Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Indian Journal of Forensic Medicine & Toxicology
Ruqaya kareem Mohammed
Unknown Affiliation
Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Pathophysiology of Sickle Cell Anemia : Review Article Ghusoon G Al- Janabi; Ali A. Al-Fahham; Ruqaya kareem Mohammed
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14663

Abstract

About 5–7% of the world population have an unhealthy hemoglobin (Hb) gene . The most common form ofhemoglobinopathy globally is sickle cell disease. Sickle cell disorder (SCD) is the major predominant innateclutter of Hb amalgamation stamped through a change within the ? globin gene, which result within thesubstitution of glutamate corrosive with valine at the 6th codon and union of Hb S a which is a hemoglobin,beneath hypoxic states, coming about within the abnormality of RBCs (Red Blood Corpuscles). The lysis oferythrocytes result in raise in extracellular hemoglobin, hence hoisting liking and official to open nitric oxideor antecedents of nitric oxide in this manner diminishing its levels and assist partaking to vasoconstriction .Sickle ruddy blood cells since of their hardness to stream by means of the micro-circulation, results in visitvaso-occlusive scenes, destitute micro-vascular blood stream, ischemic damage, and myocardial localizednecrosis . The clinical highlights of sickle cell anemia are constant hemolytic weakness, an elevatedvulnerability to diseases, repetitive difficult Vaso-Occlusive Emergency (VOC) and a brought down lifehope .
Co-Authors Ali A. Al-Fahham Ghusoon G Al- Janabi