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All Journal Denta: Jurnal Kedokteran Gigi
Agni Febrina Pargaputri
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Dentistry

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Degrees of Epithelial Dysplasia in Tounge induced by Candida albicans in Immunosupressed Condition Dwi Andriani; Agni Febrina Pargaputri; Syamsulina Revianti
Denta Journal Kedokteran Gigi Vol 13 No 2 (2019): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Candida albicans is a common opportunistic pathogen that play a significantrole in Oral candidiasis and mucosal carcinogenesis. Several studies founD that Candida sp.associated with dysplastic alteration in the epithelium. Candida present in oral cavity withepithelial change is one of predisposing factor of candida infection and lead to atypia to dysplasia. Immunosupression condition is predisposition factor of oral candidal infection.Objective: To investigate the degree of epithelial dysplasia in tounge induced by Candidaalbicans in immunosuppred condition. Methods: This study was true experimental withposttest-only control group design. Sixteen healthy male Rattus novergicus (Wistar), 12 weeksand 200-250 g weight, were immunosuppressed through oral administration ofdexamethasone and tetracycline for 21 days and induced with C.albicans (ATCC-10231) 1Mc.Farland. The subjects were divided into 4 groups (n=4/group): healthy (HG),immunosuppressed (IG), Immunosupressed+Candida albicans (ICG), and nystatintreatment(NG). The subjects were treated for 14 days, later the rats were euthanized and theirtongue being biopsied. Epithelial dysplasia was subjected to HE examination, observed undera microscope (400x magnification) and statistically analyzed (Kruskall wallis, Mann withey, p<0.05). Result: Epithelial dysplasia of IG was the heaviest than other group. No eptithelialchange were found in group HG. Significant differences existed between HG with othergroups; IG with ICG; ICG with NG (p<0.05). No significant differences was present betweenIG and NG (p > 0.05). Conclusion: There was epithelial change in the tongue both inimmunosupressed condition with or without induction Candida albicans. Degree of epithelialdysplasia in tounge induced by Candida albicans in immunosupressed condition group wasthe heaviest than other group.
Innovation of Hyperbaric Oxygen Therapy and Stichopus hermanii to The Amount of Macrophages in Periodontal Ligaments in Pressure and Tension Areas During Orthodontic Tooth Movement Jessica Jenuary Yasin; Arya Brahmanta; Agni Febrina Pargaputri
Denta Journal Kedokteran Gigi Vol 13 No 1 (2019): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: The prevalence of malocclusion in Indonesia reaches 80%, causing orthodontic treatment needs to increase. Orthodontic treatment takes a long time around 15-24 months so additional therapy is needed to accellerate the orthodontic treatment process. Hyperbaric oxygen therapy (HBOT) and Stichopus hermanii (golden sea cucumber) which contain bioactive ingredients can work synergistically to reduce inflammatory cytokines. Purpose: To determine the effect of HBOT and Stichopus hermanii on the number of macrophages in periodontal ligament of pressure and tension area in the process of orthodontic tooth movement. Material and Methods: This research used Randomized Post Test Only Control Group Design. A sample of 30 marmot was randomly divided into 5 groups: negative groups (K-), positive groups (K+), Stichopus hermanii treatment group (P1), HBOT group (P2), and combination (P3). On K+ and treatment groups, maxillary incisors of marmot is installed helical spring in order to move the teeth to distal. Analysis of the number of macrophages histologically using Hematoxylin Eosin (HE) staining. And then tested using the Kruskal-Wallis test, and the Mann Whitney Wilcoxon test. Result: The research data showed a decrease of mean average number of macrophages in the pressure area, K (-): 1.90 ± 0.41; K (+): 4.40 ± 1.14; P1: 4,30 ± 0,90; P2: 3.60 ± 0.54; P3: 2.90 ± 0.41 and the mean number of machrophages in tension area also descreased, K (-): 2.00 ± 0.35; K (+): 4.00 ± 1.00; P1: 4,30 ± 0,27; P2: 4,10 ± 0,65; P3: 3.60 ± 0.65. Conclusion: The combination of HBOT and Stichopus hermanii decreases the number of macrophages in the pressure and tension area in orthodontic tooth movement.
The Effect of Hyperbaric Oxygen Therapy to the Amount of Lymphocytes in Oral Candidiasis Immunosuppressed Model Agni Febrina Pargaputri; Dwi Andriani
Denta Journal Kedokteran Gigi Vol 12 No 2 (2018): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Oral candidiasis generally caused by Candida albicans with prevalence of 30-50%. C. Albicans proliferation in the oral cavity was canducted by decreasing immune system of the host. Lymphocytes activation in immune system happened when there is a contact between host cell with cell wall of C. albicans as a result of C. albicans antigen. One of therapy to suppress the Candida infection sistemically is by giving hyperbaric oxygen therapy. Purpose: To determine the effects of giving hyperbaric oxygen therapy to the amount of lymphocytes in oral candidiasis immunosuppressed models. Methods: This research was post test only control group design. We used 12 wistar rats which were divided into 3 groups(n=4/3): K-(normal/ healthy wistar rats), K+(oral candidiasis immunosuppressed wistar rats), P1(oral candidiasis immunosuppressed wistar rats which were given hyperbaric oxygen therapy 5 days). K+ and P1 groups were immunosuppressed by giving dexamethasone 0,5mg/day/rat orally for 14 days, added with tetrasiklin 1 mg/day/rat. On the 3rd day immunosuppression, the rats were inducted with C.albicans smeared in the dorsum linguae once every two days for 12 days. Results: The data were analyzed with one way Anova test and showed significant difference among groups (p<0,05). To show the difference between each groups we used LSD test and showed significant difference (p<0,05) between K+ compared with P1, and K+ compared with K-. Conclusion: Hyperbaric oxygen therapy gives effect to the amount of lymphocytes in oral candidiasis immunosuppressed models.
The Effect of Brown Algae Sargassum sp. Extract Towards The Amount of Macrophages in The Healing Process of Traumatic Ulcer Annisa Rahmawati; Agni Febrina Pargaputri; Isidora Karsini S
Denta Journal Kedokteran Gigi Vol 12 No 1 (2018): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: The Sarggasum’s sp. extract contains of several chemical properties such as flavonoid, vitamin A, vitamin C, zinc, and calcium which has benefit as anti-inflammation, so it can be used as an alternative therapy for traumatic ulcer. Purpose: To investigate the effectivity of Sargassum’s sp. extract towards the amount of macrophages in the healing process of traumatic ulcers. Material and Method: 32 wistar rats were divided into 4 groups, K1 the negative control group without treatment, K2 the positive control group with the drugs containing 0.2% hyaluronic acid, and the treatment group K3 Sargassum’s sp. extract concentrations of 50% and K4 Sargassum’s sp. extract concentrations of 75%. Traumatic ulcer were made in the labial mucosa of rats by using heated amalgam stopper. On the fourth and seventh day, rats were sacrified and biopsied on lower labial mucosa. The macrophages were observed using a 1000x magnification light microscope with OptiLab viewer. Result: The statistical test using One Way ANOVA showed significant difference (p<0,05) of macrophage on fourth day group. The LSD test showed a significant difference (p<0,05) in macrophages at K1 (2.83±1.03) compared to K3 (1.17±0.64), K1 compared to K4 (0.58±0.79), K2 (2.58±0.50) compared to K3, and K2 compared to K4 at the fourth day group, whereas the seventh day group showed no significant differences between each groups. Conclusion: The Sargassum’s sp. extract concentrations of 75% is the most effective in decreasing amount of macrophages in the healing process of traumatic ulcers.
The Effect of Pluchea indica Less Leaves Extract Againts Biofilm of Enterococcus faecalis and Fusobacterium nucleatum In Vitro Agni Febrina Pargaputri; Elly Munadziroh; Retno Indrawati
Denta Journal Kedokteran Gigi Vol 11 No 1 (2017): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Enterococcus faecalis and Fusobacterium nucleatum are the most common bacteria found in infected root canal teeth and most of them often caused failure in endodontic treatments. These bacteria can form biofilm which makes them more resistant against antibacterial agents. Biofilm formation also causes a decrease in antibiotics and antimicrobials sensitivity. Pluchea indica Less leaves is a species of plants that has several chemical properties. It consists of flavonoids and polyphenols which have benefits to inhibit biofilm formation. Because of its benefits, the extract of Pluchea indica Less leaves can be potentially developed as one of sterilization dressing in root canal teeth. Purpose: The aim of this study was to determine biofilm formation inhibition of Pluchea indica Less leaves extract against Enterococcus faecalis and Fusobacterium nucleatum. Materials and Methods: The dilution method was done first to show the Minimum Inhibitory Concentration (MIC) of the extract. The inhibition biolfilm formation was tested using microtitter plate assay by measuring the bacterial biofilm Optical Density (OD) from ELISA reader’s results and using autoagregation assay to show the inhibition of adherance bacteria. The Pluchea indica Less leaves extract concentration used for inhibition of biofilm formation were 100%, 50%, 25%, 12,5%, and 6,25%. Results: The result of biofilm formation inhibition showed that Pluchea indica Less leaves extract were able to inhibit Enterococcus faecalis and Fusobacterium nucleatum’ biofilm formation with strong moderate effect. The autoagregation assay showed a decrease in autoagregation percentation of Enterococcus faecalis and Fusobacterium nucleatum. Conclusions: Pluchea indica Less leaves extract has effect to inhibit biofilm formation of Enterococcus faecalis and Fusobacterium nucleatum.
Daya Antibakteri Ekstrak Daun Beluntas (Pluchea Indica Less) Terhadap Streptococcus Viridans (In Vitro) Agni Febrina Pargaputri; M. Mudjiono; Agus Subiwahjudi
Denta Journal Kedokteran Gigi Vol 9 No 1 (2015): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Pluchea indica Less leaves is a species of plants that has several chemical properties. It consists of flavonoids, tanine, and essensial oil which had been reported as antibacterial agents. Streptococcus viridans is the most common bacteria found in infected root canal teeth, and the extract of Pluchea indica Less leaves could be potentially used as one of root canal sterilization dressing in root canal teeth. Purpose: The aim of this study was to determine antibacterial activity and Minimum Bactericidal Concentration (MBC) of Pluchea indica Less leaves extract against Streptococcus viridans. Materials and Methods: The antibacterial testing of Pluchea indica Less leaves extract was performed using dilution method against Streptococcus viridans. The tube with concentration extract of 25% was showed no visible turbidity, while the tube with concentration extract of 12,5% was showedgrowth of Streptococcus viridans. We made range between concentration 12,5% until 25% to determine the Minimum Bactericidal Concentration (MBC) of Pluchea indica Less leaves extract. The result of antibacterial activity of Pluchea indica Less leaves extract was determined by measure the growth of Streptococcus viridans using colony count. Result: The result showed that Pluchea indica Less leaves extract was able to inhibit the growth of Streptococcus viridans on concentration 12,5%-25%. The results of Anova statistical test (significant value <0,05) showed significant different among each concentration of Pluchea indica Less leaves extract. Conclusion: Pluchea indica Less leaves extract had antibacterial activity against Streptococcus viridans. Minimum Bactericidal Concentration of Pluchea indica Less leaves extract was performed in concentration 12,5%-25%, which was could kill more than 99% growth of Streptococcus viridans.
Co-Authors Agus Subiwahjudi ANNISA RAHMAWATI Arya Brahmanta Dwi Andriani Elly Munadziroh Isidora Karsini S Jessica Jenuary Yasin M. Mudjiono Retno Indrawati Roestamadji Syamsulina Revianti