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All Journal Indian Journal of Forensic Medicine & Toxicology
Aesa Alzaroug Jaber
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The Association between Teeth Loss and Oral Health Problems Aesa Alzaroug Jaber; Alshame M.J.Alshame; Khaled Owidat Abdalla; Prabhu Manickam Natarajan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14608

Abstract

Background: The teeth play various functional roles, from the most basic functions to more subtle functions.One of the most tragic events that can happen to the teeth are loss it, as a result trauma or dental diseases.Tooth loss has esthetic, functional, positional and psychological impacts on the life of individuals.Objectives: To investigate the association between tooth loss and oral health problems among partiallyand completely edentulous patients. Method: (Questionnaire and Clinical Examination). Self-administeredquestionnaire was distributed to the patients to collect information relating to demography and cause oftooth loss, in addition to mastication and speech state after tooth loss. Four clinical conditions includingsupra-eruption, drifting teeth, temporomandibular disorders and bone resorption were used to recognize theeffects of missing teeth. Patients seeking dental treatment at General Hospital, Morzuk, Libya were recruitedfor the study. Criteria included age of 16 years and above with one or more missing teeth except for thirdmolars. Results: altogether 58 participants, 31 (53.4 %) were males while 27 (46.6%) were females. Theparticipants were aged 16–>45 years, among them, 44 patients (75.9%) are partially edentulous, and 14patients (24.1%) were completely edentulous. The patients with complete teeth loss and the patients withmissing both the anterior and posterior teeth are most groups suffer problems among patients who involvedin the study. patients who loss posterior teeth are the lowest group had, suffer of health problems due to lossof teeth among all of them.The general relationship between tooth loss and the oral health problems was positive and strong. Conclusions:there are statistically significant relationship between tooth loss and oral health problems, where the strongvalue of this relationship (0.614) and significance within less than (0.05).
A Case of Multiple Mandibular Molar Extractions for a Hemophilia a Patient Aesa Alzaroug Jaber; Alshame M. J. Alshame; Prabhu Manickam Natarajan; Asok Mathew
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15436

Abstract

Hemophilia A is a genetic coagulation disorder associated with a deficiency of clotting factor VIII. It can be inherited or acquired and have different levels of severity. The present case report describes a Libyan male patient with Factor VIII deficiency who underwent multiple remaining roots extraction.The patient was a 26-year-old Libyan male with history of hemophilia A of mild type. The patient underwent blood tests and imaging to assess the severity of hemophilia and the condition of the surgical area. The blood examination revealed normal Bilirubin level (0.6), low levels of, RBC (4.55), HGB (10.9), PT (17.7) and slight changes in platelet count and Factor VIII level. The treatment plan for the day of surgery was accordingly, the patient was administered Factor VIII 24 hours before the day of surgery. The patient underwent the multiple roots extraction of lower left first and second molar under local anesthesia using 2% Lidocaine with 1:80, 000 Adrenaline. The Injection technique was regional nerve block (inferior alveolar, Lingual, and long buccal nerve block).After extraction, direct pressure on the area using a damp gauze swab, maintained for at least 30 min, a hemostat and multiple thread suture were applied. One hour after surgical removal of the roots again the patient administered Factor VIII.There was no subsequent bleeding or complications at follow-up in the first three days. In the fourth day there was moderate bleeding at the extraction sockets continued for a day. At fifth day the patient was admitted at the Sebha Medical Centre. The bleeding stopped after 24 hours. Treatment plan in the Medical Centre was administration of factor FVIII, tranexamic acid 500 mg three times a day and vitamin K once a day. All injections were given intravenously. Then the patient discharged from the Centre in the sixth day after bleeding controlled. The wound had healed completely without abnormalities.
Analysis of MCL-1 Copy Number Variation in Non-Small Cell Lung Cancer Almahdi Alzaroukh Jaber; Howard Pringle; David Guttery; Aesa Alzaroug Jaber
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15579

Abstract

Amplification of the MCL-1 gene induces MCL-1 overexpression, which is an important marker for drug resistance in several malignancies through evasion of apoptosis. We analysed 39 lung adenocarcinomas (ADCs), 38 lung squamous cell carcinomas (SCCs), two large cell lung carcinomas (LCCs) and cell lines. A duplex ratio test TaqMan qPCR approach was performed for MCL-1 copy number change analysis and we demonstrated amplification of MCL-1 in H1395 cell line and copy number gain (isochromosome) in H2342 cell line. Immunohistochemistry (IHC) and in situ hybridization (ISH) were performed for protein and mRNA analysis respectively. MCL-1 amplification was detected in 13% and 2.5% of SCCs and ADCs respectively. MCL-1-amplified tumours demonstrated high expression of MCL-1 mRNA. Copy number gain was detected in 2.5 % of ADC but not SCC.
Co-Authors Almahdi Alzaroukh Jaber Alshame M. J. Alshame Alshame M.J.Alshame Asok Mathew David Guttery Howard Pringle Khaled Owidat Abdalla Prabhu Manickam Natarajan