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All Journal Indian Journal of Forensic Medicine & Toxicology
Orooba Mohammed Saeed Ibrahim
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Public Health

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Pharmacokinetic Parameters of Meropenem in the Plasma and Milk of Ewes Mustafa Ahmed Jasim Al-Jumaili; Orooba Mohammed Saeed Ibrahim
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14826

Abstract

This study had been designed to evaluate the pharmacokinetic parameters of Meropenem in plasma andmilk of ewes after intravenous bolus adminsteration, for this purpose, five healthy miking ewes had beenreceived a single intravenous bolus of Meropenem (20 mg/kg) to characterize both of distribution andelimination of Meropenem in plasma and milk, concentrations of Meropenem in plasma and milk hadbeen analyzed by microbiological method and pharmacokinetic data had been analyzed by compartmentaland noncompartmental methods, results of mean ± standard deviation for half-life, volume of distributionand total body clearance for plasma samples were 0.67 ± 0.09 h., 0.169 ± 0.01 and 0.3 ± 0.02 L/hr/kg,respectively, the plasma protein binding ratio were 7.27 ± 0.22 %; while the half-life, Cmax and drugpenetration ratio for milk samples were 9.56 ± 3.13 h, 3.91 ± 0.99 ?g/ml and 0.86 ± 0.23 respectively. Inour conclusions; Depending on the approval state of Meropenem for veterinary therapy, we think that theachieved pharmacokinetic parameters of Meropenem in plasma and milk of ewes will candidate it to be oneof the preferred parentrally administered antibacterial agents to encounter the acute cases of mastitis thatought to be treated hastily.
Rationale and Dose Regimen for Sitagliptin/ Glimepiride Combination Therapy in Type 2 Diabetes Treatment Mohammed Hamid Mohammed; Orooba Mohammed Saeed Ibrahim
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15981

Abstract

This study explores how glimepiride, alone or in combination with sitagliptin, affected glycemic control inType 2 diabetes patients. Type 2 diabetes was induced in rats by feeding them a high-fat diet and injectingthem with Alloxan and nicotinamide. Forty-two rats were divided equally into seven groups. Negativecontrol and group 2-7: rats fed with the HFD Positive control (diabetic non-treated) Group (T1, T2, T3, T4and T5) were treated with monotherapy and combination. All the treatment regimen reduces fasting bloodglucose and enhanced GLP-1 and insulin level as indicated by an increase in the area under the curve.Additionally, as opposed to monotherapies, the combination category had better glycemic regulation. As aresult, we assume that sitagliptin/glimepiride combined therapy has a synergistic effect.
Co-Authors Mohammed Hamid Mohammed Mustafa Ahmed Jasim Al-Jumaili