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Budi Mulyaningsih Budi Mulyaningsih
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Immunology & microbiology Neuroscience

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Toxicity study of Zingiber officinale volatile oil as antifilariasis in mice and rats Budi Mulyaningsih Budi Mulyaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 02 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The volatile oil of Zingiber officinale has been reported effective to reduce microfilariae in Fells catus, L. According to the fact, there is chance that the volatile oil can be developed for treatment of filariasis in man. Before that idea can be realized some toxicity studies of Zingiber officinale should have to be done. Objective: This study was designed to know the potency of the acute and chronic toxicity in rodent. Methods: Acute toxicity study was perfomed in mice and rat as experimental animal and subchronic toxicity study was done only in mice. This study was done in standard methods.Results: The LD 50 value (mean ± SD) of Zingiber officinale volatile oil in mice was 8.051 ± 1.254 ml/Kg BW., while in rat the value was 12.99 ± 1.021 ml/Kg BW. Routine hematology analysis showed that no significant difference between the control and the experimental groups.Conclusion: The mechanism responsible in the death of the experimental animal in this toxicity study, seems to be the ability of the volatile oil to produce contraction of the smooth muscle especially in the airway system (trachea).Key words : microfilariae - filariasis - acute toxicity - Fells catus - chronic toxicity.
The effect of Zingiber officinale's active compounds against microfilariae Brugia malayi in Fells catus, L. Budi Mulyaningsih Budi Mulyaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 02 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Zingiber officinale, Rosa is a well known plant which can be used for the treatment of various diseases, and has been reported as an effective medicinal plant against Dirofilaria immitis in animal. The volatile oil and the pungent of Zingiber officinale, Rosa have been effectively used against larvae stage 3 (L3) B. malayi in vitro study.This study was designed to investigate the effect of the volatile oil and the pungent of Zingiber officinale, Rosc. against microfilariae B. malayi in Fells catus, L..Antifilarial activity of the pungent compound (isolate 1) and the volatile oil were assayed in vivo.The results showed that the volatile oil had the most quantity (rendement 0,5 %) and its activity against microfilariae B. malayi was higher than that of isolate 1, but lower than that of the dietylacarbamasine drug.Key words: microfilariae - volatile oil - the pungent of medicinal plant - B. malayi - Felis caws L
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