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Natural Honey- as an Effective Adjunct in the Management of Radiation Induced Oral Mucositis Karthikeya Patil; M S Vishveshwara; Mahima V Guledgud; Aishwarya R; Prasannasrinivas Deshpande; Nagabhushana Doggalli
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14948

Background - Malignancies are second most common cause of death in the world. Betel quid chewing,smoking, alcohol and low socioeconomic status contribute to its high prevalence. Its treatment protocolincludes surgery, radiotherapy, chemotherapy or a combination. Oral mucositis is an unavoidable mostfrequent, painful, distressing clinical side effect of radiotherapy.Methods – The study group consisted of 102 subjects diagnosed with carcinoma of head and neck andplanned for radiotherapy and had developed oral mucositis, among which 51 were in control group and 51in interventional group. The control group received 0.9% normal saline while interventional group receivednatural honey as topical application. Both the groups were evaluated by World Health Organization oralmucositis assessment scale and symptoms were assessed on verbal basis at baseline (I visit) and along withfour follow-up visits at an interval of 10 days, for total period of 40 days by 2 investigators. The studyduration was of 2 years.Conclusion- This study concludes that the topical application of honey can be used as an adjunct inalleviating the symptoms and in effective management of radiation mucositis as it is an easily available,simple, potent and inexpensive agent.

Cheilitis Granulomatosis - A Case Discussion Karthikeya Patil; Mahima V Guledgud; Prasannasrinivas Deshpande; Nagabhushana Doggalli; Mounika Prashanthi N
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14949

Introduction: Cheilitis granulomatosa is an idiopathic, cosmetically unpleasant, non-specific, painless,persistent granulomatous inflammation which affects one or both the lips. It is considered under the entityorofacial granulomatosis with very high rate of recurrence inspite of good treatment.Presentation of case: A 45 years old female patient reported with the chief complaint of swelling in theupper and lower lips for 2 years which had gradually increased in size since the onset. The swelling wasasymptomatic, firm in consistency. On histopathological examination the condition was diagnosed ascheilitis granulomatosaDiscussion: Cheilitis granulomatosa is considered as an entity of orofacial granulomatosis. It is asymptomatic,persistent swelling of the lips. The primary goal of management should be elimination of the predisposingfactor. Intralesional corticosteroids are considered as gold standard in the management of conditions. Insevere cases surgical management is helpful.

Bio Functional Evaluation of EGFR Expression as a Prognostic Indicator in Oral Squamous Cell Carcinoma and a Recommendation for Personalized Targeted Therapy with Anti EGFR Inhibitors Karthikeya Patil; Jayashree K; Mahima V Guledgud; Aishwarya R; Prasannasrinivas Deshpande; Nagabhushana Doggalli
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14951

Background: Carcinoma is a complex, multifactorial and a devastating disease. Understanding the molecularchanges that leads to disease enables one to develop strategies to prevent, provide an early diagnosis andserve as targets for therapy. Epidermal Growth Factor Receptor (EGFR), a 170-kDa cell-surface proteinis a tyrosine kinase receptor from the ErbB family and is involved in many biological processes thataffect tumour development, growth progression, differentiation, inhibition of apoptosis and developmentof metastasis. Methods: Study included 54 cases of oral squamous cell carcinomas. EGFR expression byimmunohistochemistry has been studied, correlated with clinical parameters, known prognostic factors andpatient survival to note its significance.Conclusion: Head and Neck Squamous Cell Carcinoma (HNSCC) with or without regional lymph nodemetastases, are challenging to treat effectively. The prognosis for the patients with advanced stage of thedisease still remains poor. The correlation of EGFR overexpression with tumour size, grade, stage andsurvival suggests that EGFR expression can be considered as having prognostic significance and is apotential target for therapy with EGFR inhibitors in HNSCC. Further studies are required to assure theviability of EGFR levels in saliva as non-invasive prognostic marker and also as an indicator of recurrence.

Lipoid Proteinosis - A Rarity in An Adult Karthikeya Patil; Sanjay CJ; Mahima V Guledgud; Prasannasrinivas Deshpande; Aishwarya R; Nagabhushana Doggalli
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14952

Background: Lipoid proteinosis is a rare genodermatosis with autosomal recessive inheritance. It isa multisystem disorder characterized by progressive deposition of hyaline material in the skin, mucousmembrane and different organs of the body. The disease is presented by dermatological, laryngeal,ophthalmological, and neurological manifestations. Involvement of oral mucosa may lead to xerostomia anddysphagia; involvement of larynx and eyes results in hoarseness of voice at early infancy and moniliformblepharosis. Extracutaneous involvement includes neurological manifestations like psychosis, partialcomplex seizures, anger, panic attacks, and progressive amnesia. Till date around 300 cases have beenreported in literature.Case Report: A 63 years old male patient reported with chief complaints of pain in the right and left cheekregion, difficulty in swallowing food and dryness of mouth.Conclusion: Lipoid Proteinosis requires multidisciplinary opinion and evaluation by dermatologists,ophthalmologists, otolaryngologists, neurologists and psychiatrist. Clinical features and histopathologicalevaluation aids in the confirmation of the disease. Lipoid proteinosis should be considered one among thedifferential diagnosis when patient reports with difficulty in mouth opening, enlarged tongue, difficult inchewing and swallowing.

Age Estimation Using the Radiographic Visibility of the Periodontal Ligament in Mandibular Third Molars in Mysore Population- A Retrospective Study Karthikeya Patil; Mahima VG; Poornima Chandran; Bharathi Penumatsa; Nagabhushana Doggalli; Sanjay CJ
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15316

Objectives: This study was conducted to assess the reliability of age estimation using the radiographic visibility of periodontal ligament surrounding the roots of completely erupted mandibular 3rd molar.Materials and methods:Visibility ofperiodontal ligament was assessed in completely erupted mandibular third molars, in a sample of 135 panoramic radiographs, of which 55 belonging to females and 80 to males, from a Mysore population aged 18to 32 years. A classification of four stages based on the visual phenomenon of disappearance of the periodontal ligament of fully mineralized third molars was used. For each stage, mean, standard deviation, minimal & maximal age were assessed.Results:The relationship between age and stage of periodontal ligament had a statistical significance for both sexes.In this population, stage 1 can be used for predictability of age above 19 years and stage 3 for predictability of age above 23 years. No significant correlation exists between periodontal ligament visibility and gender of the individual.Conclusion:Thistechnique is advocated for determining age above 19 years as it is a relatively simple and reliable method. Differences exist in different ethnicities demanding specific population standards.

Herbal therapy in Oral Submucous Fibrosis: A Short Review Sanjay C J; Shilpa Padar Shastry; Karthikeya Patil; Nagabhushana Doggalli; Naveen Kumar; Swathi Sharma
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15355

Oral submucous fibrosis (OSMF) is a potentially malignant disorder causing significant mortality andmorbidity. It is a chronic insidious disease, which progressively causes reduced mouth opening, stiffnessof oral mucosa and inability to eat. Treatment of this condition is difficult as various modalities have beenused, but with its own limitations and inefficiency. Reversing the fibrosis and improving the mouth openingremains the most challenging part of the management. In recent years, various studies have been conductedon usage of alternative modalities for the management of OSMF. These include several herbal products likealoevera, turmeric, spirulina, Oxitard, Tulsi, nigella sativa, turmeric with black pepper and many others.The objective of this article is to review various herbal agents that has been used in the treatment of OSMF.

Age Estimation of Adults Using Permanent Mandibular First Molars on Digital Panoramic Radiographs Meghana Maruthi; Karthikeya Patil; Mahima VG; Nagabhushana Doggalli; Sanjay CJ; Mahesh KP
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15868

Background: Morphometric analysis of teeth on radiographs for age estimation are considered to be simple, reliable and non-invasive. The aim of this study was to analyse the efficacy of tooth coronal index (TCI) to estimate age in Indian population and to assess the influence of diet and masticatory habit on TCI. The study comprised of 160 subjects in the age range of 21-71 years, categorized into groups based on chronological age, gender, diet and masticatory habit. Coronal Height (CH) and Coronal Pulp Cavity Height (CPCH) of permanent mandibular first molars was measured on digital panoramic radiographs using Planmeca Romexis software measurement tools. TCI was calculated using the formula: TCI= (CPCH ×100)/CH. Statistical analysis was performed, ANOVA and Pearson correlation was applied along with regression analysis to obtain an estimated age using TCI. Results: A negative correlation was obtained between the chronological age and TCI. Three-way ANOVA exhibited a significant difference in TCI within the age groups and dietary groups (p value = <0.05). There was no significant difference within the sexes, sides and masticatory groups. The most precise estimated age using the regression formula was in individuals between 31 – 40 years with an error of +/- 5 years in 55% of females, 65% of males. Conclusions: This study suggests that although TCI is a good predictor of age, it is most suitable to determine age of individuals between 31-40 years with the least error in estimation. This study also throws a light on the influence of diet on TCI.

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