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All Journal Indian Journal of Forensic Medicine & Toxicology
Amit B. Nagdive
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Public Health

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Hyperammonaemia in Absence of Deranged Liver Enzymes with Valproate: A Case Report Amit B. Nagdive; Prakash B. Behere; Siddharth Sethi; Rouchelle Fernandes
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14268

Abstract

Valproate is used for various neurological and psychiatric conditions. It has various adverse effects, mostof which are mild and transient, however, hyperammonaemia in the absence of abnormal liver functionis an uncommon and life-threatening side effect. The exact mechanism for this is unknown, but severalmechanisms have been described for the same. We present a case of 11-year-old male patient belongingto a broken family. Initially he was diagnosed as a case of ADHD with conduct disorder. However due tonon-response to medications, over time, a EEG was done and was found to have generalised epileptiformdischarges, He was maintaining well on Valproate, but had an acute exacerbation of symptoms on beingoff medications for 2 weeks and grandmother restarting Valproate in high dose. Response to the treatmentprovided to the patient was rewarding.
Co-Authors Prakash B. Behere Rouchelle Fernandes Siddharth Sethi