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All Journal Indian Journal of Forensic Medicine & Toxicology
Ghusoon G Al- Janabi
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Pathophysiology of Sickle Cell Anemia : Review Article Ghusoon G Al- Janabi; Ali A. Al-Fahham; Ruqaya kareem Mohammed
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14663

Abstract

About 5–7% of the world population have an unhealthy hemoglobin (Hb) gene . The most common form ofhemoglobinopathy globally is sickle cell disease. Sickle cell disorder (SCD) is the major predominant innateclutter of Hb amalgamation stamped through a change within the ? globin gene, which result within thesubstitution of glutamate corrosive with valine at the 6th codon and union of Hb S a which is a hemoglobin,beneath hypoxic states, coming about within the abnormality of RBCs (Red Blood Corpuscles). The lysis oferythrocytes result in raise in extracellular hemoglobin, hence hoisting liking and official to open nitric oxideor antecedents of nitric oxide in this manner diminishing its levels and assist partaking to vasoconstriction .Sickle ruddy blood cells since of their hardness to stream by means of the micro-circulation, results in visitvaso-occlusive scenes, destitute micro-vascular blood stream, ischemic damage, and myocardial localizednecrosis . The clinical highlights of sickle cell anemia are constant hemolytic weakness, an elevatedvulnerability to diseases, repetitive difficult Vaso-Occlusive Emergency (VOC) and a brought down lifehope .
Effect of Cyanide on the Liver Histological and Biochemical Status Dhurgam Jameel Mohamed; Ghusoon G Al- Janabi; Abbas Natroud Bashi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14703

Abstract

The biochemical and histological response of the rats following dosed on the potassium cyanide wasexamined in this study, about 36 rats were randomly divided into sex groups ; G0 which considers the controlgroup, G1 oral dosed with potassium cyanide concentration 500ppm (500U/L), G2 dosed with concentration1000ppm (1g/L), waiting for a long time 21 days before anatomy the animal. G3, G4, and G5 dosed with2000ppm, 2500ppm, and 3000ppm, respectively to study the effect of high dose concentration on the liverhistology, liver enzyme and lipid profile and determined LD50 (lethal dose), and LC50 (lethal concentration).After anatomy, the animal experiment to study the liver histological and determine the effect of potassiumcyanide concentration on the liver enzymes such as HDL, triglyceride, and cholesterol, compared the resultwith the control group and previous studies . The study indicated the presence of a significant increase (P?0.05) in ALP in the G1 , a non-significant increase (P? 0.05) in the G2 , the G3 and G4 groups suffered froma significant increase (P? 0.05) while the G5 group suffered from a non-significant decrease (P? 0.05) incomparison with G0. The present study also showed that there was a significant increase (P ? 0.05) in GPT inthe G1 , G2 , G3 , G4 in comparison with G0. The study also indicated the presence of a significant increase(P ? 0.05) in GOT In the G1 , G2 and G3 compared to the G0.
Biochemical Study of Some Parameters in Patients with B- Thalassemia in Karbala City Ruqaih K Al-kenany; Ghusoon G Al- Janabi; Sajaa R Al-Saedi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14893

Abstract

This study is intended to estimate some biochemical parameters in the adult men with ß- thalassemiamajor and compared with control group. Twenty Iraqi beta- thalassemia major (TM) patients are employedfrom thalassemia center in Karbala city at age of 15-25 years . The body mass index (BMI) of patients wascalculated by measuring weight and high of patients , and the concentration of platelets ,Total cholesterol(TC),Triglyceride(TG),Low density lipoprotein (LDL) ,high density lipoprotein(HDL), Alanine aminotransferase (ALT), Aspartate transferase (AST), Antidiuretic hormone (ADH),Growth hormone (GH),Triiodothyronine (T3) ,Thyroxin (T4), Thyroid stimulating hormone (TSH),Testosterone hormone, Ureaand Creatinine were measured in thalassemic patients and compared with healthy control group. Theresults display that significant decrease (p<0.05) in serum levels platelets, HDL, ADH, GH, TSH, T3, T4,Testosterone hormones and creatinine in patients with ß- thalassemia and showed significant rise (p<0.05)in serum Tc, TG, LDL, ALT, AST and Urea levels in thalassemic group compared with healthy group .andthe results demonstration that significant lower in BMI in group of patients compared with control group.we can be concluded from the present study ,that iron overload state influence on some endocrine glandssecretions, liver and kidney functions.
Co-Authors Abbas Natroud Bashi Ali A. Al-Fahham Dhurgam Jameel Mohamed Ruqaih K Al-kenany Ruqaya kareem Mohammed Sajaa R Al-Saedi