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All Journal Indian Journal of Forensic Medicine & Toxicology
Aishwarya R
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Public Health

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Natural Honey- as an Effective Adjunct in the Management of Radiation Induced Oral Mucositis Karthikeya Patil; M S Vishveshwara; Mahima V Guledgud; Aishwarya R; Prasannasrinivas Deshpande; Nagabhushana Doggalli
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14948

Abstract

Background - Malignancies are second most common cause of death in the world. Betel quid chewing,smoking, alcohol and low socioeconomic status contribute to its high prevalence. Its treatment protocolincludes surgery, radiotherapy, chemotherapy or a combination. Oral mucositis is an unavoidable mostfrequent, painful, distressing clinical side effect of radiotherapy.Methods – The study group consisted of 102 subjects diagnosed with carcinoma of head and neck andplanned for radiotherapy and had developed oral mucositis, among which 51 were in control group and 51in interventional group. The control group received 0.9% normal saline while interventional group receivednatural honey as topical application. Both the groups were evaluated by World Health Organization oralmucositis assessment scale and symptoms were assessed on verbal basis at baseline (I visit) and along withfour follow-up visits at an interval of 10 days, for total period of 40 days by 2 investigators. The studyduration was of 2 years.Conclusion- This study concludes that the topical application of honey can be used as an adjunct inalleviating the symptoms and in effective management of radiation mucositis as it is an easily available,simple, potent and inexpensive agent.
Bio Functional Evaluation of EGFR Expression as a Prognostic Indicator in Oral Squamous Cell Carcinoma and a Recommendation for Personalized Targeted Therapy with Anti EGFR Inhibitors Karthikeya Patil; Jayashree K; Mahima V Guledgud; Aishwarya R; Prasannasrinivas Deshpande; Nagabhushana Doggalli
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14951

Abstract

Background: Carcinoma is a complex, multifactorial and a devastating disease. Understanding the molecularchanges that leads to disease enables one to develop strategies to prevent, provide an early diagnosis andserve as targets for therapy. Epidermal Growth Factor Receptor (EGFR), a 170-kDa cell-surface proteinis a tyrosine kinase receptor from the ErbB family and is involved in many biological processes thataffect tumour development, growth progression, differentiation, inhibition of apoptosis and developmentof metastasis. Methods: Study included 54 cases of oral squamous cell carcinomas. EGFR expression byimmunohistochemistry has been studied, correlated with clinical parameters, known prognostic factors andpatient survival to note its significance.Conclusion: Head and Neck Squamous Cell Carcinoma (HNSCC) with or without regional lymph nodemetastases, are challenging to treat effectively. The prognosis for the patients with advanced stage of thedisease still remains poor. The correlation of EGFR overexpression with tumour size, grade, stage andsurvival suggests that EGFR expression can be considered as having prognostic significance and is apotential target for therapy with EGFR inhibitors in HNSCC. Further studies are required to assure theviability of EGFR levels in saliva as non-invasive prognostic marker and also as an indicator of recurrence.
Lipoid Proteinosis - A Rarity in An Adult Karthikeya Patil; Sanjay CJ; Mahima V Guledgud; Prasannasrinivas Deshpande; Aishwarya R; Nagabhushana Doggalli
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14952

Abstract

Background: Lipoid proteinosis is a rare genodermatosis with autosomal recessive inheritance. It isa multisystem disorder characterized by progressive deposition of hyaline material in the skin, mucousmembrane and different organs of the body. The disease is presented by dermatological, laryngeal,ophthalmological, and neurological manifestations. Involvement of oral mucosa may lead to xerostomia anddysphagia; involvement of larynx and eyes results in hoarseness of voice at early infancy and moniliformblepharosis. Extracutaneous involvement includes neurological manifestations like psychosis, partialcomplex seizures, anger, panic attacks, and progressive amnesia. Till date around 300 cases have beenreported in literature.Case Report: A 63 years old male patient reported with chief complaints of pain in the right and left cheekregion, difficulty in swallowing food and dryness of mouth.Conclusion: Lipoid Proteinosis requires multidisciplinary opinion and evaluation by dermatologists,ophthalmologists, otolaryngologists, neurologists and psychiatrist. Clinical features and histopathologicalevaluation aids in the confirmation of the disease. Lipoid proteinosis should be considered one among thedifferential diagnosis when patient reports with difficulty in mouth opening, enlarged tongue, difficult inchewing and swallowing.
Co-Authors Jayashree K Karthikeya Patil M S Vishveshwara Mahima V Guledgud Nagabhushana Doggalli Prasannasrinivas Deshpande Sanjay CJ