for Left Main Coronary Artery Disease Murteza, Faiq; Albab, Chabib Fachry; Habibah, Almas Talida; Mas'udi, Achmad Fayyad; Pravitasari, Vemaniarti Lian; Rajanagara, Arya Satya; El-Ma'i, Zaha
Folia Medica Indonesiana Vol. 59, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score was designed to predict the post-procedural risk associated with percutaneous coronary intervention (PCI) or surgical revascularization. This study aimed to evaluate the long-term outcomes of PCI and coronary artery bypass grafting (CABG) by comparing several existing studies. A systematic search was performed using the PubMed (MEDLINE) and ScienceDirect databases. This systematic review included studies that examined differences in the outcomes of PCI and CABG for left main coronary artery (LMCA) stenosis. This was a systematic review study in which we reviewed original cross-sectional and cohort studies. The search was conducted from February 1st until February 2nd, 2023. The quality assessment of the studies was carried out using the criteria outlined in the Newcastle-Ottawa Scale (NOS). According to the final assessment, all the original research included had a mean NOS score of 8, indicating excellent quality. The literature search yielded 1,675 studies, five of which were selected for the final analysis. A total of 5,494 patients underwent PCI and CABG. This study found that there were variations in outcomes among patients with low, medium, and high SYNTAX scores for long-term major adverse cardiac or cerebrovascular events (MACCE) and long-term mortality. However, similar outcomes were observed in long-term revascularization, long-term stroke, and long-term myocardial infarction (MI). This study concluded that patients with LMCA stenosis and SYNTAX scores ranging from low to high may have different long-term outcomes. CABG is associated with a lower incidence of mortality, repeat revascularization, MI, and MACCE compared to PCI. On the other hand, an association exists between PCI and a lower incidence of stroke.
Impact of BMI on Knee Osteoarthritis WOMAC Severity in Adults: A Cross-Sectional Study Rajanagara, Arya Satya; Amru, Basra Ahmad; Putra, Aditya; Djajawiguna, Hafidz Naeriansyah; Iqra, Mohammad Alief; Shafira, Syifa; Putra, ⁠I Putu Wirasatya Eka; Mangun, Dhea JRN
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.992

Abstract

Background: Knee osteoarthritis (OA) is a degenerative joint disease that most often causes pain and disability in adults and the elderly. Risk factors for OA progression include age, gender, physical activity, and body mass index (BMI). Increased BMI is known to contribute to increased mechanical load on the knee joint and trigger inflammation, which can exacerbate OA severity. Objective: To assess the relationship between body mass index (BMI) and the severity of knee osteoarthritis in adult patients. Methods: This is a cross-sectional analytical study conducted at Rheumatology Clinic of Dr. Soetomo General Hospital, Surabaya, in 2019. A total of 42 patients diagnosed with knee OA who met the inclusion and exclusion criteria were enrolled. OA severity was assessed using the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score, while BMI was calculated based on WHO standards and categorized into normal and high (overweight/obese). Analysis of the relationship between BMI and the severity of OA was carried out using the Fisher's Exact Test, with a p value < 0.05 considered significant. Results: Most patients with normal BMI had moderate-severe OA (77.8%), while patients with high BMI were more likely to have very severe OA (58.3%). Fisher's Exact Test showed a significant association between BMI and OA severity (p = 0.0285). Patients with high BMI were more likely to have very severe OA compared to patients with normal BMI (OR ? 4.9; 95% CI ? 1.1–21.5). Conclusion: There was a significant association between increasing BMI and the severity of knee osteoarthritis. These findings emphasize the importance of weight control as part of the prevention and management strategy for knee OA in adult patients.