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All Journal Indian Journal of Forensic Medicine & Toxicology
Churdsak Jaikang
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Estimation of Chronological Age from Advanced Glycation End Products Level in Vitreous Fluid Kanicnan Intui; Churdsak Jaikang; Somlada Watcharakhom; Yutti Amornlertwatana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14301

Abstract

Background: Chronological age estimation is an important process for corpse identification. Advancedglycation end products (AGEs) are accumulated during lifetime and have been used for forensic identification.The AGEs in vitreous humor still lack of information for age estimation. Objective: To investigate correlationbetween the AGEs level contained in vitreous humor and chronological age in postmortem cases. Methods:The vitreous humor samples were collected from the postmortem cases (n=142). The AGEs levels weredetermined by spectrofluorometer and presented in microgram of quinidine hemisulfate equivalent (?g QE/mL) and nanogram of pentosidine equivalent (ng PE/mL). Stepwise linear regression was used to generatethe equation. Results: The QE and PE showed mild positive correlation (r = 0.350 and 0.195; p <0.001,respectively) while the PE/QE ratio showed moderate negative correlation with age (r = -0.561, p <0.001).The predicted equation showed error value 12 years and gave accurate prediction in range 40-59 years old.Conclusion: The AGEs contained in the vitreous humor correlated with chronological age in postmortemcases. The other fluorescence molecules might be interfere during the AGEs measurement then the specificmethods should be developed for measuring the AGEs level to decrease the error value.
Gender Differentiation in Tryptophan Metabolism in Postmortem Cases Somlada Watcharakhom; Kanicnan Intui; Yutti Amornlertwatana; Churdsak Jaikang
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15955

Abstract

Tryptophan (TRP) is an essential amino acid and is metabolized via kynurenine and serotonin pathway. Both pathways are significant role in many diseases and have been studied as biomarkers for differentiate and clarify in many diseases including forensic works. Metabolism in the body might be affected by both intrinsic and extrinsic factors. This study aimed to compare postmortem blood level of TRP and its metabolites in male and female to be applied in gender identification in forensic medicine cases. Blood samples were collected from male group (n=11) and female group (n=11) and the level of the TRP and its metabolites were identified by HPLC-DAD. The values of the TRP, metabolites and metabolite ratios did not different between the groups. While, the value of ratio of picolinic acid/ quinolinic acid different significantly (p <0.05) among the groups which might be applied for gender identification in postmortem cases. In conclusion, we found that gender have no effect on the TRP and its metabolites. By the way, the effect of gender should be expanded sample size and develop to gender identification method.
Changing of ATP and Its Metabolites in Blood Samples for Post Mortem Interval: In Vitro Study Warangkool Chanpan; Churdsak Jaikang; Chaturong Kanchai
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 3 (2022): Indian Journal of Forensic Medicine and Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i3.18247

Abstract

Background: Postmortem interval (PMI) is an important in forensic practice. Many studies in blood and tissue ofanimals have revealed correlation between adenosine triphosphate (ATP) level and PMI. In this study aimed toexplore the correlation between human blood ATP and its metabolites level and PMI in vitro model.Methods: Ten milliliter of venous blood samples were collected form four healthy men and contained in EDTAtube. One milliliter of the blood sample was divided at 0, 1, 2, 4, 8, 12 and 24 h, respectively. The blood sampleswere extracted and measured ATP, adenosine diphosphate (ADP) and adenosine monophosphate (AMP) level byHigh performance liquid chromatography- diode array. Energy charge value was calculated to predict charge ofATP metabolites.Results: The blood ATP, ADP and AMP levels increased in the first hour. The blood ATP, ADP and AMP levelsdid not obviously change before 12 hour. The blood ATP level trended to decrease but the blood ADP and AMPlevels trended to increase after 24 hour. Energy Charge was not change in first 12 hour but trended to decreaseafter 24 hour.Conclusion: The blood ATP level and its metabolites changed after 12 hour and apply for the PMI investigation.
Hematological Parameters Alteration in Thai Garlic Farmers Exposed to Mixed Pesticides Chepatee Srilesin; Jirapak Ruttanapattanakul; Yutti Amornlertwatana; Rangsan Watcharakawin; Churdsak Jaikang
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 3 (2022): Indian Journal of Forensic Medicine and Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i3.18263

Abstract

Fungicides, herbicides, and insecticides are commonly agrochemicals used to eliminate pests during garliccultivation. Occupational exposure to mixed pesticides can cause hematological abnormalities. The aim of thisstudy was toassess the adverse effects of chronic mixed pesticide exposure in the garlic farmers by using thehematological parameters. The blood sample was collected from 137 Thai farmers who chronically exposed tomixed pesticide and 59 control group who were not a history of exposure to mixed pesticide. Complete BloodCount (CBC) analysis was performed to investigate the hematological parameters alteration pattern of Thaifarmers. Statistical analysis also performed by using Mann-Whitney U test. Our investigations revealed thatthemean values of white blood cell (WBC) count, lymphocyte, basophil, platelet distribution width, mean plateletvolume and platelet large cell ratio significantly decreased in the chronic exposed group but did not affect whencompared with the normal reference ranges. The results clearly demonstrated that chronic exposure to the mixedpesticides during garlic cultivation alters the hematological parameters. The farmers should be aware and checktheir health to prevent the adverse effects from pesticide intoxication.
Co-Authors Chaturong Kanchai Chepatee Srilesin Jirapak Ruttanapattanakul Kanicnan Intui Rangsan Watcharakawin Somlada Watcharakhom Warangkool Chanpan Yutti Amornlertwatana