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Correlation of Lipid Profile with Thyroid Stimulating Hormone in Pregnant Females Roshni G. Sadaria; Tejas J. Shah; Smita N. Vasava
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14389

Introduction: Pregnancy is a state which requires more metabolic fuels. Changes in the hormonal levelsin pregnancy alter lipid profile also in pregnant women. Thyroid hormone abnormality without any historyof thyroid disease may lead to alteration of triglycerides, phospholipids, total cholesterol, and variouslipoproteins levels in pregnancy which increases the risk for CVS disease.Aim: The aim of the study is to find out the association among TSH and lipid profile in pregnant females.Materials and Methods: The observational study was conducted at Biochemistry Department, SBKSMedical Institute & Research Center, Piparia, Vadodara, Gujarat, India. 100 antenatal cases from wereenrolled after taking an informed consent. 50 pregnant women were in 2nd trimester and 50 pregnant womenwere in 3rd trimester. Blood samples were drawn to estimate lipid profile and TSH. Interpretation of data wasdone using Medcalc software.Results: The mean level of TSH was 1.71(1.26) in 2nd trimester pregnant females and 2.68(0.72) in 3rdtrimester pregnant females, difference between them was statistically significant. Significant negativecorrelation was found between TSH and total cholesterol in 3rd trimester pregnancy. There was a significantpositive correlation was seen between TSH and triglyceride and between TSH and VLDL in 3rd trimester.Conclusion: Significant increase in TSH level is found in 3rd trimester pregnant females compare to 2ndtrimester pregnant females. Significant correlation is also found between TSH and lipid profile in 3rdtrimester. Regular checkups of Thyroid hormones are required in later stages of pregnancy to prevent furthercomplications.

Thyroid Profile and Its Correlation with Serum Creatinine in Chronic Kidney Disease Patients in Tertiary Care Hospital Roshni G. Sadaria; Smita N. Vasava
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14390

Background: Chronic kidney disease (CKD) is defined as abnormalities in kidney structure or functionpresent for > 3 months and have other health implications. Thyroid hormones are important for electrolytehomeostasis and also for the growth and development of the kidney. Study shows that hypothyroidism iscommonly seen in later stages of CKD. This study was conducted to investigate thyroid hormone profile andits correlation with creatinine in CKD patients.Materials and Methods: The present case control study was conducted at Dhiraj General Hospital, Piparia,Vadodara, Gujarat, India in which 100 subjects were enrolled, out of which 50 were cases of CKD patientsand 50 were controls. The age group for the study was 18 to 70 years. Blood samples were drawn to measureblood urea, serum creatinine, thyroid profile. Interpretation of data was done using Medcalc software.Conclusion: Serum TSH levels were high in cases compared to controls but results were not significant.Significant negative correlation was found between free thyroid hormones and serum creatinine. Correlationof creatinine with T3, T4 and TSH were not significant. Subclinical hypothyroidism is found in our populationwith undialyzed CKD. More studies involving large population size are required to ascertain these findings.

Association of BMI with Serum Homocysteine in Polycystic Ovarian Syndrome Women Roshni G. Sadaria; Smita N. Vasava
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14391

Background: Women of reproductive age group are prone for Polycystic ovarian syndrome (PCOS). Recentstudies have shown that hyperhomocysteinemia is a risk factor for cardiovascular diseases. Prevalence ofcardiovascular disease and cardiovascular morbidities in women with PCOS are increased nowadays. Thepurpose of the study is to assess correlation of BMI with serum homocysteine in PCOS females.Materials and Methods: This is done on 50 PCOS patients and 50 voluntary age matched healthy womenwith no menstrual abnormalities as controls. The age group for the cases and controls is 18-35 years. Thestudy was conducted at Biochemistry Department, SBKS MI & RC, Piparia, Vadodara, Gujarat, India.Measurements of BMI and waist circumference were taken. Fasting blood samples were collected forestimation of FBS, Lipid profile and homocysteine. Medcalc software was used for all statistical analysis. Ap-value less than 0.05 (p< 0.05) is considered as statistically significant.Conclusion: Our study has shown significant higher levels of homocysteine in obese PCOS cases whencompared with non-obese PCOS cases. Also, significant higher level of homocysteine and triglyceride areseen in PCOS cases compared to controls. Regular follow up for lipid profile and homocysteine is requiredfor PCOS patients to prevent CVS complications.

Effect of Iron Deficiency Anemia on HbA1c Levels in Patients of Diabetes Mellitus with Controlled Plasma Glucose Levels Smita N. Vasava; Roshni Sadaria; Tejas Shah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14916

Background: Hemoglobin A1C (HbA1c) is an indicator of patient’s glycemic status over the previous 3months. HbA1C levels increase in presence of Iron deficiency anemia.Aim: To analyze the effect of iron deficiency anemia on HbA1c levels in patients of diabetes mellitus withcontrolled plasma glucose levels.Material and Methods: In the present study, total 50 patient of diabetes mellitus with iron deficiencyanemia with controlled plasma glucose levels were taken as a cases and 50 iron-sufficient non-anemichealthy individuals were taken as a controls. Medical history was taken from all participant and data ofHbA1c, ferritin, FBS, hemoglobin, peripheral smear examination, red cell indices were collected fromlaboratory. Statistical analysis was carried out by student’s t-test, Chi-square test, and Pearson’s coefficientof regression.Results: HbA1C level (6.90 ± 0.81%) were increased in iron-deficient individuals as compared to controls.In females, HbA1C (7.08 ± 0.78%) were more elevated than males. When classified on the basis of FBS,HbA1C was elevated more in subjects having FBS between 100-126 mg/dl (7.31 ± 1.52%) compared to thethose with normal FBS (<100 mg/dl).Conclusion: A positive correlation found between iron deficiency anemia and increased HbA1C levels,especially in the controlled diabetic women and individuals having FBS between 100-126 mg/dl. Therefore,presence of iron deficiency anemia should be checked before altering the treatment regimen of diabetesmellitus patient.

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