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Girijamma H. A.
RNS Institute of Technology
Computer Science & IT Electrical & Electronics Engineering

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Novel modelling of clustering for enhanced classification performance on gene expression data Sudha V.; Girijamma H. A.
International Journal of Electrical and Computer Engineering (IJECE) Vol 10, No 2: April 2020
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (534.264 KB) | DOI: 10.11591/ijece.v10i2.pp2060-2068

Abstract

Gene expression data is popularized for its capability to disclose various disease conditions. However, the conventional procedure to extract gene expression data itself incorporates various artifacts that offer challenges in diagnosis a complex disease indication and classification like cancer. Review of existing research approaches indicates that classification approaches are few to proven to be standard with respect to higher accuracy and applicable to gene expression data apart from unaddresed problems of computational complexity. Therefore, the proposed manuscript introduces a novel and simplified model capable using Graph Fourier Transform, Eigen Value and vector for offering better classification performance considering case study of microarray database, which is one typical example of gene expression data. The study outcome shows that proposed system offers comparatively better accuracy and reduced computational complexity with the existing clustering approaches.
SCDT: FC-NNC-structured Complex Decision Technique for Gene Analysis Using Fuzzy Cluster based Nearest Neighbor Classifier Sudha V; Girijamma H. A.
International Journal of Electrical and Computer Engineering (IJECE) Vol 8, No 6: December 2018
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (810.688 KB) | DOI: 10.11591/ijece.v8i6.pp4505-4518

Abstract

In many diseases classification an accurate gene analysis is needed, for which selection of most informative genes is very important and it require a technique of decision in complex context of ambiguity. The traditional methods include for selecting most significant gene includes some of the statistical analysis namely 2-Sample-T-test (2STT), Entropy, Signal to Noise Ratio (SNR). This paper evaluates gene selection and classification on the basis of accurate gene selection using structured complex decision technique (SCDT) and classifies it using fuzzy cluster based nearest neighborclassifier (FC-NNC). The effectiveness of the proposed SCDT and FC-NNC is evaluated for leave one out cross validation metric(LOOCV) along with sensitivity, specificity, precision and F1-score with four different classifiers namely 1) Radial Basis Function (RBF), 2) Multi-layer perception(MLP), 3) Feed Forward(FF) and 4) Support vector machine(SVM) for three different datasets of DLBCL, Leukemia and Prostate tumor. The proposed SCDT &FC-NNC exhibits superior result for being considered more accurate decision mechanism.
Co-Authors Sudha V Sudha V.