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All Journal HAYATI Journal of Biosciences
. PRAPTIWI
Phytochemistry Laboratory, Research Center for Biology, Indonesian Institute of Sciences Jalan Raya Bogor Km. 46, Cibinong 16911, Indonesia
Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences

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Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr. DEWI WULANSARI; YULIASRI JAMAL; . PRAPTIWI; ANDRIA AGUSTA
HAYATI Journal of Biosciences Vol. 21 No. 2 (2014): June 2014
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (997.942 KB) | DOI: 10.4308/hjb.21.2.95

Abstract

Endophytic fungi have been known to produce a broad range of biologically active secondary metabolites. One endophytic filamentous fungus, Coelomycetes AFKR-18, isolated from the young stems of a yellow moonsheed plant, Arcangelisia flava, has been found to produce pachybasin when placed in a liquid medium. The chemical structure of pachybasin was deduced from MS, 1D-, 2D-NMR spectrum analysis, and from reference data. On a micro-dilution test, pachybasin showed antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 µg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 µg/mL respectively.
Co-Authors ANDRIA AGUSTA DEWI WULANSARI YULIASRI JAMAL