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POTENTIAL OF OZONE WATER TO REDUCE THE SEVERITY OF ORAL MUCOSITIS IN PATIENTS POST HEAD AND NECK RADIOTHERAPY Annisa Gustiasti Arumsadu; Niluh Ringga Woroprobosari; Rina Kartika Sari; Rochman Mujayanto
Jurnal Medali Vol 3, No 1 (2021): Media Dental Intelektual September 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.v3i1.16965

Background: Cancer is the second leading cause of death in the world after heart disease. One type of cancer, namely head and neck cancer, can be treated with head and neck radiotherapy. Continuous radiotherapy will cause an increase in oxidative stress and free radicals and damage to the oral mucosa, one of which is oral mucositis. Giving ozone water can help reduce the degree of oral mucositis in patients. Ozone water itself has several beneficial effects such as antioxidant, anti-inflammatory, and antimicrobial. The purpose of this study was to determine the potential of ozone water in reducing the severity of oral mucositis in patients after head and neck radiotherapy.Method: Gargling treatment using ozone water in a ratio of 2:3 for 1 minute with 4 repetitions for 2 weeks showed a significant reduction in pain. Ozone used in gas or liquid form for more than 5 minutes has the potential to cause side effects on the duration of inflammation and for gas can cause infection in the respiratory tract.Conclusion: The conclusion of this review is that the administration of ozone water with a concentration of 2-4 ppm for approximately 5 minutes has the potential to cure oral mucositis due to head and neck radiotherapy

PENGARUH SUSU IBU HAMIL TERHADAP EKSPRESI KALLIKREIN-RELATED PEPTIDASE-4 (KLK-4) PADA SEL AMELOBLAS DALAM TUMBUH KEMBANG GIGI Salma Samia; Sandy Christiono; Rina Kartika Sari
ODONTO : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.2.98-103

Background: Tooth development during the embryonic period is a complex process that needs enough nutrition for the formation of healthy dental tissue. Kallikrein-related peptidase-4 (KLK-4) is a serine proteinase secreted by ameloblast during transition and maturation stages in the amelogenesis process which functions to degrade protein matrices so enamel could reach the final hardness. Pregnancy milk contains various nutrients that can increase KLK-4 expression of ameloblast cells in the tooth development. This study aims to determine the impact of pregnancy milk against the KLK-4 expression of ameloblast cell in the tooth development process.Method: 12 pregnant female mice (Mus Musculus L.) divided into control group (given sterile aquadest) and treatment group (given pregnancy milk + sterile aquadest) for 18 days then the tooth germ was taken. Samples were stained to see the KLK-4 expression. Data were analyzed using an Independent sample t-test.Result: Our study showed that the average amounts of KLK-4 expression in the treatment group are higher than the control group. Based on the Independent sample t-test statistic methods, there is a significant difference with the value of p=0,017.Conclusion: The pregnancy milk could influence the Kallikrein-related peptidase-4 (KLK-4) expression of ameloblast cell in the mice fetus’s tooth development.

Analysis of thickness of the epithelial in the cure of oral mucositis due to chemotherapy using 25% pegagan leaf (centella asiatica) extract gel spray Avena Dwi Kunfiar; Rina Kartika Sari; Rahmawati Sri Praptingingsih; Rizki Amalina
Jurnal Medali Vol 5, No 1 (2023): Media Dental Intelektual March 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Cancer treatment with radiotherapy or chemotherapy can cause oral mucositis. Pegagan leaf extract is an herbal alternative with minimal side effects and doesn’t interfere with treatment procedures from chemotherapy cause contains triterpenoid acid, asiaticoside acid, madecoside acid, and saponins that stimulate collagen synthesis which affects epithelialization. This study aims to the difference in epithelial thickness between the administration of 25% pegagan leaf extract (Centella asiatica) spray gel and Gengigel® Hyaluronic acid spray to the healing process of oral mucositis in chemotherapy-induced rats.Method: The design of this study was an experimental laboratory using a post-test only control group design, consisting of 2 groups, namely a positive control group using Gengigel® Hyaluronic acid spray, a group of 25% pegagan leaf extract (Centella asiatica) gel spray. The statistical analysis of the study used the Independent T-test.Result: The results of the spray gel thickness of pegagan leaf extract (Centella asiatica) were 25% greater than Gengigel® Hyaluronic acid spray. The results of the Independent T-test were significant, with a value of p = 0.000 (P <0.05).Conclusion: It can be concluded that there was differences in the increase of epithelial thickness in the application of 25% pegagan leaf extract (Centella asiatica) gel spray with Gengigel® Hyaluronic acid spray on the healing of oral mucositis due to chemotherapy.

PENGARUH SUSU IBU HAMIL TERHADAP EKSPRESI KALLIKREIN-RELATED PEPTIDASE-4 (KLK-4) PADA SEL AMELOBLAS DALAM TUMBUH KEMBANG GIGI Salma Samia; Sandy Christiono; Rina Kartika Sari
Odonto : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Tooth development during the embryonic period is a complex process that needs enough nutrition for the formation of healthy dental tissue. Kallikrein-related peptidase-4 (KLK-4) is a serine proteinase secreted by ameloblast during transition and maturation stages in the amelogenesis process which functions to degrade protein matrices so enamel could reach the final hardness. Pregnancy milk contains various nutrients that can increase KLK-4 expression of ameloblast cells in the tooth development. This study aims to determine the impact of pregnancy milk against the KLK-4 expression of ameloblast cell in the tooth development process.Method: 12 pregnant female mice (Mus Musculus L.) divided into control group (given sterile aquadest) and treatment group (given pregnancy milk + sterile aquadest) for 18 days then the tooth germ was taken. Samples were stained to see the KLK-4 expression. Data were analyzed using an Independent sample t-test.Result: Our study showed that the average amounts of KLK-4 expression in the treatment group are higher than the control group. Based on the Independent sample t-test statistic methods, there is a significant difference with the value of p=0,017.Conclusion: The pregnancy milk could influence the Kallikrein-related peptidase-4 (KLK-4) expression of ameloblast cell in the mice fetus’s tooth development.

EARLY DETECTION OF VERRUCOUS CARCINOMA USING METHYLENE BLUE STAINING IN SUSPECTED LEUKOPLAKIA LESION: A CASE REPORT: DETEKSI DINI KARSINOMA VERUKOSA MENGGUNAKAN PEWARNAAN METILEN BLUE PADA LESI TERDUGA LEUKOPLAKIA: LAPORAN KASUS Rina Kartika Sari; Raziv Ganesha; Esti Kurniawati
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 19 No. 1 (2023): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v19i1.6288

Introduction: Verrucous carcinoma is one of squamous cell carcinoma in the oral cavity which can caused by smoking, alcohol consumption, HPV etc. Verrucous carcinoma can mimick as pre cancer lesion such as leukoplakia, so that early detection is mandatory. Vital staining can be done by toluidine blue, but it reported toxic in organ. Methylene blue had similar chemical structure and exhibited similar physicochemical properties to toluidine blue.The aim of this case report is to report the case of early detection verrucous carcinoma using methylene blue in leukoplakia among smoker and alcoholic patient. Case: A 46-year-old male patient came to RSIGM Sultan Agung Semarang complaint that there was a wound on the left cheek that has not healed for the last 3 years. The wound was not painful but sore when exposed to food. The wound had been treated using Albothyl but there was no change. The patient had been an active smoker since 20 years ago and consume as much as 2-3 packs of cigarettes/day and also consumed alcohol about 4 years ago. Intraoral examination nodular white plaques, unscrappable with pigmentation areas and painless. Clinical diagnosis was nodular leukoplakia. Case Treatment: Early detection using methylene blue 1% was obtained and a positive dark blue indicated a change in malignancy. Patients were given symptomatic therapy of triamcinolone acetonide in orabase 0.1% then an excisional biopsy was performed and a histopathological appearance shows thickening and changes in polarity of the epithelial cells and dysplasia. The final diagnosis is verrucous carcinoma. Conclusion: The persistent white plaque with the risk factors of smoking and alcohol is a suspicion toward malignancy, early detection using methylene blue staining can performed before biopsy.

TREATMENT OF HERPES ASSOCIATED ERYTHEMA MULTIFORME (HAEM): TATALAKSANA HERPES ASSOCIATED ERYTHEMA MULTIFORME (HAEM) Raziv Ganesha; Rina Kartika Sari
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 19 No. 1 (2023): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v19i1.6350

Introduction: Herpes Associated Erythema Multiforme (HAEM) is Erythema multiforme (EM) caused herpes virus infection. EM a caused by an acute hypersensitivity reaction that occurs in the mucocutaneous area. HAEM is hypersensitivity reaction that occurs due to a hypersensitivity reaction to the herpes virus. Case: 17 year old male complaints of itching and dry on his lips since 5 days ago. patient said that ± 7 days ago he had a fever which lasted for 2 days then after the fever went down his lips felt itchy and dry. On clinical examination, desquamation with yellowish brown crusts was found on the vermilion of the upper and lower lips. Case Treatment: patient is given Aloclair® Gel and Becomzet®. Patient is referred for a complete blood count, Total IgE and IgM and IgG HSV-1 antibody testing. The patient was then given hydrocortisone cream 2.5% used 3 times a day. The patient recovered 10 days after the first visit. Discussion: HAEM is triggered by an immunological response in which an immune complex reaction occurs as a result of an immune response to certain antigens such as the herpes simplex virus or certain types of drugs. In cases of HAEM the herpes virus that triggers it is usually HSV-1 & HSV-2. Diagnosis is confirmed by Total IgE and HSV-1 Antibody Tests. Conclucion: Management of cases of HAEM can be successfully determined by establishing the correct diagnosis which requires investigations so that we can rule out the differential diagnosis and provide appropriate treatment

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