<![CDATA[This study had been designed to evaluate the pharmacokinetic parameters of Meropenem in plasma andmilk of ewes after intravenous bolus adminsteration, for this purpose, five healthy miking ewes had beenreceived a single intravenous bolus of Meropenem (20 mg/kg) to characterize both of distribution andelimination of Meropenem in plasma and milk, concentrations of Meropenem in plasma and milk hadbeen analyzed by microbiological method and pharmacokinetic data had been analyzed by compartmentaland noncompartmental methods, results of mean ± standard deviation for half-life, volume of distributionand total body clearance for plasma samples were 0.67 ± 0.09 h., 0.169 ± 0.01 and 0.3 ± 0.02 L/hr/kg,respectively, the plasma protein binding ratio were 7.27 ± 0.22 %; while the half-life, Cmax and drugpenetration ratio for milk samples were 9.56 ± 3.13 h, 3.91 ± 0.99 ?g/ml and 0.86 ± 0.23 respectively. Inour conclusions; Depending on the approval state of Meropenem for veterinary therapy, we think that theachieved pharmacokinetic parameters of Meropenem in plasma and milk of ewes will candidate it to be oneof the preferred parentrally administered antibacterial agents to encounter the acute cases of mastitis thatought to be treated hastily.]]>
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