Science literacy is the integration of science, scientific methods and the way of applying this knowledge in daily life. In addition, socio-cultural literacy skills are also a concern, this is due to the enormous importance of socio-cultural literacy, especially in the life of an increasingly multicultural and complex society like today. Sociocultural literacy helps individuals understand and appreciate diversity, as well as form tolerant and inclusive attitudes. In the era of globalization, there is a lot of interaction between individuals with different cultural backgrounds. This literacy is important so that we can adapt and remain harmonious in differences. These science and socio-cultural literacy skills are very important to encourage a better learning process in science learning with the main goal of encouraging students to be trained in solving problems according to the demands of the 21st century. Science literacy and socio-cultural literacy skills need to be measured to provide an initial overview of the problems that exist related to science and socio-cultural literacy skills in current students. This study aims to describe students' science and socio-cultural literacy skills. This study is a mixed method research with a sequential explanatory design. The research sample was 28 students in grade V of SDN 31 Ampenan which was obtained using the purposive sampling technique. The instruments used were science and socio-cultural literacy test sheets and interview guidelines. Literacy ability data was obtained from students while interview data was obtained from classroom teachers. The data analysis techniques carried out were quantitative descriptive analysis and tringulation. The results showed that students' science literacy ability on the indicators explained scientific phenomena by 32.2%, evaluated and designed scientific investigations by 37.35% and interpreted scientific data and evidence obtained by 30.45%. Meanwhile, the data on students' socio-cultural literacy results on the national commitment indicator was 28.89%, the tolerance indicator was 35.41% and the accommodating and inclusive indicator was 35.70%. This shows that students' science and socio-cultural literacy skills are still relatively low, so it is necessary to make efforts to improve science and socio-cultural literacy through learning that suits the needs of students.