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All Journal International Journal of Public Health Science (IJPHS) INDONESIAN JOURNAL OF PHARMACY
Zulies Ikawati
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Health Professions Medicine & Pharmacology

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Gabapentin and Amitriptilin Treatment toward Living Quality of Post Ischemic Stroke Patients with Neurophaty Pain Pinasti Utami; Zulies Ikawati; Setyaningsih Setyaningsih
International Journal of Public Health Science (IJPHS) Vol 4, No 4: December 2015
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (74.925 KB) | DOI: 10.11591/ijphs.v4i4.4742

Abstract

Stroke becomes a significant problem for developing countries. In Indonesia the data show its incidences 234 per 100.000 people, and around 2 - 8 % stroke patients experiencing cerebrovascular session will get neurophaty pain. It happens because of sensoric deviation after stroke, so the brain does not completely send information to the body correctly. Patients experiencing neurophaty pain are able to face decreasing living quality as the effect of long term painful disturbance. Therefore, it is important to maintain the patients’ living quality. The aim of the study is to investigate the comparison of using gabapentin and amitriptilin toward living quality of ischemic stroke patients with neurophaty pain in the hospitals in Jogja. The method used in this study was quasi experimental with consequtive sampling. The study was conducted on 22nd of April-31st of Juli 2013 by involving 23 patients in gabapentin group and 18 patientsin amitriptilin group that would be evaluated during 1 month. Living quality was assessed by Brief Pain Inventory (BPI) in week 0 and week 4. The result of the study showed that the use of gabapentin and amitriptilin in 4 weeks showed the increase of living quality represented by decreasing the score based on BPI questioner 1.67±0.78 and 1.37±0.80 with p-value>0.05 meaning that there was no significant difference. It can be concluded the comparison of using gabapentin and amitriptilin in post ischemic stroke patient with neuropathy pain not significantly increase the quality of in the hospitals in Jogja.
Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus Maria Caecilia Setiawati; Zulies Ikawati; I Nyoman Kertia
Indonesian Journal of Pharmacy Vol 28 No 3, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (910.247 KB) | DOI: 10.14499/indonesianjpharm28iss3pp185

Abstract

Systemic Lupus Erythemathosus  is an autoimmune, inflammatory, chronic disorder characterized by multiorgan system involvement. Depression and anxiety are frequent complaints among patients with lupus erythematosus, so antidepressive treatment should be an important element of the therapy of patients with lupus erythematosus. Research into curcumin’s potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. 4-weeks double-blind, placebo-controlled clinical trial was conducted in 14 SLE patients (10 as treatment group and 4 as control group) The BDI (Beck Depression Inventory) score was calculated and TNF α concentration was measured in the serum subjects before and after treatment. Correlation between TNF α concentration and BDI was assessed. After 4 weeks treatment, the TNF α concentration from subjects in treatment group were significantly lower than before ( p <0.001)  but the BDI score were not significantly lower than before (p = 0.059).  The TNF α concentration and BDI score showed positive correlation, p = 0,024. This  study demonstrate that  Curcuma xanthorrhiza Roxb extract can decrease serum TNF α concentration and  reduce clinically symptoms of depression in SLE patients 
Co-Authors Maria Caecilia Setiawati Nyoman Kertia Pinasti Utami Setyaningsih Setyaningsih