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All Journal Indian Journal of Forensic Medicine & Toxicology Denta: Jurnal Kedokteran Gigi
Agus Subiwahjudi
Unknown Affiliation
Dentistry Public Health

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Effect of Extract and Caffeic Acid Phenethyl Ester on Apoptosis of Odontoblast Cells Ira Widjiastuti; Agus Subiwahjudi; M. Aditya Syahputra; Grace Angelina Samuel; Ni Putu Sawitri Mega; Cinitra Anindya
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14765

Abstract

Background: Propolis is a resinous hive product collected by bees from tree buds and mixed with secretedbee wax to both avoid bacterial contamination in the hive and seal it. It is known to have a wide spectrumof pharmacological properties, including anti-inflammatory, antioxidant, antibacterial, antiviral, and antifungal abilities. Apoptosis tests were performed on odontoblast cells in rats (Rattus novegicus) to assessthe viability of propolis extract and caffeic acid phenetyl esters (CAPE) as alternative candidates for pulpcapping agents in conservative dentistry treatment. Objective: To examine the apoptosis activity of propolisextract and CAPE as capping materials on odontoblast cells. Methods: This study was designed as a posttest only control group laboratory experiment. The rats were randomly divided into three groups. Pulpexposures were performed on the occlusal surface of the right maxillary first molars. In the first group, thecontrol group, glass ionomer cement (GIC) was directly applied to the pulp exposure. In the second group,the sample group, propolis extract was applied to the pulp exposure, and in the third group, CAPE wasapplied to the pulp exposure. All cavities were then filled with GIC as a permanent filling. Animals weresacrificed on the first and fourteenth days. The direct counting method of histological examination was basedon the apoptotic odontoblasts, using the terminal deoxyribonucleotidyl transferase dUTP nick end labeling(TUNEL) assay technique. Result: There was a greater number of apoptotic odontoblasts in the controlgroup, followed by the CAPE group and, lastly, the propolis extract group. Conclusion: The apoptosisactivity of the propolis extract is lower than that of CAPE.
Daya Antibakteri Ekstrak Daun Beluntas (Pluchea Indica Less) Terhadap Streptococcus Viridans (In Vitro) Agni Febrina Pargaputri; M. Mudjiono; Agus Subiwahjudi
Denta Journal Kedokteran Gigi Vol 9 No 1 (2015): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Abstract

Background: Pluchea indica Less leaves is a species of plants that has several chemical properties. It consists of flavonoids, tanine, and essensial oil which had been reported as antibacterial agents. Streptococcus viridans is the most common bacteria found in infected root canal teeth, and the extract of Pluchea indica Less leaves could be potentially used as one of root canal sterilization dressing in root canal teeth. Purpose: The aim of this study was to determine antibacterial activity and Minimum Bactericidal Concentration (MBC) of Pluchea indica Less leaves extract against Streptococcus viridans. Materials and Methods: The antibacterial testing of Pluchea indica Less leaves extract was performed using dilution method against Streptococcus viridans. The tube with concentration extract of 25% was showed no visible turbidity, while the tube with concentration extract of 12,5% was showedgrowth of Streptococcus viridans. We made range between concentration 12,5% until 25% to determine the Minimum Bactericidal Concentration (MBC) of Pluchea indica Less leaves extract. The result of antibacterial activity of Pluchea indica Less leaves extract was determined by measure the growth of Streptococcus viridans using colony count. Result: The result showed that Pluchea indica Less leaves extract was able to inhibit the growth of Streptococcus viridans on concentration 12,5%-25%. The results of Anova statistical test (significant value <0,05) showed significant different among each concentration of Pluchea indica Less leaves extract. Conclusion: Pluchea indica Less leaves extract had antibacterial activity against Streptococcus viridans. Minimum Bactericidal Concentration of Pluchea indica Less leaves extract was performed in concentration 12,5%-25%, which was could kill more than 99% growth of Streptococcus viridans.
Co-Authors Agni Febrina Pargaputri Cinitra Anindya Grace Angelina Samuel Ira Widjiastuti M. Aditya Syahputra M. Mudjiono Ni Putu Sawitri Mega