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All Journal JURNAL GIZI INDONESIA Media Penelitian dan Pengembangan Kesehatan Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal NERS Indonesian Journal of Biotechnology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Universa Medicina JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Gizi Klinik Indonesia Journal Of Nursing Practice Indonesian Journal of Rheumatology JPSCR : Journal of Pharmaceutical Science and Clinical Research Ina Kidney Jurnal Pedagogi dan Pembelajaran Nutrisia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Media Farmasi Indonesia Berita Kedokteran Masyarakat Journal of Tropical Pharmacy and Chemistry

Nyoman Kertia

Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Kesehatan Masyarakat, Dan Keperawatan, Universitas Gadjah Mada, Yogyakarta

Author-ID : 297573

Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Relationship Between Systemic Lupus Activity Measurement (SLAM) Score and Mortality in Systemic Lupus Erytemathosus (SLE) Inpatients Paramaiswari, Ayu; Kertia, Nyoman; Achadiyono, Deddy Wachid
Acta Interna The JOurnal of Internal Medicine Vol 4, No 1 (2014): Acta Interna The Journal Of Internal Medicine
Publisher : Acta Interna The JOurnal of Internal Medicine

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ABSTRACTBackground: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder that can be severeand life threatening. Mortality in SLE may due to lupus activity or long-term sequel. Systemic Lupus ActivityMeasurement (SLAM) score is a tool that can count lupus disease activity inpatients.Aims: To analyze the relationship between SLAM score and mortality in lupus inpatients.Methods: Retrospective cohort study used for reaching objective of the study. Lupus inpatients was usedas research population. Medical record was used as study data collection over periods of 2006 until 2011.Independent variable was a SLAM score. The cut point of SLAM score was made based on the mean ofSLAM score (16.7 point score). Dependent variable was mortality.Results: There were differences between number of ACR criteria fi ndings, pneumonia, heart rate withSLAM score (p value 0.001; 0.001; 0.002 respectively).There was a difference of median survival between less and more than 16.7 point score, 45 and 28 respectively (p 0.034). There was a relationship betweenSLAM score (more than 16.7 point score) and mortality HR 2.78 (96% CI 1.01-7.53).There was a differenceof mortality incidence between more and less than 16.7 point score, 0.35 and 0.10 respectively. There wasa relationship between SLAM score (more than 16.7 point score) and mortality RR 3.5 (95% CI). Mortalityin lupus inpatients was 23%.Conclusion: There was a relationship between SLAM score and mortality on lupus inpatients.Keywords: SLE, SLAM, Mortality

Relationship Between Systemic Lupus Activity Measurement (SLAM) Score and Mortality in Systemic Lupus Erytemathosus (SLE) Inpatients Paramaiswari, Ayu; Kertia, Nyoman; Achadiyono, Deddy Wachid
Acta Interna The Journal of Internal Medicine Vol 4, No 1 (2014): Acta Interna The Journal Of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

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ABSTRACTBackground: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disorder that can be severe and life threatening. Mortality in SLE may due to lupus activity or long-term sequel. Systemic Lupus Activity Measurement (SLAM) score is a tool that can count lupus disease activity inpatients.Aims: To analyze the relationship between SLAM score and mortality in lupus inpatients.Methods: Retrospective cohort study used for reaching objective of the study. Lupus inpatients was used as research population. Medical record was used as study data collection over periods of 2006 until 2011. Independent variable was a SLAM score. The cut point of SLAM score was made based on the mean of SLAM score (16.7 point score). Dependent variable was mortality.Results: There were differences between number of ACR criteria fi ndings, pneumonia, heart rate with SLAM score (p value 0.001; 0.001; 0.002 respectively).There was a difference of median survival between less and more than 16.7 point score, 45 and 28 respectively (p 0.034). There was a relationship between SLAM score (more than 16.7 point score) and mortality HR 2.78 (96% CI 1.01-7.53). There was a difference of mortality incidence between more and less than 16.7 point score, 0.35 and 0.10 respectively. There was a relationship between SLAM score (more than 16.7 point score) and mortality RR 3.5 (95% CI). Mortality in lupus inpatients was 23%.Conclusion: There was a relationship between SLAM score and mortality on lupus inpatients.Keywords: SLE, SLAM, Mortality

ANTI-INFLAMMATORY ACTIVITIES OF TEMULAWAK, GINGER, SOYBEAN AND SHRIMP SHELL EXTRACTS IN COMBINATION COMPARED TO DICLOFENAC SODIUM Kertia, Nyoman; Akhadiono, Deddy Nur Wachid; Paramaiswari, Ayu; Fadlilah, Arina Syarifa; Harinawantara, Hangga
Acta Interna The Journal of Internal Medicine Vol 1, No 1 (2011): Acta Interna The Journal of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

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ABSTRACT Background: The prevalence of osteoarthritis (OA) in the community is high. This disease is the second most common cause of physical disability worldwide. Pain in OA is caused by several factors, such as inflammation. Non steroidal anti-inflammatory drugs (NSAIDs) were the most common drugs given worldwide to reduce pain in OA. NSAIDs were also associated with a high incidence of gastrointestinal side effects. An alternative to manage this problem is by using the combination of Curcuma xantorrhyza Roxb. (commonly known as temulawak) extract, ginger (Zingiber officinale) extract, soybean (Glycine max), and shrimp shell. Curcuma xantorrhyza contains curcumin which has anti-inflammatory effect by suppressing cyclo-oxygenase (COX-2) enzyme activity, suppressing lipo-oxygenase enzyme activity, and play a role as a free radical scavenger. Ginger can inhibit COX-2 activity in PGE-2 production. Shrimps shell contains glucosamine and chondroitin which can increase proteoglycan in articular chondrocytes and inhibit COX-2 synthesis. Isoflavone in soybean can inhibit articular cartilage degradation and COX-2 synthesis.Study Aims: The purpose of this study is to compare the effect of the combination to diclofenac sodium in reducing synovial fluid leukocyte count and joint pain in patients with osteoarthritis.Study Method:This study was a prospective randomized open end blinded evaluation (PROBE). Twenty one patients with knee osteoarthritis diagnosed by American College of Rheumatology criteria were included in this study. Patients were randomized into two groups to receive either diclofenac sodium 25 mg (control group) or the combination of Curcuma xantorrhyza extract 50 mg, ginger extract 100 mg, shrimp shell 100 mg, and soy bean flour 50 mg (treatment group) three times daily for 14 days. Independent t-tests and Mann-Whitney-Wilcoxon tests were used to evaluate changes between prior and post intervention.Results: Â There were significantly reduction of synovial fluid leukocyte count in both control group (p=0.017) and treatment group (p=0.008) respectively. Â The reduction of synovial fluid leukocyte count was not significantly different between control group and treatment group (p=0.929).Â There were significant improvement of joint pain (VAS score) in both control group (p=0.012) and treatment group (p<0.001). Â The reduction of VAS score was not significantly different between diclofenac group and treatment group (p=0.607).Conclution: These results indicate that the evicacy of this combiation was not significantly different with diclofenac sodium in reducing the synovial fluid leukocyte count and joint pain in patients with osteoarthritis.Keywords: osteoarthritis, Synovial fluid leukocyte count, Pain, VAS, Diclofenac sodium,Combinaion of curcuma, ginger, shrimp shell and soybean.

PENGARUH KOMBINASI EKSTRAK TEMULAWAK, JAHE, KEDELAI DAN KULIT UDANG TERHADAP FUNGSI HATI DAN GINJAL DIBANDINGKAN DENGAN NATRIUM DIKLOFENAK PADA PENDERITA OSTEOARTRITIS Kertia, Nyoman; M., Nastiti Hemas; G. N., Dewa Ayu
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Untuk menilai pengaruh kombinasi ekstrak rimpang temulawak, jahe, kedelai dan kulit udang dibandingkan dengan natrium diklofenak terhadap fungsi hati dan ginjal pasien osteoartritis. Dua puluh satu subjek dibagi menjadi dua kelompok secara acak (kelompok uji dan kelompok kontrol = kelompok natrium diklofenak). Kelompok uji diberikan terapi kombinasi 50 mg ekstrak temulawak, 100 mg jahe, 50 mg kedelai and 100 mg kulit udang tiga kali sehari, sementara kelompok kontrol diberikan terapi 25 mg natrium diklofenak tiga kali sehari selama dua minggu. Pemeriksaan darah dilakukan sebelum dan setelah 2 minggu terapi untuk menilai kadar enzim hati SGOT dan SGPT dan juga kadar ureum dan kreatinin serum untuk mengamati fungsi ginjal. Desain penelitian ini adalah prospective randomized open end blinded evaluation (PROBE). Pada masing-masing kelompok perlakuan terjadi peningkatan kadar SGOTyang bermakna (p<0.05). Peningkatan SGOT ini tidak berbeda bermakna jika dibandingkan antara kedua kelompok (p=0,312). Pada kelompok uji terjadi penurunan kadar SGPT (p=0,871), sedangkan pada kelompok kontrol terjadi peningkatan kadar SGPT (p=1,000). Peningkatan SGPT ini tidak berbeda bermakna jika dibandingkan antara kedua kelompok (p=0,912). Perubahan kadar ureum pada kedua kelompok tidak berbeda bermakna (p>0,05). Pada kelompok uji terjadi penurunan kadar ureum serum yang tidak bermakna (p=0,214). Baik pada kelompok uji maupun pada kelompok diklofenak tidak terjadi perubahan kadar kreatinin serum yang bermakna (p>0,05). Tidak ada perbedaan yang bermakna terhadap fungsi hati dan ginjal akibat terapi kombinasi ekstrak temulawak, jahe, kedelai dan kulit udang dibandingkan dengan natrium diklofenak selama 2 minggu pada penderita osteoartritis.

Ability of Curcuminoid from Curcuma domestica Val. in Reducing the Secretion of Reactive Oxygen Intermediates by Synovial Fluid Monocytes in Patients with Osteoarthritis Kertia, Nyoman; Asdie, Ahmad Husain; Rochmah, Wasilah; -, Marsetyawan
Indonesian Journal of Biotechnology Vol 16, No 2 (2011)
Publisher : Universitas Gadjah Mada

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AbstractIncreasing the secretion of reactive oxygen intermediates (ROI) by monocytes in the synovial fluid is anindicator to determine the severity of joint inflammation. Previous studies have shown that curcumin inhibitthe osteoarthritis progression with its ability to inhibite the activity of the nitric oxide synthase (NOS) enzymefrom macrophages. In this prospective randomized open end blinded evaluations = PROBE study, 80 patientswith knee osteoarthritis were eligable. The subject were devided in to two group: group who received 3 x 30mg of curcuminoid from Curcuma domestica Val. extract (curcuminoid group) and group who received 3 x 25mg of diclofenac sodium (diclofenac group) as comparison. The treatment was for 4 weeks time. The secretionof ROI by sinovial fluid monocytes was calculated by scoring the amount of formazan formation after neutralred staining in nitrobleu tetrazolium reduction assay. The result of this study showed that the secretion of ROIby synovial fluid monocytes was significantly decreased in both groups (p <0.001) respectively. There wasno significant difference in decreasing of ROI secretion of synovial fluid monocytes between both treatmentgroups (p = 0.92).Keywords : curcuminoid, diclofenac sodium, reactive oxygen intermediates, monocyte, osteoarthritis

Effect of the combination of curcuminoid and essential oil on the serum ureum and creatinine level of patientswith osteoarthritis Kertia, Nyoman; ., Danang
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The curcuminoid of Curcuma domesticaVal. rhizome and the essential oil of Curcuma xanthorrhizaRoxb. rhizome can be used for rheumatic treatment,but no enough data regarding those side effects. This study aimed to determine the efect of curcuminoid of Curcuma domestica Val. combined with essential oil from Curcuma xanthorriza Roxb. to the serum ureum and creatinine level of patients with osteoarthritis. This treatment was compared tothat of piroxicam. This was a Prospective Randomized Open end Blinded Evaluation (PROBE), involving 38 patients with knee osteoarthritis.The treatment group were given the combination of 15 mg curcuminoid of Curcuma domestica Val. and 100 mg essential oil of Curcuma xanthorrhizatwice daily for two weeks. The control group were given 10 mg piroxicam twice daily for two weeks. In the treatment group the serum ureum level decreased 4.58±6.20% mg, while in the control group the ureum level increased 1.68±8.24% mg. In the treatment group the serum creatinine level decreased 0.12±0.36% mg, while in the control group the creatinine level increased 0.18±0.29% mg. Decreasing of serum ureum level in the treatment group was significantly different compared to increasing of that level in the control group (p<0.01). Decreasing of the creatinine level in the teatment group was significantly different compared to increasing of that level in the control group (p<0.01).Key words: Curcuminoid, Essential Oil, Ureum, Creatinine, Osteoarthritis

Effect of the combination of C.domestica extract and essential oil of C.xanthorrhiza roxb. on leucocyte count in synovial fluid compared to that of pyroxicam Kertia, Nyoman; A.D., Imono; ., Mufrod; Catur, Eny; Rahardjo, Poerwono; Asdie, Ahmad Husain
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Osteoarthritis (OA) is the most prevalence rheumatic disease. The non steroidal antiinflamatory drugs display some side effect especially on the gastrointestinal tract, liver, kidney and blood clotting. Kunyit (Curcuma domestica L.) and temulawak (Curcuma xanthorrhiza Roxb.) as natural herbal remedies are developed for antiinflammation, antioxidant and cholagoga. The aim of this present research was to study the effect of combination of Curcuma domestica extract and essential oil of Curcuma xanthorrhiza Roxb on the leucocyte count in the synovial fluid of patient with osteoarthritis compared to that of pyroxicam. A double blind randomized clinical trial was used and conducted at Dr. Sardjito Hospital Yogyakarta. After washed out period the knee synovial fluid was aspirated and the leucocyte count was examined. Patients were randomized for receiving piroxicam capsule 10 mg twice daily or combination of 3,66 ± 0,65 % w/w curcuminoid extract of Curcuma domestica L.and 25 ml essential oil containing curcumen, bergamoten germacren B, Curserenon, Germacron, Xanthorrizol as a major component with 27,64 ± 0,85 % relative concentration of xanthorrhizol each capsule; two times a day for two week period. At the end of this study the synovial fluid was examined. Decreasing the inflamation of synovial area was parrallel with decreasing leucocyte count by 174.56 ± 161.73 per mm3 (p

Studi pharmacovigilance obat di puskesmas X Yogyakarta muthaharah, mustika; Perwitasari, Dyah Aryani; Kertia, Nyoman
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACTÂ The increasingÂ use of herbal medicine in community also increase adverse event and toxicity report. Adverse events and toxicity can be detected with pharmacovigilance system. Adverse Drug Reaction (ADR) of herbal medicines are rarely studied in Indonesia. With the increasing use of herbal medicines in Indonesia, pharmacovigilance studies are necessary to detect the incidence of ADR. The purpose of this study is to describe the incidence of ADR on the use of herbal medicines. This research is a descriptive study using retrospective data. Research was conducted for 3 months by taking 10-month retrospective data backward using medical record. Interviews were conducted to identify the occurrence of ADR and assessment of quality of life using Naranjo algorithm.The result showed that three (13.63%) of 22 patients experiencing the ADR with probability of probable categories (1) and possible (2). The symptom of ADR that showed was the increased frequency of defecation, decreased in stool consistence and diuresis.The results of this study concluded that there are ADR event in patients who have been prescribed herbal medicine in Public Health Center X Yogyakarta.Â Keywords: ADR, herbal medicine, pharmacovigilance.

Diagnostic criteria of knee osteoarthritis in rheumatology outpatient clinic, Dr. Sardjito Hospital, Yogyakarta Kertia, Nyoman; Wachid, Deddy Nur; Krishnan, P N
Indonesian Journal of Rheumatology Vol 3, No 1 (2011)
Publisher : Indonesian Rheumatology Association

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Background: Osteoarthritis (OA) is a chronic condition characterized by the breakdown of joints cartilage. Approximately 25% of persons 55 years of age or older have knee pain on most days and about half of them have radiographic OA in the knee. Prevalence of knee OA increases with age and it is more common in women than men. It is not easy to establish the diagnosis of knee OA since other knee disorders have similar clinicalsigns and symptoms.Objective: The purpose of this study was to observe the diagnosis pattern of knee OA in rheumatology outpatient clinic at Dr. Sardjito Hospital based on clinical and radiographic criteria of American College of Rheumatology (ACR). Method: The design of this study was cross-sectional. Data of the patients with knee OA were investigated from their medical records. Results: There were 212 subjects diagnosed with knee OA during the year 2000â2010. Most of the subjects (90.56%) were more than 50 years old. Women were more frequent affected by OA than men. All of the subjects (100%) had knee pain. Crepitus was found in98.11% subjects. Morning stiffness less than 30 minutes was found in 86.79% subjects. Osteophyte appearances were found in 79.72% subjects.Conclusion: Knee pain, crepitus, and age more than 50 years old were the most frequent criteria used to diagnose knee OA. Morning stiffness less than 30 minutes and osteophyte appearances were also frequent in knee OA.

Studi Pharmacovigilance Obat Herbal Di Puskesmas Kasihan II Bantul Mahdi, Nur; Perwitasari, Dyah Aryani; Kertia, Nyoman
Media Farmasi: Jurnal Ilmu Farmasi Vol 13, No 1: Maret 2016
Publisher : Universitas Ahmad Dahlan

Kejadian Reaksi Obat yang Tidak Dikehendaki (ROTD) dari obat-obat herbal merupakan hal yang masih jarang diteliti di Indonesia. Gaya hidup kembali ke alam menjadi cukup popular saat ini, sehingga masyarakat kembali memanfaatkan berbagai bahan alam, termasuk pengobatan dengan tumbuhan obat atau herbal. Dengan meningkatnya penggunaan obat herbal di Indonesia, maka diperlukan pemantauan keamanan pada obat-obat herbal. Tujuan penelitian ini adalah mengetahui gambaran kausalitas kejadian ROTD serta mengetahui kualitas hidup pasien yang mendapatkan resep obat herbal. Penelitian ini menggunakan rancangan observasional deskriptif, pengambilan data secara consecutive sampling secara prospektif. Pengambilan data selama dua bulan saat penelitian berlangsung, setelah itu dianalisis kejadian ROTD dan tanpa ROTD serta dinilai kualitas hidup pasien. Instrumen yang digunakan untuk menganalisis adalah algoritma Naranjo dan kuesioner SF-36. Hasil wawancara kepada 25 subyek penelitian pada pengamatan prospektif dan retrospektif, subyek yang melaporkan adanya kejadian ROTD sebanyak 3 subyek (12%). Sebanyak 2 subyek dengan kategori possible (mungkin) dan 1 subyek dengan kategori probable (cukup mungkin). ROTD yang muncul adalah gatal-gatal, nyeri pinggang, mual, ngantuk dan dada berdebar. Kesimpulan dari penelitian ini adalah terdapat kejadian ROTD pada pasien yang diberikan terapi herbal, gambaran kausalitas kejadian ROTD adalah kategori possible dan probable. Kata kunci: pharmacovigilance, reaksi obat yang tidak dikehendaki, obat herbal.

Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achadiono, Deddy Achadiono, Dedy Nurwachid Ahmad Husain Asdie Ahmad Husain Asdie Ahmad Husain Asdie Arif Nurrochmad Arif Prassetyo Arina Syarifa Fadlilah Asdie, Achmad Husain Ayu Paramaiswari Ayu Paramaiswari Baiq R Rhadianaa Bambang Udji Djoko Rianto Bambang Udji Djoko Riyanto, Bambang Udji Djoko Danang ., Danang Deddy Nur Wachid Deddy Nur Wachid Achadiono Deddy Nur Wachid Akhadiono Deddy Wachid Achadiyono Dewa Ayu G. N. Dewa Ayu G. N., Dewa Ayu Dyah Ariani Perwitasari Dyah Aryani Perwitasari Ema Madyaningrum Endang Mahati Eny Catur, Eny F, Melani Farah Nuriannisa Gede Kambayana Gunawan, I Made Alit Hangga Harinawantara Haslinda Haslinda Haslinda Haslinda, Haslinda Heru Yulianto I Dewa Putu Pramantara I Made Alit Gunawan I Made Alit Gunawan Ika Puspitaningrum Imono A.D., Imono Indwiani Astuti Irwan Supriyanto Kartyanto, Adhita Khasana, Tri Mei Krishnan, P N Lily Arsanti Lestari M. Marsetyawan Mae Sri Hartati Wahyuningsih Maria Caecilia Nanny Setiawati Maria Caecilia Setiawati Marsetyawan -, Marsetyawan Marsetyawan Marsetyawan Marsetyawan Marsetyawan Metalia Puspitasari Mohammad Robikhul Ikhsan Mufrod ., Mufrod Mustika Muthaharah mustika muthaharah Mustika Muthaharah muthaharah, mustika N. Setiawati, M. Caecilia Nastiti Hemas M. Nastiti Hemas M., Nastiti Hemas Nugroho, Dhite Nunu N Madjid Nur Arfian Nur Mahdi Nurrochmad, Arif P N Krishnan Poerwono Rahardjo Pratiwi, Woro Rukmi Probosuseno Probosuseno Probosuseno Probosuseno, Probosuseno Rochmach, Wasilah Ronny T Wirasto Sinarta, Armin SRI SETIYARINI, SRI Srinalesti Mahanani Sugeng Sugeng Supanji, Supanji Susini R Sari Tri Mei Khasana W.N., Meika Wachid, Deddy Nur Wasilah Rochmah Wasilah Rochmah Wasilah Rochmah Widhiarta, Putu Raka Wiwekananda, Ketut Shri Satya Wiwin Lismidiati Yenny Kandarini Yogiswara, Komang Satvika Yolanda Dyah Kartika Yuliani, Kartika Yulyani Werdhiningsih Z, Ikawati Zulies Ikawati

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